Table 1 Comparison between clinical and hormonal profiles (whole cohort, n = 155) according to the etiology of azoospermia
OA n = 23 | Unexplained NOA n = 69 | Cryptorchidism NOA n = 25 | Cytotoxic NOA n = 8 | Genetic NOA n = 30 | |
|---|---|---|---|---|---|
Age at TESE (years) [median (IQR)] | 30 (28–35) | 34 (32-37.5) | 33 (31–37) | 28.5 (26.5–42.5) | 32.5 (29–37) |
P-value | - | *0.01 | ns | ns | ns |
Mean testicular volume (mL) [median (IQR)] | 19.5 (15.1–22) | 9 (6.5–13.4) | 7 (6.4–9.7) | 5.6 (3.5;11) | 3.5 (2.3–7.4) |
P-value | - | *<0.0001 | *<0.0001 | *<0.0001 | *<0.0001 **<0.0001 ***0.01 |
FSH (IU /L) [median (IQR)] | 3.1 (1.8–3.8) | 17.2 (13.3–21.5) | 23.3 (15.4–30) | 17.3 (9.7–32.4) | 24.8 (17.8–31.5) |
P-value | *<0.0001 | *<0.0001 | *0.0002 | *<0.0001 **0.01 | |
LH (IU /L) [median (IQR)] | 2.9 (2-3.7) | 6.3 (4.9–8.3) | 5.3 (4.6–9.7) | 7.2 (6.5–9.7) | 9.8 (4.7–13.8) |
P-value | *<0.0001 | *<0.0001 | *<0.0001 | *<0.0001 **0.04 | |
Testosterone (ng/ml) [median (IQR)] | 5.5 (4.2–7.1) | 4.3 (3.5-5) | 3.9 (2.4–4.8) | 4.5 (2.4–6.8) | 3.2 (2-4.7) |
P-value | *0.009 | *0.0007 | ns | *<0.0001 **0.02 | |
AMH (pmol/l) [median (IQR)] | 44.8 (36-72.3) | 30.1 (15.2–58.5) | 21.8 (13.2–35.1) | 26.7 (10.4–41.6) | 7.3 (1.7–24.4) |
P-value | *0.02 | *0.001 | *0.04 | *<0.0001 **<0.0001 ***0.04 | |
AMH/Testosterone [median (IQR)] | 1.1 (0.7–1.6) | 0.9 (0.5–1.9) | 0.7 (0.6–1.3) | 0.6 (0.4–1.3) | 0.2 (0.1–0.7) |
P-value | ns | ns | ns | *<0.0001 **<0.0001 ***0.005 | |
Inhibin B (pg/ml) [median (IQR)] | 166 (137–244) | 17 (10-32.5) | 11 (8-50.5) | 9.5 (9–38) | 9.5 (8-20.5) |
P-value | *<0.0001 | *<0.0001 | *<0.0001 | *<0.0001 **0.03 |