Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility

Table 7 Polymorphisms in TEX genes associated with azoospermia and/or infertility, according to the literature

*SNP ID*	*Study*	*TEX gene*	*Nucleotide change (according to transcript variant 1)*	*Protein change*	*Gnomad (https://gnomad.broadinstitute.org/) frequency in the general population*	*Significantly associated with male infertility*	*Population*
rs6525433	Zhang et al., 2015 [60]	TEX11	c.389A > G	p.Lys130Arg	0.125	Yes	Chinese
rs4844247			c.1351G > A	p.Glu451Lys	0.103	No
Association						Yes
rs323344	Aston et al., 2010 [16]	TEX15	c.5158 T > G	p.Leu1720Val	0.148	No	Caucasian
rs323345	Aston et al., 2010 [16]		c.5081A > G	p.Asn1694Ser	0.168	No	Caucasian
rs323347	Ruan et al., 2012 [22]		c.1459 T > C	p.Cys487Arg	0.255	Yes	Chinese
rs323346	Ruan et al., 2012 [22]		c.4252A > G	p.Ile1418Val	0.251	Yes
rs323346	Zhang et al., 2010 [60]		c.4252A > G	p.Ile1418Val	0.251	No

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