Fig. 1

Schematic depiction of the structure of the ADGRG2 protein. Truncating mutations reported in OA patients are indicated. Yellow rectangles represent the seven transmembrane helices. ADGRG2 is also composed of a G-protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain containing a cysteine-rich GPCR proteolysis site (GPS), and an extracellular STP region (in grey)