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  1. Severe or complete asthenozoospermia is a rare entity that can lead to male infertility. In this study, we explored whether different extents of severe or complete asthenozoospermia could affect intracytoplasm...

    Authors: Tong Chen, Demin Fan, Xianlong Wang, Changlin Mao, Yaru Chu, Haobo Zhang, Wen Liu, Sentai Ding, Qingyong Liu, Mingzhen Yuan and Jiaju Lu
    Citation: Basic and Clinical Andrology 2022 32:6
    Content type: Research article Published on:

  2. Erectile dysfunction (ED) often occurs due to cavernous nerve injury (CNI) after colorectal surgery. Cell-based therapies have great potential for the treatment of CNI-related ED; however, it needs to be optim...

    Authors: Zhenbin Zhang, Pan Nie, Wende Yang, Xiaolei Ma, Zehong Chen and Hongbo Wei
    Citation: Basic and Clinical Andrology 2022 32:5
    Content type: Research article Published on:

  3. Penile schwannoma is a rare tumor. They commonly present as an asymptomatic, painless and slow growing mass. Other presentations include sexual dysfunction, most commonly dyspareunia, followed by erectile dysf...

    Authors: Chan Ming Tow, Jonathan Tang, Chan Ming Chun and Joe Lee King Chien
    Citation: Basic and Clinical Andrology 2022 32:4
    Content type: Case report Published on:

  4. A very small number of studies have indicated that azoospermia or negative testicular sperm extraction (TESE) outcomes are linked to depression or erectile dysfunction. However, the data are often weak, confli...

    Authors: Marion BENDAYAN, Emine SAIS, Laura ALTER, Khadija FATHALLAH, Monique JAOUL, Pierre Olivier BOSSET, Geoffroy ROBIN and Florence BOITRELLE
    Citation: Basic and Clinical Andrology 2022 32:3
    Content type: Research article Published on:

  5. Spermatogenesis in mammals is a heat-sensitive developmental pathway incompatible with the typical mammalian body temperature of 37 °C. It is thought that this is the reason why the testicles of most mammalian...

    Authors: Faruk Hadziselimovic
    Citation: Basic and Clinical Andrology 2022 32:2
    Content type: Review article Published on:

  6. The ischiocavernosus muscle (ICM) encompasses a pair of short pinnate muscles attached to the pelvic ring. The ICM begins at the ischial tuberosity and ends at the crus of the penis while covering the surface ...

    Authors: Chengren Gou, Tong Liu, Zongping Chen, Zidong Zhou, Tao Song, Kaiyi Mao, Congcong Chen and Bo Chen
    Citation: Basic and Clinical Andrology 2022 32:1
    Content type: Research article Published on:

  7. Hormones like testosterone play a crucial role in performance enhancement and muscle growth. Therefore, various attempts to increase testosterone release and testosterone concentration have been made, especial...

    Authors: Eduard Isenmann, Moritz Schumann, Hannah L. Notbohm, Ulrich Flenker and Philipp Zimmer
    Citation: Basic and Clinical Andrology 2021 31:32
    Content type: Short report Published on:

  9. Non-obstructive azoospermia (NOA) with history of cryptorchidism and idiopathic NOA are the most common forms of NOA without genetic aetiology. Of all patients with one of these two types of NOA, only a few wi...

    Authors: Jacques Singh Sangwan, Claire Petit, Romane Sainte Rose, Cynthia Frapsauce, Laura Dijols, Jean Marc Rigot and Fabrice Guérif
    Citation: Basic and Clinical Andrology 2021 31:30
    Content type: Research article Published on:

  10. Recent studies suggest that serum vitamin D may be associated with semen parameters. In the present cross-sectional study, we attempted to investigate the association between serum vitamin D levels and semen p...

    Authors: Hossein Hajianfar, Elham Karimi, Negar Mollaghasemi, Sheyda Rezaei and Arman Arab
    Citation: Basic and Clinical Andrology 2021 31:29
    Content type: Research article Published on:

  11. Several recent journal articles report that d-chiro-inositol (DCI), primarily known as insulin second messenger, influences steroidogenesis. In particular, new evidence is arising on DCI ability to regulate aroma...

    Authors: Maurizio Nordio, Philip Kumanov, Alfonsina Chiefari and Giulia Puliani
    Citation: Basic and Clinical Andrology 2021 31:28
    Content type: Research article Published on:

  12. Although chromosome rearrangements are responsible for spermatogenesis failure, their impact depends greatly on the chromosomes involved. At present, karyotyping and Y chromosome microdeletion screening are th...

    Authors: Farah Ghieh, Anne-Laure Barbotin, Julie Prasivoravong, Sophie Ferlicot, Béatrice Mandon-Pepin, Joanne Fortemps, Henri-Jean Garchon, Valérie Serazin, Clara Leroy, François Marcelli and François Vialard
    Citation: Basic and Clinical Andrology 2021 31:27
    Content type: Case report Published on:

  13. Although widely used, slow freezing considerably modifies the functions of human spermatozoa. Cryopreservation induces nuclear sperm alterations and cryo-capacitation, reducing the chances of pregnancy. Hypota...

    Authors: Hanae Pons-Rejraji, Solène Vorilhon, Asmaa Difrane, Sandra Dollet, Céline Bourgne, Marc Berger, Laure Chaput, Bruno Pereira, Cyril Bouche, Joël R. Drevet and Florence Brugnon
    Citation: Basic and Clinical Andrology 2021 31:26
    Content type: Research article Published on:

  14. The use of flow cytometry (FC) to evaluate sperm DNA fragmentation via deoxynucleotidyl transferase terminal fluorescein dUTP nick-end labeling (TUNEL) has shown inconsistencies compared with conventional fluo...

    Authors: Niloofar Sadeghi, Marziyeh Tavalaee, Abbas Kiani-Esfahani, Aron Moazamian, Parviz Gharagozloo, Robert J. Aitken, Joël R. Drevet and Mohammad Hossein Nasr-Esfahani
    Citation: Basic and Clinical Andrology 2021 31:23
    Content type: Research article Published on:

  15. Extracellular Vesicles (EVs) are membrane-limited particles containing proteins, lipids, metabolites and nucleic acids that are secreted by healthy and cancerous cells. These vesicles are very heterogeneous in...

    Authors: Anne-Sophie Neyroud, Régina Chiechio, Marina Yefimova, Maria Josè Lo Faro, Nathalie Dejucq-Rainsford, Sylvie Jaillard, Pascale Even-Hernandez, Valérie Marchi and Célia Ravel
    Citation: Basic and Clinical Andrology 2021 31:25
    Content type: Review article Published on:

  16. A direct association between metabolic syndrome (MetS) and sperm production/function has been proposed. In this cross-sectional study, we aimed to determine the impact of MetS on sperm survival. Men from infer...

    Authors: Minh Tam Le, Hiep Tuyet Thi Nguyen, Hong Nhan Thi Dang, Thai Thanh Thi Nguyen, Trung Van Nguyen and Quoc Huy Vu Nguyen
    Citation: Basic and Clinical Andrology 2021 31:22
    Content type: Research article Published on:

  17. Sperm cryopreservation, an effective method for preserving male fertility, is very advantageous for men suffering from cancer. Unfortunately, as both physicians and cancer patients are unaware of the possibili...

    Authors: Xiao Liu, Bo Liu, Shasha Liu, Yang Xian, Wenrui Zhao, Bin Zhou, Xiao Xiao, Li Wang, Xiaofang Zhu, Bizhen Shu, Min Jiang and Fuping Li
    Citation: Basic and Clinical Andrology 2021 31:24
    Content type: Research article Published on:

  18. Bromodomain-containing protein 7 (BRD7), a member of the bromodomain-containing protein family, plays important roles in chromatin modification and transcriptional regulation. A recent model of Brd7-knockout mice...

    Authors: Tianrong He, Mohan Liu, Dachang Tao, Xiangyou Leng, Zhaokun Wang, Shengyu Xie, Yangwei Zhang, Xinyue Zhang, Xiaolan Tan, Yunqiang Liu and Yuan Yang
    Citation: Basic and Clinical Andrology 2021 31:19
    Content type: Research article Published on:

  19. Whereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (W...

    Authors: Farah Ghieh, Anne-Laure Barbotin, Clara Leroy, François Marcelli, Nelly Swierkowsky-Blanchard, Valérie Serazin, Béatrice Mandon-Pepin and François Vialard
    Citation: Basic and Clinical Andrology 2021 31:21
    Content type: Commentary Published on:

  20. Asthenozoospermia is a usual male infertility factor, characterized by decreased semen quality. It has been revealed that antioxidants improve sperm function, enhance endogenous antioxidant activities, and pro...

    Authors: Reza Asadpour, Morteza Taravat, Maryam Rahbar, Mohammadrasoul Khoshniyat and Gholamreza Hamidian
    Citation: Basic and Clinical Andrology 2021 31:20
    Content type: Research article Published on:

  21. During the last decades, the abuse of anabolic androgenic steroids (AASs) has become popular among professional and recreational athletes. The abuse of AASs leads to decreased levels of sex hormones, but the a...

    Authors: Jasmina Sretenovic, Jovana Joksimovic Jovic, Ivan Srejovic, Vladimir Zivkovic, Katarina Mihajlovic, Milica Labudovic-Borovic, Svetlana Trifunovic, Verica Milosevic, Dejan Lazic, Sergey Bolevich, Vladimir Jakovljevic and Zoran Milosavljevic
    Citation: Basic and Clinical Andrology 2021 31:17
    Content type: Research article Published on:

  24. Testicular sperm extraction (TESE) is the method of choice for recovering spermatozoa in patients with azoospermia. However, the lack of reliable biomarkers makes it impossible to predict sperm retrieval outco...

    Authors: Hamza Benderradji, Julie Prasivoravong, François Marcelli, Anne-Laure Barbotin, Sophie Catteau-Jonard, Carole Marchetti, Catherine Guittard, Philippe Puech, Valérie Mitchell, Jean-Marc Rigot, Arnauld Villers, Pascal Pigny and Clara Leroy
    Citation: Basic and Clinical Andrology 2021 31:15
    Content type: Research article Published on:

  25. The testis represents one place where the progenitor of vitamin D is converted into its active form. Loss of one testis was suggested to result in reduced vitamin D serum levels. Vitamin D deficiency would rep...

    Authors: Klaus-Peter Dieckmann, Osama Andura, Uwe Pichlmeier, Klaus Martin Otte, Hendrik Isbarn and Christian Wülfing
    Citation: Basic and Clinical Andrology 2021 31:14
    Content type: Research article Published on:

    The Correction to this article has been published in Basic and Clinical Andrology 2021 31:18

  26. Androgen deficiency affects men in the adulthood, causing several harmful effects at the reproductive and behavioural levels. Since aromatase is an enzyme that catalyses the conversion of androgens to estrogen...

    Authors: Giovanni Monastra, Mónica Vazquez-Levin, Maria Salome Bezerra Espinola, Gabriele Bilotta, Antonio Simone Laganà and Vittorio Unfer
    Citation: Basic and Clinical Andrology 2021 31:13
    Content type: Research article Published on:

  27. Sperm growth and maturation are correlated with the expression levels of Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1), a widely expressed protein in the human testicles. The decrease in LRWD1...

    Authors: Jui-Hsiang Hung, Han-Yi Cheng, Yung-Chieh Tsai, Hsien-An Pan, Hany A. Omar, Chien-Chih Chiu, Yin-Mei Su, Yung-Ming Lin and Yen-Ni Teng
    Citation: Basic and Clinical Andrology 2021 31:12
    Content type: Research article Published on:

  28. Diet, one of the components of lifestyle, has been believed to have associations with erectile dysfunction (ED). However, whether there is an association between plant-based diet and ED is remains to be explor...

    Authors: Yi Lu, Jiaqi Kang, Zhongjia Li, Xiao Wang, Kang Liu, Kechong Zhou, Wei Wang and Chen Shen
    Citation: Basic and Clinical Andrology 2021 31:11
    Content type: Research article Published on:

  29. Over the last years, there has been an increasing concern about a global decline in men’s fertility. Specifically, some evidence indicates that sperm quality has decreased over the last years. However, reports...

    Authors: Lucía Rosa-Villagrán, Natalibeth Barrera, José Montes, Carlos Riso and Rossana Sapiro
    Citation: Basic and Clinical Andrology 2021 31:8
    Content type: Research article Published on:

  30. Spermatogenesis is a complex process regulated by a multitude of genes. The identification and characterization of male-germ-cell-specific genes is crucial to understanding the mechanisms through which the cel...

    Authors: Hela Bellil, Farah Ghieh, Emeline Hermel, Béatrice Mandon-Pepin and François Vialard
    Citation: Basic and Clinical Andrology 2021 31:9
    Content type: Review article Published on:

  31. Occludin protein is the primary assembling protein of TJs and the structural basis for tight junction formation between Sertoli cells in the spermatogenic epithelium. The expression of miR-122-5p and occludin ...

    Authors: Limin Liu, Maoying Zhu, Xiaoli Liu, Lumin Fei, Jianyun Shen and Deyu Chen
    Citation: Basic and Clinical Andrology 2021 31:7
    Content type: Research article Published on:

  32. Ferroptosis is an iron-dependent cell death that is distinct from apoptosis. Based on excessive amounts of iron and reactive oxygen species in varicocele (VCL) rats, we hypothesize that ferroptosis might be in...

    Authors: Erfaneh Shaygannia, Mohammad H. Nasr-Esfahani, Fattah Sotoodehnejadnematalahi and Kazem Parivar
    Citation: Basic and Clinical Andrology 2021 31:10
    Content type: Research article Published on:

  33. Gonadotropin releasing hormone agonist (GnRHa) treatment following surgery to correct cryptorchidism restores mini-puberty via endocrinological and transcriptional effects and prevents adult infertility in mos...

    Authors: Faruk Hadziselimovic, Gilvydas Verkauskas and Michael B. Stadler
    Citation: Basic and Clinical Andrology 2021 31:6
    Content type: Review article Published on:

  34. Penile prothesis (PP) is the gold-standard treatment of drug-refractory erectile dysfunction (ED). While postoperative outcomes have been widely described in the literature, there are few data about patient sa...

    Authors: Valentine Frydman, Ugo Pinar, Maher Abdessater, William Akakpo, Pietro Grande, Marie Audouin, Pierre Mozer, Emmanuel Chartier-Kastler, Thomas Seisen and Morgan Roupret
    Citation: Basic and Clinical Andrology 2021 31:4
    Content type: Research article Published on:

  35. Premature ejaculation (PE) is a multifactorial problem with a complicated aetiology that has detrimental effects on female partners’ sexual function. However, there is a lack of studies on the relationship bet...

    Authors: Hu Li, Pan Gao, Jingjing Gao, Xu Wu, Guodong Liu, Yutian Dai, Hui Jiang and Xiansheng Zhang
    Citation: Basic and Clinical Andrology 2021 31:5
    Content type: Research article Published on:

  36. In a previous report, we investigated whether the size of male genitalia similarly exposed to serum testosterone during aging could change with age and found that penile length almost stopped increasing during...

    Authors: Hiroshi Ikegaya, Motofumi Suzuki, Hiroki Kondou, Taketo Kawai, Yusuke Sato, Tadaichi Kitamura and Haruki Kume
    Citation: Basic and Clinical Andrology 2021 31:3
    Content type: Research article Published on:

  37. Spermatic cord torsion (SCT) is a surgical emergency. Any delay in diagnosis or treatment may compromise the vital and functional prognosis of the testicle. The orchiectomy rate remains very high in the litera...

    Authors: Fasnéwindé Aristide Kabore, Klovis Klifford Kabore, Moussa Kabore, Brahima Kirakoya, Clotaire Yameogo, Bienvenue Désiré Ky and Barnabé Zango
    Citation: Basic and Clinical Andrology 2021 31:2
    Content type: Research article Published on:

  38. Approximately 2–10% of patients with varicocele complain of pain. Varicocelectomy for testicular pain is a surgical choice when conservative therapy fails to relieve the pain. Different variables have been rep...

    Authors: Abdullah Al-Gadheeb, Hossam S. El-Tholoth, Abdulaziz Albalawi, Abdulmajeed Althobity, Mussa AlNumi, Tala Alafraa and Amr Jad
    Citation: Basic and Clinical Andrology 2021 31:1
    Content type: Research article Published on:

  39. Idiopathic central precocious puberty (ICPP) is supposed to be non-existent in a context of testicular destruction that is typically present in Klinefelter syndrome (KS). Herein, we describe a rare case of ICP...

    Authors: Salwan Maqdasy, Bertrand Barres, Gaelle Salaun, Marie Batisse-Lignier, Celine Pebrel-Richard, Kelvin H. M. Kwok, André Labbé, Philippe Touraine, Florence Brugnon and Igor Tauveron
    Citation: Basic and Clinical Andrology 2020 30:19
    Content type: Case report Published on:

  40. Erectile dysfunction (ED) has a negative impact on ones’ relationships with poor quality of life as inevitable result. The effects of ED maybe worse in developing countries setting like Tanzania because men’s ...

    Authors: Kenan B. Nyalile, Emmanuel H. P. Mushi, Epiphania Moshi, Beatrice J. Leyaro, Sia E. Msuya and Orgeness Mbwambo
    Citation: Basic and Clinical Andrology 2020 30:20
    Content type: Research article Published on:

  41. In 1999, despite a longstanding use, the WHO manual for the examination of human semen finally proposed to assay several biochemical components of the seminal plasma for a functional exploration of the male ac...

    Authors: Safouane M. Hamdi, Erick Sanchez, Delphine Garimbay and Stéphanie Albarede
    Citation: Basic and Clinical Andrology 2020 30:18
    Content type: Research article Published on:

  42. Patients with proximal penile prosthetic cylindrical complications (PPPCC) can be treated with a direct crural technique without using the original traditional approach. In this article we present our novel di...

    Authors: Ahmed S. Zugail, Maher Abdessater, Abdulmajeed Althobity, Johnny Boustany, Mabel Nuernberg, Abdalla Alhammadi and Sébastien Beley
    Citation: Basic and Clinical Andrology 2020 30:17
    Content type: Research article Published on:

  43. The prevalence of low semen quality and the incidence of testicular cancer have been steadily increasing over the past decades in different parts of the World. Although these conditions may have a genetic or e...

    Authors: Rita Rahban and Serge Nef
    Citation: Basic and Clinical Andrology 2020 30:16
    Content type: Review article Published on:

  44. Germline mosaicism is considered to be a rare event. However, its occurrence is underestimated due to the limited availability of germ cells. The genomic variations that underlie this phenomenon comprise singl...

    Authors: Celine Chalas, Aline Receveur, Nelly Frydman, Nathalie Massin, Gerard Tachdjian, Veronique Drouineaud, Alexandra Benachi, Catherine Patrat and Francois Michael Petit
    Citation: Basic and Clinical Andrology 2020 30:14
    Content type: Research article Published on:

  45. Varicocele is one of the most common causes of reversible male infertility, and 15% of the varicocele patients with normal semen analysis are diagnosed as infertile. According to the current guidelines, varico...

    Authors: Ponco Birowo, J. Rahendra Wijaya, Widi Atmoko and Nur Rasyid
    Citation: Basic and Clinical Andrology 2020 30:15
    Content type: Review article Published on:

  46. Clomiphene citrate has been proposed as pre-treatment for infertile men with non-obstructive, testicular azoospermia (NOA) before surgery for testicular sperm extraction (TESE), especially when serum testoster...

    Authors: Daniela Fietz, Adrian Pilatz, Thorsten Diemer, Florian Wagenlehner, Martin Bergmann and Hans-Christian Schuppe
    Citation: Basic and Clinical Andrology 2020 30:13
    Content type: Case report Published on:

  47. The Sperm Chromatin Structure Assay (SCSA®), in addition to identifying the DNA Fragmentation Index (DFI) also identifies High DNA satiability (HDS), supposed to reflect the nuclear compaction of spermatozoa. ...

    Authors: Z. Mohammadi, M. Tavalaee, P. Gharagozloo, J. R. Drevet and M. H. Nasr-Esfahani
    Citation: Basic and Clinical Andrology 2020 30:12
    Content type: Research article Published on:

  48. Little is known about the histology of contralateral descended testes in boys with unilaterally absent testis. We investigated whether absence of one testis is associated with abnormal tissue architecture of t...

    Authors: Faruk Hadziselimovic, Gilvydas Verkauskas, Beata Vincel, Gunthild Krey and Zacharias Zachariou
    Citation: Basic and Clinical Andrology 2020 30:11
    Content type: Research article Published on:

  49. Benign prostatic hyperplasia (BPH) is one of the most common reproductive disorders in both male dogs and men. Finasteride, a synthetic inhibitor of the enzyme 5α-reductase, is widely used as medical treatment...

    Authors: Daniel S. R. Angrimani, Luana C. Bicudo, Nuria Llamas Luceño, Bruno R. Rui, Matheus F. Silva, João D. A. Losano, Bart Leemans, Ann Van Soom and Camila I. Vannucchi
    Citation: Basic and Clinical Andrology 2020 30:9
    Content type: Research article Published on:

  50. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) metamorphosed our medical practice. In early June 2020, more than 6,400,000 COVID-19 (coronavirus-19 disease) cases were diagnosed across the world ...

    Authors: S. Hamdi, M. Bendayan, E. Huyghe, J.-C. Soufir, E. Amar, R. El Osta, I. Plotton, C. Delalande, J. Perrin, C. Leroy, A. Bouker, H. Pons, H. Lejeune, G. Robin and F. Boitrelle
    Citation: Basic and Clinical Andrology 2020 30:10
    Content type: Letter to the Editor Published on:
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Basic and Clinical Andrology

ISSN: 2051-4190