Habert R, Muczynski V, Grisin T, Moison D, Messiaen S, Frydman R, Benachi A, Delbes G, Lambrot R, Lehraiki A, N’Tumba-Byn T, Guerquin MJ, Levacher C, Rouiller-Fabre V, Livera G: Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors. Reproduction. 2014, 147: R119-129.
PubMed Central
CAS
PubMed
Google Scholar
Habert R, Picon R: Attempts for identification of a chorionic gonadotrophin-like bioactivity in the rat placenta which stimulates the testosterone secretion of the fetal testis in vitro. Biol Neonate. 1990, 58: 24-31.
CAS
PubMed
Google Scholar
Habert R, Lejeune H, Saez JM: Origin, differentiation and regulation of fetal and adult Leydig cells. Mol Cell Endocrinol. 2001, 179: 47-74.
CAS
PubMed
Google Scholar
Leridon H, Slama R: The impact of a decline in fecundity and of pregnancy postponement on final number of children and demand for assisted reproduction technology. Hum Reprod. 2008, 23: 1312-1319.
CAS
PubMed
Google Scholar
Main KM, Skakkebaek NE, Virtanen HE, Toppari J: Genital anomalies in boys and the environment. Best Pract Res Clin Endocrinol Metab. 2010, 24: 279-289.
PubMed
Google Scholar
Sharpe RM, Irvine DS: How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health?. BMJ. 2004, 328: 447-451.
PubMed Central
CAS
PubMed
Google Scholar
Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ, Jegou B, Jensen TK, Jouannet P, Keiding N, Leffers H, McLachlan JA, Meyer O, Muller J, Rajpert-De Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek NE: Male reproductive health and environmental xenoestrogens. Environ Health Perspect. 1996, 104 (Suppl 4): 741-803.
PubMed Central
CAS
PubMed
Google Scholar
Le Moal J, Rolland M, Goria S, Wagner V, De Crouy-Chanel P, Rigou A, De Mouzon J, Royere D: Semen quality trends in French regions are consistent with a global change in environmental exposure. Reproduction. 2014, 147: 567-574.
CAS
PubMed
Google Scholar
Skakkebaek NE, Rajpert-De Meyts E, Main KM: Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001, 16: 972-978.
CAS
PubMed
Google Scholar
Olesen IA, Sonne SB, Hoei-Hansen CE, Rajpert-De Meyts E, Skakkebaek NE: Environment, testicular dysgenesis and carcinoma in situ testis. Best Pract Res Clin Endocrinol Metab. 2007, 21: 462-478.
CAS
PubMed
Google Scholar
Delbes G, Levacher C, Habert R: Estrogen effects on fetal and neonatal testicular development. Reproduction. 2006, 132: 527-538.
CAS
PubMed
Google Scholar
Toppari J, Virtanen HE, Main KM, Skakkebaek NE: Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection. Birth Defects Res Part A Clin Mol Teratol. 2010, 88: 910-919.
CAS
PubMed
Google Scholar
Adamo C, Antignac J, Auger J, Balaguer P, Bourc’his D, Bujan L, Chevrier C, Cotinot C, Cravedi J, Laudet V, Livera G, Slama R: Reproduction et Environnement. 2011, Paris: INSERM edn
Google Scholar
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Lee DH, Myers JP, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT: Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. Reprod Toxicol. 2013, 38: 1-15.
PubMed Central
CAS
PubMed
Google Scholar
Giwercman A, Giwercman YL: Environmental factors and testicular function. Best Pract Res Clin Endocrinol Metab. 2011, 25: 391-402.
CAS
PubMed
Google Scholar
Habert R, Muczynski V, Lehraiki A, Lambrot R, Lecureuil C, Levacher C, Coffigny H, Pairault C, Moison D, Frydman R, Rouiller-Fabre V: Adverse effects of endocrine disruptors on the foetal testis development: focus on the phthalates. Folia Histochem Cyto. 2009, 47: S67-74.
CAS
Google Scholar
Sharpe RM, Skakkebaek NE: Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?. Lancet. 1993, 341: 1392-1395.
CAS
PubMed
Google Scholar
Juul A, Almstrup K, Andersson AM, Jensen TK, Jorgensen N, Main KM, Meyts ER, Toppari J, Skakkebaek NE: Possible fetal determinants of male infertility. Nat Rev Endocrinol. 2014
Google Scholar
Svechnikov K, Stukenborg JB, Savchuck I, Soder O: Similar causes of various reproductive disorders in early life. Asian J Androl. 2014, 16: 50-59.
PubMed Central
PubMed
Google Scholar
Sharpe RM, Skakkebaek NE: Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril. 2008, 89: e33-38.
PubMed
Google Scholar
Gray LE, Ostby J, Furr J, Price M, Veeramachaneni DN, Parks L: Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000, 58: 350-365.
CAS
PubMed
Google Scholar
Higuchi TT, Palmer JS, Gray LE, Veeramachaneni DN: Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. Toxicol Sci. 2003, 72: 301-313.
CAS
PubMed
Google Scholar
Mahood IK, Scott HM, Brown R, Hallmark N, Walker M, Sharpe RM: In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity. Environ Health Perspect. 2007, 115 (Suppl 1): 55-61.
PubMed Central
PubMed
Google Scholar
Mylchreest E, Foster PM: DBP exerts its antiandrogenic activity by indirectly interfering with androgen signaling pathways. Toxicol Appl Pharmacol. 2000, 168: 174-175.
CAS
Google Scholar
Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, Gray LE: The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci. 2000, 58: 339-349.
CAS
PubMed
Google Scholar
Wine RN, Li LH, Barnes LH, Gulati DK, Chapin RE: Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague–Dawley rats. Environ Health Perspect. 1997, 105: 102-107.
PubMed Central
CAS
PubMed
Google Scholar
Becker K, Seiwert M, Angerer J, Heger W, Koch HM, Nagorka R, Rosskamp E, Schluter C, Seifert B, Ullrich D: DEHP metabolites in urine of children and DEHP in house dust. Int J Hyg Environ Health. 2004, 207: 409-417.
CAS
PubMed
Google Scholar
Koch HM, Becker K, Wittassek M, Seiwert M, Angerer J, Kolossa-Gehring M: Di-n-butylphthalate and butylbenzylphthalate - urinary metabolite levels and estimated daily intakes: pilot study for the German Environmental Survey on children. J Expo Sci Environ Epidemiol. 2007, 17: 378-387.
CAS
PubMed
Google Scholar
Wormuth M, Scheringer M, Vollenweider M, Hungerbuhler K: What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal. 2006, 26: 803-824.
PubMed
Google Scholar
Latini G: Monitoring phthalate exposure in humans. Clin Chim Acta. 2005, 361: 20-29.
CAS
PubMed
Google Scholar
Saravanabhavan G, Murray J: Human biological monitoring of diisononyl phthalate and diisodecyl phthalate: a review. J Environ Public Health. 2012, 2012: 810501-
PubMed Central
PubMed
Google Scholar
Koch HM, Bolt HM, Preuss R, Angerer J: New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Arch Toxicol. 2005, 79: 367-376.
CAS
PubMed
Google Scholar
Koch HM, Drexler H, Angerer J: An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int J Hyg Environ Health. 2003, 206: 77-83.
CAS
PubMed
Google Scholar
Marsee K, Woodruff TJ, Axelrad DA, Calafat AM, Swan SH: Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. Environ Health Perspect. 2006, 114: 805-809.
PubMed Central
CAS
PubMed
Google Scholar
Latini G, De Felice C, Presta G, Del Vecchio A, Paris I, Ruggieri F, Mazzeo P: In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy. Environ Health Perspect. 2003, 111: 1783-1785.
PubMed Central
CAS
PubMed
Google Scholar
Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP, Brock JW, Needham LL, Calafat AM: Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. Environ Health Perspect. 2004, 112: 331-338.
PubMed Central
CAS
PubMed
Google Scholar
Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL, Study for Future Families Research T: Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 2005, 113: 1056-1061.
PubMed Central
CAS
PubMed
Google Scholar
Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, Schmidt IM, Suomi AM, Virtanen HE, Petersen DV, Andersson AM, Toppari J, Skakkebaek NE: Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006, 114: 270-276.
PubMed Central
CAS
PubMed
Google Scholar
Hogberg J, Hanberg A, Berglund M, Skerfving S, Remberger M, Calafat AM, Filipsson AF, Jansson B, Johansson N, Appelgren M, Hakansson H: Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations. Environ Health Perspect. 2008, 116: 334-339.
PubMed Central
PubMed
Google Scholar
Huang PC, Kuo PL, Chou YY, Lin SJ, Lee CC: Association between prenatal exposure to phthalates and the health of newborns. Environ Int. 2009, 35: 14-20.
PubMed
Google Scholar
Suzuki Y, Yoshinaga J, Mizumoto Y, Serizawa S, Shiraishi H: Foetal exposure to phthalate esters and anogenital distance in male newborns. Int J Androl. 2012, 35: 236-244.
CAS
PubMed
Google Scholar
Bustamante-Montes LP, Hernandez-Valero MA, Flores-Pimentel D, Garcia-Fabila M, Amaya-Chavez A, Barr DB, Borja-Aburto VH: Prenatal exposure to phthalates is associated with decreased anogenital distance and penile size in male newborns. J Dev Orig Health Dis. 2013, 4: 300-306.
CAS
PubMed
Google Scholar
Scott HM, Mason JI, Sharpe RM: Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr Rev. 2009, 30: 883-925.
CAS
PubMed
Google Scholar
O’Shaughnessy PJ, Fowler PA: Endocrinology of the mammalian fetal testis. Reproduction. 2011, 141: 37-46.
PubMed
Google Scholar
Svechnikov K, Landreh L, Weisser J, Izzo G, Colon E, Svechnikova I, Soder O: Origin, development and regulation of human Leydig cells. Horm Res Paediatr. 2010, 73: 93-101.
CAS
PubMed
Google Scholar
Tapanainen J, Kellokumpu-Lehtinen P, Pelliniemi L, Huhtaniemi I: Age-related changes in endogenous steroids of human fetal testis during early and midpregnancy. J Clin Endocrinol Metab. 1981, 52: 98-102.
CAS
PubMed
Google Scholar
Lambrot R, Livera G, Coffigny H, Pairault C, Frydman R, Habert R, Rouiller-Fabre V: A new method for toxicity assays on human and mouse fetal testis. Biochimie. 2006, 88: 1831-1835.
CAS
PubMed
Google Scholar
Habert R, Picon R: Testosterone, dihydrotestosterone and estradiol-17 beta levels in maternal and fetal plasma and in fetal testes in the rat. J Steroid Biochem. 1984, 21: 193-198.
CAS
PubMed
Google Scholar
Tapanainen J, Kuopio T, Pelliniemi LJ, Huhtaniemi I: Rat testicular endogenous steroids and number of Leydig cells between the fetal period and sexual maturity. Biol Reprod. 1984, 31: 1027-1035.
CAS
PubMed
Google Scholar
Kerr JB, Knell CM: The fate of fetal Leydig cells during the development of the fetal and postnatal rat testis. Development. 1988, 103: 535-544.
CAS
PubMed
Google Scholar
Habert R, Brignaschi P: Developmental changes in in vitro testosterone production by dispersed Leydig cells during fetal life in rats. Arch Androl. 1991, 27: 65-71.
CAS
PubMed
Google Scholar
Huhtaniemi I: Endocrine function and regulation of the fetal and neonatal testis. Int J Dev Biol. 1989, 33: 117-123.
CAS
PubMed
Google Scholar
Habert R, Veniard B, Brignaschi P, Gangnerau MN, Picon R: Absence of development of late steroidogenic lesions in rat testis during the end of fetal life. Arch Androl. 1989, 22: 41-48.
CAS
PubMed
Google Scholar
Habert R, Picon R: Control of testicular steroidogenesis in foetal rat: effect of decapitation on testosterone and plasma luteinizing hormone-like activity. Acta Endocrinol (Copenh). 1982, 99: 466-473.
CAS
Google Scholar
Migrenne S, Pairault C, Racine C, Livera G, Geloso A, Habert R: Luteinizing hormone-dependent activity and luteinizing hormone-independent differentiation of rat fetal Leydig cells. Mol Cell Endocrinol. 2001, 172: 193-202.
CAS
PubMed
Google Scholar
Habert R: In vivo acute testicular testosterone response to injection of luteinizing hormone in the rat fetus. Acta Endocrinol (Copenh). 1993, 128: 268-273.
CAS
Google Scholar
Borday C, Merlet J, Racine C, Habert R: Expression and localization of aromatase during fetal mouse testis development. Basic Clin Androl. 2013, 23: 13-
Google Scholar
Migrenne S, Moreau E, Pakarinen P, Dierich A, Merlet J, Habert R, Racine C: Mouse testis development and function are differently regulated by follicle-stimulating hormone receptors signaling during fetal and prepubertal life. PLoS ONE. 2012, 7: e53257-
PubMed Central
CAS
PubMed
Google Scholar
Svechnikov K, Izzo G, Landreh L, Weisser J, Soder O: Endocrine disruptors and Leydig cell function. J Biomed Biotechnol. 2010, 2010: Article ID684504-
Google Scholar
Martinez-Arguelles DB, Campioli E, Culty M, Zirkin BR, Papadopoulos V: Fetal origin of endocrine dysfunction in the adult: the phthalate model. J Steroid Biochem Mol Biol. 2013, 137: 5-17.
CAS
PubMed
Google Scholar
Barlow NJ, Foster PM: Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to Di(n-butyl) phthalate. Toxicol Pathol. 2003, 31: 397-410.
PubMed
Google Scholar
Mahood IK, Hallmark N, McKinnell C, Walker M, Fisher JS, Sharpe RM: Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis. Endocrinology. 2005, 146: 613-623.
CAS
PubMed
Google Scholar
Hallmark N, Walker M, McKinnell C, Mahood IK, Scott H, Bayne R, Coutts S, Anderson RA, Greig I, Morris K, Sharpe RM: Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. Environ Health Perspect. 2007, 115: 390-396.
PubMed Central
CAS
PubMed
Google Scholar
Fisher JS, Macpherson S, Marchetti N, Sharpe RM: Human 'testicular dysgenesis syndrome’: a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod. 2003, 18: 1383-1394.
CAS
PubMed
Google Scholar
Lehmann KP, Phillips S, Sar M, Foster PM, Gaido KW: Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci. 2004, 81: 60-68.
CAS
PubMed
Google Scholar
Howdeshell KL, Rider CV, Wilson VS, Gray LE: Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats. Environ Res. 2008, 108: 168-176.
CAS
PubMed
Google Scholar
Saillenfait AM, Sabate JP, Robert A, Rouiller-Fabre V, Roudot AC, Moison D, Denis F: Dose-dependent alterations in gene expression and testosterone production in fetal rat testis after exposure to di-n-hexyl phthalate. J Appl Toxicol. 2013, 33: 1027-1035.
CAS
PubMed
Google Scholar
Thompson CJ, Ross SM, Gaido KW: Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Endocrinology. 2004, 145: 1227-1237.
CAS
PubMed
Google Scholar
Borch J, Metzdorff SB, Vinggaard AM, Brokken L, Dalgaard M: Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology. 2006, 223: 144-155.
CAS
PubMed
Google Scholar
Culty M, Thuillier R, Li W, Wang Y, Martinez-Arguelles DB, Benjamin CG, Triantafilou KM, Zirkin BR, Papadopoulos V: In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat. Biol Reprod. 2008, 78: 1018-1028.
CAS
PubMed
Google Scholar
van den Driesche S, Walker M, McKinnell C, Scott HM, Eddie SL, Mitchell RT, Seckl JR, Drake AJ, Smith LB, Anderson RA, Sharpe RM: Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents. PLoS ONE. 2012, 7: e37064-
PubMed Central
CAS
PubMed
Google Scholar
Anand-Ivell R, Ivell R: Insulin-like factor 3 as a monitor of endocrine disruption. Reproduction. 2014, 147: R87-95.
CAS
PubMed
Google Scholar
Wilson VS, Lambright C, Furr J, Ostby J, Wood C, Held G, Gray LE: Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. Toxicol Lett. 2004, 146: 207-215.
CAS
PubMed
Google Scholar
McKinnell C, Sharpe RM, Mahood K, Hallmark N, Scott H, Ivell R, Staub C, Jegou B, Haag F, Koch-Nolte F, Hartung S: Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. Endocrinology. 2005, 146: 4536-4544.
CAS
PubMed
Google Scholar
Howdeshell KL, Wilson VS, Furr J, Lambright CR, Rider CV, Blystone CR, Hotchkiss AK, Gray LE: A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague–Dawley rat in a cumulative, dose-additive manner. Toxicol Sci. 2008, 105: 153-165.
CAS
PubMed
Google Scholar
Jost A, Vigier B, Prepin J, Perchellet JP: Studies on sex differentiation in mammals. Recent Prog Horm Res. 1973, 29: 1-41.
CAS
PubMed
Google Scholar
Jost A: Hormonal factors in the sex differentiation of the mammalian foetus. Philos T Roy Soc B. 1970, 259: 119-130.
CAS
Google Scholar
Welsh M, Saunders PT, Fisken M, Scott HM, Hutchison GR, Smith LB, Sharpe RM: Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest. 2008, 118: 1479-1490.
PubMed Central
CAS
PubMed
Google Scholar
Macleod DJ, Sharpe RM, Welsh M, Fisken M, Scott HM, Hutchison GR, Drake AJ, van den Driesche S: Androgen action in the masculinization programming window and development of male reproductive organs. Int J Androl. 2010, 33: 279-287.
CAS
PubMed
Google Scholar
Gray LE, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, Veeramachaneni DN, Wilson V, Price M, Hotchkiss A, Orlando E, Guillette L: Effects of environmental antiandrogens on reproductive development in experimental animals. Hum Reprod Update. 2001, 7: 248-264.
CAS
PubMed
Google Scholar
Foster PM, Mylchreest E, Gaido KW, Sar M: Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update. 2001, 7: 231-235.
CAS
PubMed
Google Scholar
Fisher JS: Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction. 2004, 127: 305-315.
CAS
PubMed
Google Scholar
Foster PM: Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl. 2006, 29: 140-147. discussion 181–145
CAS
PubMed
Google Scholar
Gray LE, Wilson VS, Stoker T, Lambright C, Furr J, Noriega N, Howdeshell K, Ankley GT, Guillette L: Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Int J Androl. 2006, 29: 96-104. discussion 105–108
CAS
PubMed
Google Scholar
Toppari J, Virtanen H, Skakkebaek NE, Main KM: Environmental effects on hormonal regulation of testicular descent. J Steroid Biochem Mol Biol. 2006, 102: 184-186.
CAS
PubMed
Google Scholar
Ge RS, Chen GR, Tanrikut C, Hardy MP: Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations. Reprod Toxicol. 2007, 23: 366-373.
CAS
PubMed
Google Scholar
Hu GX, Lian QQ, Ge RS, Hardy DO, Li XK: Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence. Trends Endocrinol Metab. 2009, 20: 139-145.
PubMed Central
CAS
PubMed
Google Scholar
Struve MF, Gaido KW, Hensley JB, Lehmann KP, Ross SM, Sochaski MA, Willson GA, Dorman DC: Reproductive toxicity and pharmacokinetics of di-n-butyl phthalate (DBP) following dietary exposure of pregnant rats. Birth Defects Res B Dev Reprod Toxicol. 2009, 86: 345-354.
CAS
PubMed
Google Scholar
Lee KY, Shibutani M, Takagi H, Kato N, Takigami S, Uneyama C, Hirose M: Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation. Toxicology. 2004, 203: 221-238.
CAS
PubMed
Google Scholar
Clewell RA, Thomas A, Willson G, Creasy DM, Andersen ME: A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development. Reprod Toxicol. 2013, 35: 70-80.
CAS
PubMed
Google Scholar
Gray LE, Barlow NJ, Howdeshell KL, Ostby JS, Furr JR, Gray CL: Transgenerational effects of Di (2-ethylhexyl) phthalate in the male CRL:CD(SD) rat: added value of assessing multiple offspring per litter. Toxicol Sci. 2009, 110: 411-425.
PubMed Central
CAS
PubMed
Google Scholar
Christiansen S, Boberg J, Axelstad M, Dalgaard M, Vinggaard AM, Metzdorff SB, Hass U: Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats. Reprod Toxicol. 2010, 30: 313-321.
CAS
PubMed
Google Scholar
Liu K, Lehmann KP, Sar M, Young SS, Gaido KW: Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis. Biol Reprod. 2005, 73: 180-192.
CAS
PubMed
Google Scholar
Witorsch RJ, Thomas JA: Personal care products and endocrine disruption: a critical review of the literature. Crit Rev Toxicol. 2010, 40 (Suppl 3): 1-30.
CAS
PubMed
Google Scholar
Johnson KJ, Heger NE, Boekelheide K: Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent. Toxicol Sci. 2012, 129: 235-248.
PubMed Central
CAS
PubMed
Google Scholar
Veeramachaneni DN, Klinefelter GR: Phthalate-induced pathology in the foetal testis involves more than decreased testosterone production. Reproduction. 2014, 147: 435-442.
CAS
PubMed
Google Scholar
Swan SH: Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res. 2008, 108: 177-184.
PubMed Central
CAS
PubMed
Google Scholar
Choi H, Kim J, Im Y, Lee S, Kim Y: The association between some endocrine disruptors and hypospadias in biological samples. J Environ Sci Health A Tox. 2012, 47: 2173-2179.
CAS
Google Scholar
Ormond G, Nieuwenhuijsen MJ, Nelson P, Toledano MB, Iszatt N, Geneletti S, Elliott P: Endocrine disruptors in the workplace, hair spray, folate supplementation, and risk of hypospadias: case–control study. Environ Health Perspect. 2009, 117: 303-307.
PubMed Central
PubMed
Google Scholar
Teitelbaum SL, Britton JA, Calafat AM, Ye X, Silva MJ, Reidy JA, Galvez MP, Brenner BL, Wolff MS: Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res. 2008, 106: 257-269.
CAS
PubMed
Google Scholar
Sathyanarayana S, Barrett E, Butts S, Wang C, Swan SH: Phthalate exposure and reproductive hormone concentrations in pregnancy. Reproduction. 2014, 147: 401-409.
PubMed Central
CAS
PubMed
Google Scholar
N’Tumba-Byn T, Moison D, Lacroix M, Lecureuil C, Lesage L, Prud’homme SM, Pozzi-Gaudin S, Frydman R, Benachi A, Livera G, Rouiller-Fabre V, Habert R: Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal leydig cell function. PLoS ONE. 2012, 7: e51579-
PubMed Central
PubMed
Google Scholar
Habert R, Devif I, Gangnerau MN, Lecerf L: Ontogenesis of the in vitro response of rat testis to gonadotropin-releasing hormone. Mol Cell Endocrinol. 1991, 82: 199-206.
CAS
PubMed
Google Scholar
Lambrot R, Coffigny H, Pairault C, Donnadieu AC, Frydman R, Habert R, Rouiller-Fabre V: Use of organ culture to study the human fetal testis development: effect of retinoic acid. J Clin Endocrinol Metab. 2006, 91: 2696-2703.
CAS
PubMed
Google Scholar
Lecerf L, Rouiller-Fabre V, Levacher C, Gautier C, Saez JM, Habert R: Stimulatory effect of follicle-stimulating hormone on basal and luteinizing hormone-stimulated testosterone secretions by the fetal rat testis in vitro. Endocrinology. 1993, 133: 2313-2318.
CAS
PubMed
Google Scholar
Olaso R, Pairault C, Boulogne B, Durand P, Habert R: Transforming growth factor beta1 and beta2 reduce the number of gonocytes by increasing apoptosis. Endocrinology. 1998, 139: 733-740.
CAS
PubMed
Google Scholar
Livera G, Rouiller-Fabre V, Durand P, Habert R: Multiple effects of retinoids on the development of Sertoli, germ, and Leydig cells of fetal and neonatal rat testis in culture. Biol Reprod. 2000, 62: 1303-1314.
CAS
PubMed
Google Scholar
Livera G, Delbes G, Pairault C, Rouiller-Fabre V, Habert R: Organotypic culture, a powerful model for studying rat and mouse fetal testis development. Cell Tissue Res. 2006, 324: 507-521.
PubMed
Google Scholar
Lambrot R, Muczynski V, Lecureuil C, Angenard G, Coffigny H, Pairault C, Moison D, Frydman R, Habert R, Rouiller-Fabre V: Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production. Environ Health Perspect. 2009, 117: 32-37.
PubMed Central
CAS
PubMed
Google Scholar
Muczynski V, Cravedi JP, Lehraiki A, Levacher C, Moison D, Lecureuil C, Messiaen S, Perdu E, Frydman R, Habert R, Rouiller-Fabre V: Effect of mono-(2-ethylhexyl) phthalate on human and mouse fetal testis: In vitro and in vivo approaches. Toxicol Appl Pharmacol. 2012, 261: 97-104.
CAS
PubMed
Google Scholar
Muczynski V, Lecureuil C, Messiaen S, Guerquin MJ, N’Tumba-Byn T, Moison D, Hodroj W, Benjelloun H, Baijer J, Livera G, Frydman R, Benachi A, Habert R, Rouiller-Fabre V: Cellular and molecular effect of MEHP Involving LXRalpha in human fetal testis and ovary. PLoS ONE. 2012, 7: e48266-
PubMed Central
CAS
PubMed
Google Scholar
Delbes G, Duquenne C, Szenker J, Taccoen J, Habert R, Levacher C: Developmental changes in testicular sensitivity to estrogens throughout fetal and neonatal life. Toxicol Sci. 2007, 99: 234-243.
CAS
PubMed
Google Scholar
Mitchell RT, Saunders PT, Childs AJ, Cassidy-Kojima C, Anderson RA, Wallace WH, Kelnar CJ, Sharpe RM: Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation. Hum Reprod. 2010, 25: 2405-2414.
PubMed Central
CAS
PubMed
Google Scholar
Mitchell RT, Childs AJ, Anderson RA, van den Driesche S, Saunders PT, McKinnell C, Wallace WH, Kelnar CJ, Sharpe RM: Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate. J Clin Endocrinol Metab. 2012, 97: E341-348.
CAS
PubMed
Google Scholar
Heger NE, Hall SJ, Sandrof MA, McDonnell EV, Hensley JB, McDowell EN, Martin KA, Gaido KW, Johnson KJ, Boekelheide K: Human fetal testis xenografts are resistant to phthalate-induced endocrine disruption. Environ Health Perspect. 2012, 120: 1137-1143.
PubMed Central
CAS
PubMed
Google Scholar
Spade DJ, Hall SJ, Saffarini CM, Huse SM, McDonnell EV, Boekelheide K: Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay. Toxicol Sci. 2014, 138: 148-160.
PubMed Central
CAS
PubMed
Google Scholar
Gaido KW, Hensley JB, Liu D, Wallace DG, Borghoff S, Johnson KJ, Hall SJ, Boekelheide K: Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone. Toxicol Sci. 2007, 97: 491-503.
CAS
PubMed
Google Scholar
Liu X, He DW, Zhang DY, Lin T, Wei GH: Di(2-ethylhexyl) phthalate (DEHP) increases transforming growth factor-beta1 expression in fetal mouse genital tubercles. J Toxic Environ Health A. 2008, 71: 1289-1294.
CAS
Google Scholar
Do RP, Stahlhut RW, Ponzi D, Vom Saal FS, Taylor JA: Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod Toxicol. 2012, 34: 614-621.
PubMed Central
CAS
PubMed
Google Scholar
Song XF, Wei GH, Liu X, Zhang DY, Chen X, Deng YJ: Effects of diethylhexyl phthalate (DEHP) on INSL3 mRNA expression by Leydig cells derived from mouse embryos and in newborn mice. J INT MED RES. 2008, 36: 512-521.
CAS
PubMed
Google Scholar
Lehraiki A, Racine C, Krust A, Habert R, Levacher C: Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism. Toxicol Sci. 2009, 111: 372-382.
PubMed Central
CAS
PubMed
Google Scholar
McKinnell C, Mitchell RT, Walker M, Morris K, Kelnar CJ, Wallace WH, Sharpe RM: Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset. Hum Reprod. 2009, 24: 2244-2254.
PubMed Central
CAS
PubMed
Google Scholar
Li LH, Donald JM, Golub MS: Review on testicular development, structure, function, and regulation in common marmoset. Birth Defects Res B Dev Reprod Toxicol. 2005, 74: 450-469.
CAS
PubMed
Google Scholar
Kleymenova E, Swanson C, Boekelheide K, Gaido KW: Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat Sertoli cells and disrupts Sertoli cell-gonocyte contact. Biol Reprod. 2005, 73: 482-490.
CAS
PubMed
Google Scholar
Mitchell RT, Sharpe RM, Anderson RA, McKinnell C, Macpherson S, Smith LB, Wallace WH, Kelnar CJ, van den Driesche S: Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts. PLoS ONE. 2013, 8: e61726-
PubMed Central
CAS
PubMed
Google Scholar
Delbes G, Levacher C, Duquenne C, Racine C, Pakarinen P, Habert R: Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha. Endocrinology. 2005, 146: 2454-2461.
CAS
PubMed
Google Scholar
Gaskell TL, Robinson LL, Groome NP, Anderson RA, Saunders PT: Differential expression of two estrogen receptor beta isoforms in the human fetal testis during the second trimester of pregnancy. J Clin Endocrinol Metab. 2003, 88: 424-432.
CAS
PubMed
Google Scholar
Mylchreest E, Sar M, Wallace DG, Foster PM: Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod Toxicol. 2002, 16: 19-28.
CAS
PubMed
Google Scholar
Ferrara D, Hallmark N, Scott H, Brown R, McKinnell C, Mahood IK, Sharpe RM: Acute and long-term effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation. Endocrinology. 2006, 147: 5352-5362.
CAS
PubMed
Google Scholar
Saffarini CM, Heger NE, Yamasaki H, Liu T, Hall SJ, Boekelheide K: Induction and persistence of abnormal testicular germ cells following gestational exposure to di-(n-butyl) phthalate in p53-null mice. J Androl. 2012, 33: 505-513.
PubMed Central
CAS
PubMed
Google Scholar
Li H, Kim KH: Effects of mono-(2-ethylhexyl) phthalate on fetal and neonatal rat testis organ cultures. Biol Reprod. 2003, 69: 1964-1972.
CAS
PubMed
Google Scholar
Hutchison GR, Scott HM, Walker M, McKinnell C, Ferrara D, Mahood IK, Sharpe RM: Sertoli cell development and function in an animal model of testicular dysgenesis syndrome. Biol Reprod. 2008, 78: 352-360.
CAS
PubMed
Google Scholar
Mazaud-Guittot S: Dissecting the phthalate-induced Sertoli cell injury: the fragile balance of proteases and their inhibitors. Biol Reprod. 2011, 85: 1091-1093.
CAS
PubMed
Google Scholar