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Table 1 Selected hormonal values of the patient between 1997 and 2019

From: Testicular impairment in Primary Adrenal Insufficiency caused by Nicotinamide Nucleotide Transhydrogenase (NNT) deficiency a case report: implication of oxidative stress and importance of fertility preservation

 

FSH (IU/L)

LH (IU/L)

Serum total Testosterone (nmol/L)

Inhibin B (pg/mL)

ACTH (pmol/L)

Cortisol (nmol/L)

Normal range

1–6

0.8–6

11.8–34.5

28–267

 < 13.3

166–507

DATE

September-1997

4

5

13,18

 

108,3

 < 28

October-1999

5,2

7

11,09

 

166,3

 < 28

September-2001

4,8

7,8

4,51

 

916,1

 < 28

November-2002

5,5

11,6

9,36

 

867,7

28

May-2004

4,9

9,7

7,28

 

231,4

 < 28

April-2008

5,6

7

12,14

 

118,3

 

May-2010

5,5

8,6

11,09

 

1000

28

July-2013

19

12

5,82

14

198,9

 < 28

March-2014

28

13

6,24

 

2,2

 

March-2015

30,8

10,2

4,89

 

2

 

September-2017

2,4

0,66

5,91

 

566

 < 4

October-2019

0,5

0,5

7,9

 

155

 < 4

  1. Serum total testosterone was stable until 2010 (31 year-old), before decreasing, with higher gonadotrophin levels. ACTH levels were high except during the intensified glucocorticoid therapy (between August 2013 and March 2015)
  2. ACTH Adrenocorticotropic hormone, FSH Follicle stimulating hormone, LH Luteinizing hormone, IU international unit, nmol/L nanomoles per liter, pg/mL picograms per milliter, pmol/L picomoles per liter