Fig. 1From: Genetic defects in human azoospermiaSchematic depiction of the structure of the ADGRG2 protein. Truncating mutations reported in OA patients are indicated. Yellow rectangles represent the seven transmembrane helices. ADGRG2 is also composed of a G-protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain containing a cysteine-rich GPCR proteolysis site (GPS), and an extracellular STP region (in grey)Back to article page