Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9(12):e1001356.
Article
PubMed
PubMed Central
Google Scholar
Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19(3):221–31.
Article
CAS
PubMed
Google Scholar
Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010;93(7):2222–31.
Article
CAS
PubMed
Google Scholar
Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, et al. Impact of body mass index values on sperm quantity and quality. J Androl. 2006;27(3):450–2.
Article
PubMed
Google Scholar
Tunc O, Bakos HW, Tremellen K. Impact of body mass index on seminal oxidative stress. Andrologia. 2011;43(2):121–8.
Article
CAS
PubMed
Google Scholar
Dupont C, Faure C, Sermondade N, Boubaya M, Eustache F, Clément P, et al. Obesity leads to higher risk of sperm DNA damage in infertile patients. AJA. 2013;15(5):622–5.
CAS
PubMed
Google Scholar
Bakos HW, Henshaw RC, Mitchell M, Lane M. Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil Steril. 2011;95(5):1700–4.
Article
PubMed
Google Scholar
Taha EA, Sayed SK, Gaber HD, Abdel Hafez HK, Ghandour N, Zahran A, et al. Does being overweight affect seminal variables in fertile men? Reprod BioMed Online. 2016;33(6):703–8.
Article
PubMed
Google Scholar
Australian Bureau of Statistics. 4364.0.55.001 - National Health Survey: first results, 2017–18. http://www.abs.gov.au/ausstats/abs@.nsf/mf/4364.0.55.001. Accessed 1 Dec 2018
Mushtaq R, Pundir J, Achilli C, Naji O, Khalaf Y, El-Toukhy T. Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis. Reprod BioMed Online. 2018;36(4):459–71.
Article
PubMed
Google Scholar
Crean AJ, Senior AM. High-fat diets reduce male reproductive success in animal models: a systematic review and meta-analysis. Obes Rev. Epub ahead of print. https://www.urotoday.com/recent-abstracts/urologic-oncology/investigative-urology/110327-high-fat-diets-reduce-male-reproductive-success-in-animal-models-a-systematic-review-and-meta-analysis.html.
Kahn BE, Brannigan RE. Obesity and male infertility. Curr Opin Urol. 2017;27(5):441–5.
Article
PubMed
Google Scholar
Genser L, Aguanno D, Soula HA, Dong L, Trystram L, Assmann K, et al. Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes. J Pathol. 2018;246(2):217–30.
Article
CAS
PubMed
Google Scholar
Vors C, Pineau G, Drai J, Meugnier E, Pesenti S, Laville M, et al. Postprandial Endotoxemia linked with chylomicrons and lipopolysaccharides handling in obese versus lean men: a lipid dose-effect trial. J Clin Endocrinol Metab. 2015;100(9):3427–35.
Article
CAS
PubMed
Google Scholar
Tremellen K, Mcphee N, Pearce K. Metabolic endotoxaemia related inflammation is associated with hypogonadism in overweight men. Basic Clin Androl. 2017;27(1):5.
Article
PubMed
PubMed Central
Google Scholar
Tremellen K, McPhee N, Pearce K, Benson S, Schedlowski M, Engler H. Endotoxin-initiated inflammation reduces testosterone production in men of reproductive age. Am J Physiol Endoc M. 2018;314(3):E206–E13.
Google Scholar
Tremellen K. Gut endotoxin leading to a decline in gonadal function (GELDING) - a novel theory for the development of late onset hypogonadism in obese men. Basic Clin Androl. 2016;26:7.
Article
PubMed
PubMed Central
Google Scholar
Copeland S, Warren HS, Lowry SF, Calvano SE, Remick D, The I, et al. Acute inflammatory response to endotoxin in mice and humans. Clin Diagn Lab Immunol. 2005;12(1):60–7.
CAS
PubMed
PubMed Central
Google Scholar
Tremellen K. Oxidative stress and male infertility—a clinical perspective. Hum Reprod Update. 2008;14(3):243–58.
Article
CAS
PubMed
Google Scholar
Sarkar O, Bahrainwala J, Chandrasekaran S, Kothari S, Mathur P, Agarwal A. Impact of inflammation on male fertility. Frontiers in bioscience (Elite edition). 2010;3:89–95.
Google Scholar
Buch JP, Kolon TF, Maulik N, Kreutzer DL, Das DK. Cytokines stimulate lipid membrane peroxidation of human sperm. Fertil Steril. 1994;62(1):186–8.
Article
CAS
PubMed
Google Scholar
Martínez P, Proverbio F, Camejo MI. Sperm lipid peroxidation and pro-inflammatory cytokines. AJA. 2007;9(1):102–7.
PubMed
Google Scholar
Agarwal A, Aitken RJ, Alvarez JG. Studies on Men's Heahlth and fertility: Humana press; 2012.
Qian L, Shi Q, Gu Y, Song J, Zhou M, Hua M. The relationship between IL-17 and male infertility: semen analysis. Afr J Microbiol Res. 2012;6(27):5672–7.
CAS
Google Scholar
Fraczek M, Sanocka D, Kamieniczna M, Kurpisz M. Proinflammatory cytokines as an intermediate factor enhancing lipid sperm membrane peroxidation in in vitro conditions. J Androl. 2008;29(1):85–92.
Article
CAS
PubMed
Google Scholar
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–72.
Article
CAS
PubMed
Google Scholar
Azenabor A, Ekun AO, Akinloye O. Impact of inflammation on male reproductive tract. J Reprod Infertil. 2015;16(3):123.
PubMed
PubMed Central
Google Scholar
Aly HAA, El-Beshbishy HA, Banjar ZM. Mitochondrial dysfunction induced impairment of spermatogenesis in LPS-treated rats: modulatory role of lycopene. Eur J Pharmacol. 2012;677(1):31–8.
Article
CAS
PubMed
Google Scholar
Collodel G, Moretti E, Brecchia G, Kuželová L, Arruda J, Mourvaki E, et al. Cytokines release and oxidative status in semen samples from rabbits treated with bacterial lipopolysaccharide. Theriogenology. 2015;83(7):1233–40.
Article
CAS
PubMed
Google Scholar
Wang H, Yang L-L, Hu Y-F, Wang B-W, Huang Y-Y, Zhang C, et al. Maternal LPS exposure during pregnancy impairs testicular development, steroidogenesis and spermatogenesis in male offspring. PloS One. 2014;9(9):e106786–e.
Article
PubMed
PubMed Central
Google Scholar
Urata K, Narahara H, Tanaka Y, Egashira T, Takayama F, Miyakawa I. Effect of endotoxin-induced reactive oxygen species on sperm motility. Fertil Steril. 2001;76(1):163–6.
Article
CAS
PubMed
Google Scholar
Okazaki T, Mihara T, Shimada M, Ikeda C, Fujita Y, Negishi H, et al. Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis. Hum Reprod. 2011;26(10):2799–806.
Article
PubMed
PubMed Central
Google Scholar
Zorn B, Virant-Klun I, Meden-Vrtovec H. Semen granulocyte elastase: its relevance for the diagnosis and prognosis of silent genital tract inflammation. Hum Reprod. 2000;15(9):1978–84.
Article
CAS
PubMed
Google Scholar
World health organisation. BMI Classification Geneva 2006. http://apps.who.int/bmi/index.jsp?introPage=intro_3.html. Accessed 1 Aug 2017
World health organisation. WHO laboratory manual for the examination and processing of human semen. 2010. https://www.who.int/reproductivehealth/publications/infertility/9789241547789/en/. Accessed 11 Dec 2018
Google Scholar
Bakos HW, Thompson JG, Feil D, Lane M. Sperm DNA damage is associated with assisted reproductive technology pregnancy. Int J Androl. 2008;31(5):518–26.
Article
CAS
PubMed
Google Scholar
Fasano A. Gut permeability, obesity, and metabolic disorders: who is the chicken and who is the egg? Am J Clin Nutr. 2017;105(1):3–4.
Article
CAS
PubMed
Google Scholar
Held Hales K, Diemer T, Ginde S, Shankar BK, Roberts M, Bosmann HB, et al. Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein. Endocrinology. 2000;141(11):4000–12.
Article
Google Scholar
Moreno-Navarrete JM, Sabater M, Ortega F, Ricart W, Fernández-Real JM. Circulating Zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. PLoS One. 2012;7(5):e37160.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mokkala K, Pellonperä O, Röytiö H, Pussinen P, Rönnemaa T, Laitinen K. Increased intestinal permeability, measured by serum zonulin, is associated with metabolic risk markers in overweight pregnant women. Metab. 2017;69:43–50.
Article
CAS
Google Scholar
Raad G, Hazzouri M, Bottini S, Trabucchi M, Azoury J, Grandjean V. Paternal obesity: how bad is it for sperm quality and progeny health? Basic Clin Androl. 2017;27:20.
Article
PubMed
PubMed Central
Google Scholar
Żak-Gołąb A, Kocełak P, Aptekorz M, Zientara M, Juszczyk Ł, Martirosian G, et al. Gut microbiota, microinflammation, metabolic profile, and zonulin concentration in obese and normal weight subjects. Int J Endocrinol. 2013;2013. https://doi.org/10.1155/2013/674106.
Linninge C, Jönsson P, Bolinsson H, Önning G, Eriksson J, Johansson G, et al. Effects of acute stress provocation on cortisol levels, zonulin and inflammatory markers in low- and high-stressed men. Biol Psychol. 2018;138:48–55.
Article
PubMed
Google Scholar
Mokkala K, Eerola E, Munukka E, Röytiö H, Laitinen K, Ekblad U, et al. Gut microbiota richness and composition and dietary intake of overweight pregnant women are related to serum zonulin concentration, a marker for intestinal permeability. J Nutr. 2016;146(9):1694–700.
Article
CAS
PubMed
Google Scholar
Rato L, Alves MG, Cavaco JE, Oliveira PF. High-energy diets: a threat for male fertility? Obes Rev. 2014;15(12):996–1007.
Article
CAS
PubMed
Google Scholar
Pilatz A, Hudemann C, Wolf J, Halefeld I, Paradowska-Dogan A, Schuppe H-C, et al. Metabolic syndrome and the seminal cytokine network in morbidly obese males. Andrology. 2017;5(1):23–30.
Article
CAS
PubMed
Google Scholar
Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients. 2017;9(9):1021.
Article
PubMed Central
Google Scholar
Poutahidis T, Springer A, Levkovich T, Qi P, Varian BJ, Lakritz JR, et al. Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice. PLoS One. 2014;9(1):e84877.
Article
PubMed
PubMed Central
Google Scholar
Maretti C, Cavallini G. The association of a probiotic with a prebiotic (Flortec, Bracco) to improve the quality/quantity of spermatozoa in infertile patients with idiopathic oligoasthenoteratospermia: a pilot study. Andrology. 2017;5(3):439–44.
Article
CAS
PubMed
Google Scholar
Tremellen K, Pearce K. Probiotics to improve testicular function– a comment on mechanism of action and therapeutic potential of probiotics beyond reproduction. Andrology. 2017;5(5):1052–3.
Article
CAS
PubMed
Google Scholar
Wang HJ, Zakhari S, Jung MK. Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. WJG. 2010;16(11):1304–13.
Article
CAS
PubMed
Google Scholar
Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod BioMed Online. 2015;31(5):593–604.
Article
PubMed
Google Scholar
JBA O, Petersen CG, Mauri AL, Vagnini LD, Renzi A, Petersen B, et al. Association between body mass index and sperm quality and sperm DNA integrity. A large population study. Andrologia. 2018;50(3):e12889.
Article
Google Scholar
Ribas-Maynou J, García-Peiró A, Fernández-Encinas A, Abad C, Amengual MJ, Prada E, et al. Comprehensive analysis of sperm DNA fragmentation by five different assays: TUNEL assay, SCSA, SCD test and alkaline and neutral comet assay. Andrology-US. 2013;1(5):715–22.
Article
CAS
Google Scholar
Donkin I, Barrès R. Sperm epigenetics and influence of environmental factors. Mol Metab. 2018;14:1–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cho JW, Duffy JF. Sleep, sleep disorders, and sexual dysfunction. World J Mens Health. 2018;36. https://doi.org/10.5534/wjmh.180045.
Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, et al. Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol. 2017;68:3–33.
Article
CAS
PubMed
Google Scholar
de Punder K, Pruimboom L. Stress induces Endotoxemia and low-grade inflammation by increasing barrier permeability. Front Immunol. 2015;6:223.
Article
PubMed
PubMed Central
Google Scholar
Wiweko B, Anggraheni U, Elvira SD, Lubis HP. Distribution of stress level among infertility patients. Middle East Fertil Soc J. 2017;22(2):145–48