Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index), et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011;377(9765):557–67.
Article
PubMed
PubMed Central
Google Scholar
Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med. 2008;359(20):2105–20.
Article
CAS
PubMed
Google Scholar
Corona G, Vignozzi L, Sforza A, Mannucci E, Maggi M. Obesity and late-onset hypogonadism. Mol Cell Endocrinol. 2015;418(2):120–33.
Article
CAS
PubMed
Google Scholar
Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19(3):221–31.
Article
CAS
PubMed
Google Scholar
Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online. 2015;31(5):593–604.
Article
PubMed
Google Scholar
Cabler S, Agarwal A, Flint M, du Plessis SS. Obesity: modern man's fertility nemesis. Asian J Androl. 2010;12(4):480–9.
Article
PubMed
PubMed Central
Google Scholar
Auger J, Kunstmann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med. 1995;332(5):281–5.
Article
CAS
PubMed
Google Scholar
Kaukua J, Pekkarinen T, Sane T, Mustajoki P. Sex hormones and sexual function in obese men losing weight. Obes Res. 2003;11(6):689–94.
Article
CAS
PubMed
Google Scholar
Niskanen L, Laaksonen DE, Punnonen K, Mustajoki P, Kaukua J, Rissanen A. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. 2004;6(3):208–15.
Article
CAS
PubMed
Google Scholar
Schulte DM, Hahn M, Oberhäuser F, Malchau G, Schubert M, Heppner C, et al. Caloric restriction increases serum testosterone concentrations in obese male subjects by two distinct mechanisms. Horm Metab Res. 2014;46(4):283–6.
CAS
PubMed
Google Scholar
Saad F, Haider A, Doros G, Traish A. Long-term treatment of hypogonadal men with testosterone produces substantial and sustained weight loss. Obesity (Silver Spring). 2013;21(10):1975–81.
Article
CAS
Google Scholar
MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK. Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab. 1979;49(6):905–16.
Article
CAS
PubMed
Google Scholar
Loves S, Ruinemans-Koerts J, de Boer H. Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism. Eur J Endocrinol. 2008;158(5):741–7.
Article
CAS
PubMed
Google Scholar
Landry D, Cloutier F, Martin LJ. Implications of leptin in neuroendocrine regulation of male reproduction. Reprod Biol. 2013;13(1):1–14.
Article
PubMed
Google Scholar
Gautier A, Bonnet F, Dubois S, Massart C, Grosheny C, Bachelot A, et al. Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men. Clin Endocrinol (Oxf). 2013;78(3):373–8.
Article
CAS
Google Scholar
Foresta C, Di Mambro A, Pagano C, Garolla A, Vettor R, Ferlin A. Insulin-like factor 3 as a marker of testicular function in obese men. Clin Endocrinol (Oxf). 2009;71(5):722–6.
Article
CAS
Google Scholar
Winters SJ, Wang C, Abdelrahaman E, Hadeed V, Dyky MA, Brufsky A. Inhibin-B levels in healthy young adult men and prepubertal boys: is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells? J Androl. 2006;27(4):560–4.
Article
CAS
PubMed
Google Scholar
Andersen JM, Herning H, Aschim EL, Hjelmesæth J, Mala T, Hanevik HI, et al. Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range. PLoS One. 2015;10(6):e0130210. doi:10.1371/journal.pone.0130210.
Article
PubMed
PubMed Central
Google Scholar
Isidori AM, Caprio M, Strollo F, Moretti C, Frajese G, Isidori A, et al. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab. 1999;84(10):3673–80.
CAS
PubMed
Google Scholar
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tunc O, Bakos HW, Tremellen K. Impact of body mass index on seminal oxidative stress. Andrologia. 2011;43(2):121–8.
Article
CAS
PubMed
Google Scholar
Tremellen K. Oxidative stress and male infertility--a clinical perspective. Hum Reprod Update. 2008;14(3):243–58.
Article
CAS
PubMed
Google Scholar
Glade MJ, Smith K, Meguid MM. A glance at…nutritional antioxidants and testosterone secretion. Nutrition. 2015;31(10):1295–8.
Article
PubMed
Google Scholar
Jung A, Schuppe HC. Influence of genital heat stress on semen quality in humans. Andrologia. 2007;39(6):203–15.
Article
CAS
PubMed
Google Scholar
Bobjer J, Katrinaki M, Tsatsanis C, Lundberg Giwercman Y, Giwercman A. Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study. PLoS One. 2013;8(4):e61466. doi:10.1371/journal.pone.0061466.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsilidis KK, Rohrmann S, McGlynn KA, Nyante SJ, Lopez DS, Bradwin G, et al. Association between endogenous sex steroid hormones and inflammatory biomarkers in US men. Andrology. 2013;1(6):919–28.
Article
CAS
PubMed
Google Scholar
Grant JF, Martin SA, Taylor AW, Wilson DH, Araujo A, Adams RJ, et al. Cohort profile: The men androgen inflammation lifestyle environment and stress (MAILES) study. Int J Epidemiol. 2014;43(4):1040–53.
Article
PubMed
Google Scholar
Yeap BB, Knuiman MW, Divitini ML, Handelsman DJ, Beilby JP, Beilin J, et al. Differential associations of testosterone, dihydrotestosterone and oestradiol with physical, metabolic and health-related factors in community-dwelling men aged 17-97 years from the Busselton Health Survey. Clin Endocrinol (Oxf). 2014;81(1):100–8.
Article
CAS
Google Scholar
Cutolo M, Seriolo B, Villaggio B, Pizzorni C, Craviotto C, Sulli A. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann N Y Acad Sci. 2002;966:131–42.
Article
CAS
PubMed
Google Scholar
Zandman-Goddard G, Peeva E, Shoenfeld Y. Gender and autoimmunity. Autoimmun Rev. 2007;6(6):366–72.
Article
CAS
PubMed
Google Scholar
Neish AS. Microbes in gastrointestinal health and disease. Gastroenterology. 2009;136(1):65–80.
Article
PubMed
Google Scholar
Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. Annu Rev Pathol. 2010;5:119–44.
Article
CAS
PubMed
Google Scholar
Duerr CU, Hornef MW. The mammalian intestinal epithelium as integral player in the establishment and maintenance of host-microbial homeostasis. Semin Immunol. 2012;24(1):25–35.
Article
CAS
PubMed
Google Scholar
Laugerette F, Vors C, Peretti N, Michalski MC. Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation. Biochimie. 2011;93(1):39–45.
Article
CAS
PubMed
Google Scholar
Boutagy NE, McMillan RP, Frisard MI, Hulver MW. Metabolic endotoxemia with obesity: Is it real and is it relevant? Biochimie. 2016;124:11–20. doi:10.1016/j.biochi.2015.06.020.
Article
CAS
PubMed
Google Scholar
Raetz CR, Whitfield C. Lipopolysaccharide endotoxins. Annu Rev Biochem. 2002;71:635–700.
Article
CAS
PubMed
Google Scholar
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–72.
Article
CAS
PubMed
Google Scholar
Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, Alessi MC, Chamontin B, Ferriéres J. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr. 2008;87(5):1219–23.
CAS
PubMed
Google Scholar
Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009;58(8):1091–103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110(22):9066–71. doi:10.1073/pnas.1219451110.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57(6):1470–81.
Article
CAS
PubMed
Google Scholar
Cani PD, Osto M, Geurts L, Everard A. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes. 2012;3(4):279–88.
Article
PubMed
PubMed Central
Google Scholar
Basu S, Haghiac M, Surace P, Challier JC, Guerre-Millo M, Singh K, et al. Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation. Obesity (Silver Spring). 2011;19(3):476–82.
Article
CAS
Google Scholar
Kallio KA, Hätönen KA, Lehto M, Salomaa V, Männistö S, Pussinen PJ. Endotoxemia, nutrition, and cardiometabolic disorders. Acta Diabetol. 2015;52(2):395–404.
Article
CAS
PubMed
Google Scholar
Moreno-Navarrete JM, Ortega F, Serino M, Luche E, Waget A, Pardo G, et al. Circulatinglipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance. Int J Obes (Lond). 2012;36(11):1442–9. doi:10.1038/ijo.2011.256.
Article
CAS
Google Scholar
Tremellen K, Syedi N, Tan S, Pearce K. Metabolic endotoxaemia--a potential novel link between ovarian inflammation and impaired progesterone production. Gynecol Endocrinol. 2015;31(4):309–12.
Article
CAS
PubMed
Google Scholar
Kalliomäki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr. 2008;87(3):534–8.
PubMed
Google Scholar
Schwiertz A, Taras D, Schäfer K, Beijer S, Bos NA, Donus C, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring). 2010;18(1):190–5.
Article
Google Scholar
Burger-van Paassen N, Vincent A, Puiman PJ, van der Sluis M, Bouma J, Boehm G, et al. The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection. Biochem J. 2009;420(2):211–9.
Article
CAS
PubMed
Google Scholar
Vors C, Pineau G, Drai J, Meugnier E, Pesenti S, Laville M, et al. Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial. J Clin Endocrinol Metab. 2015;100(9):3427–35.
Article
CAS
PubMed
Google Scholar
Daniel JA, Abrams MS, de Souza L, Wagner CG, Whitlock BK, Sartin JL. Endotoxin inhibition of luteinizing hormone in sheep. Domest Anim Endocrinol. 2003;25(1):13–9.
Article
CAS
PubMed
Google Scholar
Shang T, Zhang X, Wang T, Sun B, Deng T, Han D. Toll-like receptor-initiated testicular innate immune responses in mouse Leydig cells. Endocrinology. 2011;152(7):2827–36.
Article
CAS
PubMed
Google Scholar
Bosmann HB, Hales KH, Li X, Liu Z, Stocco DM, Hales DB. Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic acute regulatory (StAR) protein in Leydig cells. Endocrinology. 1996;137(10):4522–5.
CAS
PubMed
Google Scholar
Hales KH, Diemer T, Ginde S, Shankar BK, Roberts M, Bosmann HB, et al. Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein. Endocrinology. 2000;141(11):4000–12.
Article
CAS
PubMed
Google Scholar
Allen JA, Diemer T, Janus P, Hales KH, Hales DB. Bacterial endotoxin lipopolysaccharide and reactive oxygen species inhibit Leydig cell steroidogenesis via perturbation of mitochondria. Endocrine. 2004;25(3):265–75.
Article
CAS
PubMed
Google Scholar
Bik W, Wolinska-Witort E, Chmielowska M, Baranowska-Bik A, Rusiecka-Kuczalek E, Baranowska B. Vasoactive intestinal peptide can modulate immune and endocrine responses during lipopolysaccharide-induced acute inflammation. Neuroimmunomodulation. 2004;11(6):358–64.
Article
CAS
PubMed
Google Scholar
Reddy MM, Mahipal SV, Subhashini J, Reddy MC, Roy KR, Reddy GV, et al. Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats. Reprod Toxicol. 2006;22(3):493–500.
Article
CAS
PubMed
Google Scholar
Hales DB. Testicular macrophage modulation of Leydig cell steroidogenesis. J Reprod Immunol. 2002;57(1-2):3–18.
Article
CAS
PubMed
Google Scholar
Ramonda R, Foresta C, Ortolan A, Bertoldo A, Oliviero F, Lorenzin M, et al. Influence of tumor necrosis factor α inhibitors on testicular function and semen in spondyloarthritis patients. Fertil Steril. 2014;101(2):359–65.
Article
CAS
PubMed
Google Scholar
Kerr JB, Millar M, Maddocks S, Sharpe RM. Stage-dependent changes in spermatogenesis and Sertoli cells in relation to the onset of spermatogenic failure following withdrawal of testosterone. Anat Rec. 1993;235(4):547–59.
Article
CAS
PubMed
Google Scholar
Fujita Y, Mihara T, Okazaki T, Shitanaka M, Kushino R, Ikeda C, et al. Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis. Hum Reprod. 2011;26(10):2799–806.
Article
CAS
PubMed
PubMed Central
Google Scholar
Harris CL, Vigar MA, Rey Nores JE, Horejsi V, Labeta MO, Morgan BP. The lipopolysaccharide co-receptor CD14 is present and functional in seminal plasma and expressed on spermatozoa. Immunology. 2001;104(3):317–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huleihel M, Lunenfeld E, Horowitz S, Levy A, Potashnik G, Mazor M, et al. Involvement of serum and lipopolysaccharide in the production of interleukin-1- and interleukin-6-like molecules by human sperm cells. Am J Reprod Immunol. 2000;43(1):41–6.
Article
CAS
PubMed
Google Scholar
Hosseinzadeh S, Pacey AA, Eley A. Chlamydia trachomatis-induced death of human spermatozoa is caused primarily by lipopolysaccharide. J Med Microbiol. 2003;52(3):193–200.
Article
CAS
PubMed
Google Scholar
Eley A, Hosseinzadeh S, Hakimi H, Geary I, Pacey AA. Apoptosis of ejaculated human sperm is induced by co-incubation with Chlamydia trachomatis lipopolysaccharide. Hum Reprod. 2005;20(9):2601–7.
Article
CAS
PubMed
Google Scholar
Kajihara T, Okagaki R, Ishihara O. LPS-induced transient testicular dysfunction accompanied by apoptosis of testicular germ cells in mice. Med Mol Morphol. 2006;39(4):203–8.
Article
CAS
PubMed
Google Scholar
Urata K, Narahara H, Tanaka Y, Egashira T, Takayama F, Miyakawa I. Effect of endotoxin-induced reactive oxygen species on sperm motility. Fertil Steril. 2001;76(1):163–6.
Article
CAS
PubMed
Google Scholar
Collodel G, Moretti E, Brecchia G, Kuželová L, Arruda J, Mourvaki E, et al. Cytokines release and oxidative status in semen samples from rabbits treated with bacterial lipopolysaccharide. Theriogenology. 2015;83:1233–40.
Article
CAS
PubMed
Google Scholar
Tremellen K, Tunc O. Macrophage activity in semen is significantly correlated with sperm quality in infertile men. Int J Androl. 2010;33(6):823–31.
Article
CAS
PubMed
Google Scholar
Frungieri MB, Calandra RS, Lustig L, Meineke V, Köhn FM, Vogt HJ, et al. Number, distribution pattern, and identification of macrophages in the testes of infertile men. Fertil Steril. 2002;78(2):298–306.
Article
PubMed
Google Scholar
Goluža T, Boscanin A, Cvetko J, Kozina V, Kosović M, Bernat MM, et al. Macrophages and Leydig cells in testicular biopsies of azoospermic men. Biomed Res Int. 2014;2014:828697. doi:10.1155/2014/828697.
Article
PubMed
PubMed Central
Google Scholar
Sokol RZ. It's not all about the testes: medical issues in Klinefelter patients. Fertil Steril. 2012;98(2):261–5.
Article
PubMed
Google Scholar
Olsen NJ, Kovacs WJ. Case report: testosterone treatment of systemic lupus erythematosus in a patient with Klinefelter's syndrome. Am J Med Sci. 1995;310(4):158–60.
Article
CAS
PubMed
Google Scholar
Schröder J, Kahlke V, Staubach KH, Zabel P, Stüber F. Gender differences in human sepsis. Arch Surg. 1998;133(11):1200–5.
Article
PubMed
Google Scholar
Schoeneberg C, Kauther MD, Hussmann B, Keitel J, Schmitz D, Lendemans S. Gender-specific differences in severely injured patients between 2002 and 2011: data analysis with matched-pair analysis. Crit Care. 2013;17(6):R277.
Article
PubMed
PubMed Central
Google Scholar
Folstad I, Karter AJ. Parasites, bright males and the immunocompetence handicap. The Am Naturalist. 1992;139(3):603–22.
Article
Google Scholar
Hausfater G, Watson DF. Social and reproductive correlates of parasite ova emissions by babonns. Nature. 1976;262(5570):688–9.
Article
CAS
PubMed
Google Scholar
Muehlenbein MP, Watts DP. The costs of dominance: testosterone, cortisol and intestinal parasites in wild male chimpanzees. Biopsychosoc Med. 2010;4:21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hosier DW, Durning JP. Involvement of sex hormones in the resistance of ICR mice to Nematospiroides dubius. Journal of Parasitology. 1975;63:564–6.
Article
Google Scholar
Huber SA, Job LP, Auld KR. Influence of sex hormones on Coxsackie B-3 virus infection in Balb/c mice. Cell Immunol. 1982;67(1):173–9.
Article
CAS
PubMed
Google Scholar
Nakanishi H, Horii Y, Terashima K, Fujita K. Effect of testosterone on the susceptibility of C57BL/6 mice to infection with Brugia pahangi with reference to inflammatory cell response. J Parasitol. 1989;75(3):455–60.
Article
CAS
PubMed
Google Scholar
Oakwood M, Bradley AJ, Cockburn A. Semelparity in a large marsupial. Proc Biol Sci. 2001;268(1465):407–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Humphries S, Stevens DJ. Reproductive biology. Out with a bang. Nature. 2001;410(6830):758–9.
Article
CAS
PubMed
Google Scholar
Fisher DO, Dickman CR, Jones ME, Blomberg SP. Sperm competition drives the evolution of suicidal reproduction in mammals. Proc Natl Acad Sci U S A. 2013;110(44):17910–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S. Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms. Brain Behav Immun. 2016;52:18–26.
Article
CAS
PubMed
Google Scholar
Bauer I, Bauer M, Raddatz A, Luedtke C, Werth M, Silomon M, et al. Influence of gender on stimulated cytokine response in patients with severe sepsis. Anaesthesist. 2006;55(5):515–27.
Article
CAS
PubMed
Google Scholar
MacLeod J, Hotchkiss R. The effect of hyperpyrexia upon spermatozoa counts in men. Endocrinology. 1941;10:333–9.
Google Scholar
Evenson DP, Jost LK, Corzett M, Balhorn R. Characteristics of human sperm chromatin structure following an episode of influenza and high fever: a case study. J Androl. 2000;21(5):739–46.
CAS
PubMed
Google Scholar
Carlsen E, Andersson AM, Petersen JH, Skakkebaek NE. History of febrile illness and variation in semen quality. Hum Reprod. 2003;18(10):2089–92.
Article
PubMed
Google Scholar
Sergerie M, Mieusset R, Croute F, Daudin M, Bujan L. High risk of temporary alteration of semen parameters after recent acute febrile illness. Fertil Steril. 2007;88(4):970.e1-7.
Article
PubMed
Google Scholar
Buch JP, Havlovec SK. Variation in sperm penetration assay related to viral illness. Fertil Steril. 1991;55(4):844–6.
Article
CAS
PubMed
Google Scholar
Zhou XP, Hu XL, Zhu YM, Qu F, Sun SJ, Qian YL. Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without hepatitis B. Asian J Androl. 2011;13(3):465–9.
Article
PubMed
PubMed Central
Google Scholar
Wang D, Li L, Xie Q, Hou Z, Yu X, Ma M, Huang T. Factors affecting sperm fertilizing capacity in men infected with HIV. J Med Virol. 2014;86(9):1467–72.
Article
CAS
PubMed
Google Scholar
Rochira V, Guaraldi G. Hypogonadism in the HIV-infected man. Endocrinol Metab Clin North Am. 2014;43(3):709–30.
Article
PubMed
Google Scholar
Aitken RJ, De Iuliis GN, McLachlan RI. Biological and clinical significance of DNA damage in the male germ line. Int J Androl. 2009;32(1):46–56.
Article
CAS
PubMed
Google Scholar
Schedlowski M, Engler H, Grigoleit JS. Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication. Brain Behav Immun. 2014;35:1–8.
Article
CAS
PubMed
Google Scholar
Ashley NT, Hays QR, Bentley GE, Wingfield JC. Testosterone treatment diminishes sickness behavior in male songbirds. Horm Behav. 2009;56(1):169–76.
Article
CAS
PubMed
Google Scholar
Grimes DA, Lopez LM, Gallo MF, Halpern V, Nanda K, Schulz KF. Steroid hormones for contraception in men. Cochrane Database Syst Rev. 2012;3:CD004316. doi:10.1002/14651858.CD004316.pub4.
PubMed
Google Scholar
Gloy VL, Briel M, Bhatt DL, Kashyap SR, Schauer PR, Mingrone G, et al. Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ. 2013;347:f5934. doi:10.1136/bmj.f5934.
Article
PubMed
PubMed Central
Google Scholar
Hammoud A, Gibson M, Hunt SC, Adams TD, Carrell DT, Kolotkin RL, et al. Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men. J Clin Endocrinol Metab. 2009;94(4):1329–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pellitero S, Olaizola I, Alastrue A, Martínez E, Granada ML, Balibrea JM, et al. Hypogonadotropic hypogonadism in morbidly obese males is reversed after bariatric surgery. Obes Surg. 2012;22(12):1835–42.
Article
PubMed
Google Scholar
Aarts E, van Wageningen B, Loves S, Janssen I, Berends F, Sweep F, et al. Gonadal status and outcome of bariatric surgery in obese men. Clin Endocrinol (Oxf). 2014;81(3):378–86.
Article
CAS
Google Scholar
Samavat J, Facchiano E, Lucchese M, Forti G, Mannucci E, Maggi M, et al. Hypogonadism as an additional indication for bariatric surgery in male morbid obesity? Eur J Endocrinol. 2014;171(5):555–60. doi:10.1530/EJE-14-0596.
Article
CAS
PubMed
Google Scholar
Håkonsen LB, Thulstrup AM, Aggerholm AS, Olsen J, Bonde JP, Andersen CY, et al. Does weight loss improve semen quality and reproductive hormones? Results from a cohort of severely obese men. Reprod Health. 2011;8:24. doi:10.1186/1742-4755-8-24.
Article
PubMed
PubMed Central
Google Scholar
Kolida S, Gibson GR. Synbiotics in health and disease. Annu Rev Food Sci Technol. 2011;2:373–93.
Article
PubMed
Google Scholar
Le Barz M, Anhê FF, Varin TV, Desjardins Y, Levy E, Roy D, et al. Probiotics as Complementary Treatment for Metabolic Disorders. Diabetes Metab J. 2015;39(4):291–303.
Article
PubMed
PubMed Central
Google Scholar
Ritze Y, Bárdos G, Claus A, Ehrmann V, Bergheim I, Schwiertz A, et al. Lactobacillus rhamnosus GG protects against non-alcoholic fatty liver disease in mice. PLoS One. 2014;9(1):e80169. doi:10.1371/journal.pone.0080169.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wu CC, Weng WL, Lai WL, Tsai HP, Liu WH, Lee MH, Tsai YC. Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice. Evid Based Complement Alternat Med. 2015;2015:391767.
PubMed
PubMed Central
Google Scholar
Wang J, Tang H, Zhang C, Zhao Y, Derrien M, Rocher E, et al. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J. 2015;9(1):1–15. doi:10.1038/ismej.2014.99.
Article
PubMed
CAS
Google Scholar
Minami J, Kondo S, Yanagisawa N, Odamaki T, Xiao JZ, Abe F, et al. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. J Nutr Sci. 2015;4:e17. doi:10.1017/jns.2015.5.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chen XL, Gong LZ, Xu JX. Antioxidative activity and protective effect of probiotics against high-fat diet-induced sperm damage in rats. Animal. 2013;7(2):287–92.
Article
CAS
PubMed
Google Scholar
Poutahidis T, Springer A, Levkovich T, Qi P, Varian BJ, Lakritz JR, et al. Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice. PLoS One. 2014;9(1):e84877. doi:10.1371/journal.pone.0084877.
Article
PubMed
PubMed Central
CAS
Google Scholar
Michielan A, D'Incà R. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015;2015:628157.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mehta NN, McGillicuddy FC, Anderson PD, Hinkle CC, Shah R, Pruscino L, et al. Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes. 2010;59(1):172–81.
Article
CAS
PubMed
Google Scholar
Veldhuis J, Yang R, Roelfsema F, Takahashi P. Proinflammatory Cytokine Infusion Attenuates LH's Feedforward on Testosterone Secretion: Modulation by Age. J Clin Endocrinol Metab. 2016;101(2):539–49.
Article
PubMed
CAS
Google Scholar