Skip to main content

Table 2 Analysis of semen quality improvement by L-carnitine combined with Coenzyme Q10 supplementation in vitro semen of asthenozoospermia patients for an actual value at the end of the study

From: Studies on improving semen quality and increasing pregnancy chances through the in vitro addition of L-carnitine and coenzyme Q10 to semen in patients with asthenozoospermia

Groups Parameters

LC (n = 120)

CoQ10 (n = 120)

LC + CoQ10 (n = 120)

Blank control (n = 120)

F/χ2

P-value

Patient (Male) Age (Year)

31 (21, 47)

31 (21, 47)

31 (21, 47)

31 (21, 47)

0

1

The initial concentration of the added drug (mmol/l)

8

4

8,4

–

–

–

The initial volume of the added drug (ml)

2

2

1,1

–

–

–

The final concentration of added drug (mmol/l)

5.3 ± 0.4

2.7 ± 0.2

2.7 ± 0.2, 1.3 ± 0.1

–

–

–

Semen parameters (contains additives)

 Incubation time (Minute)

60

60

60

60

0

1

 Incubation temperature (°C)

37

37

37

37

0

1

 Semen volume (ml)

3.0 ± 0.2

3.0 ± 0.2

3.0 ± 0.2

3.0 ± 0.2

0

1

 pH

7.4 ± 0.1

7.4 ± 0.1

7.4 ± 0.1

7.4 ± 0.1

0.25

0.862

 Sperm concentration (106/ml)

15.6 ± 4.2

15.8 ± 4.1

16.5 ± 4.2

16.1 ± 3.8

0.994

0.395

Total sperm number (106)

48.3 ± 14.2

50.1 ± 14.5

47.6 ± 14.6

49.0 ± 13.5

0.658

0.578

Sperm morphology, %

  Normal

11 (6, 15)

10 (5, 15)

11 (6, 15)

10 (6, 14)

0.033

0.804

 Progressive sperm motility, %

24.3 ± 4.6b

23.0 ± 4.8a

28.4 ± 5.0c,d,e

19.7 ± 4.4

70.77

< 0.001

 Sperm motility, %

38.1 ± 5.1b

36.9 ± 4.4a

43.8 ± 5.4c,d,e

26.0 ± 4.9

269.29

< 0.001

  1. Data are presented as mean ± SD or as median (minimum, maximum)
  2. P-values were calculated using one-way analysis of variance (one-way ANOVA), and the Bonferroni t test was used for multiple comparisons. Among them, the effect of LC + CoQ10 on protects progressive sperm motility and sperm motility was different from that of LC, CoQ10 and blank control (all P < 0.05). It can be considered that the LC + CoQ10 is superior to the LC, CoQ10 in protecting sperm motility and live sperm rate
  3. The boldface represents statistical significance
  4. Abbreviations: LC L-carnitine, CoQ10 Coenzyme Q10, LC + CoQ10 L-carnitine combined with Coenzyme Q10, SD standard deviation, ml milliliter, l liter, pH acidity index
  5. aRepresents a significant difference between the CoQ10 group and the Blank control group
  6. brepresents a significant difference between the LC group and the Blank control group
  7. cRepresents a significant difference between the LC + CoQ10 group and the Blank control group
  8. dRepresents a significant difference between the LC + CoQ10 group and the CoQ10 group
  9. erepresents a significant difference between the LC + CoQ10 group and the LC group