Understanding the seminal plasma proteome and its role in male fertility

Camargo, Mariana; Intasqui, Paula; Bertolla, Ricardo Pimenta

doi:10.1186/s12610-018-0071-5

Basic and Clinical Andrology

Table 1 Suggested biomarkers for different infertility factors. Tissue expression data was collected from the Human Protein Atlas [30] and Genecards [31] databases

From: Understanding the seminal plasma proteome and its role in male fertility

Gene name	Protein name	Infertility factor	Expression	References
Expressed in testes/epididymis but not in other male reproductive tissues
ALB	Albumin	Oxidative stress	Increased	[50]
CRISP1	Cysteine-rich secretory protein 1	Non-obstructive azoospermia	Increased	[42]
EDDM3A	Epididymal secretory protein E3-alpha	Sperm DNA fragmentation	Increased	[48]
FTMT	Mitochondrial ferritin	Sperm DNA fragmentation	Decreased	[49]
GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase testis specific	Obstructive azoospermia	Absent	[14]
HIST1H2BA	Histone H2B type 1-A	Obstructive azoospermia	Absent	[14]
LDHC	L-lactate dehydrogenase C chain	OAT	Absent	[40]
PGK2	Phosphoglycerate kinase 2	Obstructive azoospermia	Absent	[14]
TEX101	Testis-expressed sequence 101	Obstructive azoospermia	Absent	[14, 38,39,40]
TKTL1	Transketolase-like protein 1	NOA, OA	Absent	[40]
Expressed in different male reproductive tissues
ANXA7	Annexin-7	Low mitochondrial activity	Increased	[8]
CEP135	Centrosomal protein of 135 kDa	Non-obstructive azoospermia	Absent	[36]
CYCS	Cytochrome C	Asthenozoospermic	Increased	[49]
CLU	Clusterin isoform-1	Oligozoospermic	Decreased	[47]
COL6A2	Collagen alpha-2(VI) chain	Non-obstructive azoospermia	Exclusive	[41]
DJ1	Protein/nucleic acid deglycase DJ-1	Asthenozoospermia	Decreased	[44]
ERP44	Endoplasmic reticulum resident protein 44	Low mitochondrial activity	Increased	[8]
FN1	Fibronectin I isoform 3 preprotein	Oxidative stress	Decreased	[50]
GGT7	Gamma-glutamyltransferase 7	Non-obstructive azoospermia	Exclusive	[41]
GSTM3	Glutathione S-transferase Mu3	Low mitochondrial activity	Increased	[8]
LCN1	Lipocalin-1	OAT	Increased	[46]
LGALS3BP	Galectin 3 binding	Oxidative stress	Decreased	[50]
M2BP	Galectin-3-binding protein	OAT	Decreased	[46]
MIF	Macrophage migration inhibitory factor-1 peptide	Oxidative stress	Decreased	[50]
NPC2	Epididymal secretory protein E1	Obstructive azoospermia	Absent	[36]
NPC2	Epididymal secretory protein E1	OAT	Decreased	[46]
PLTP	Phospholipid transfer protein	Low acrosome integrity	Increased	[8]
PSMB5	Proteasome subunit alpha type-5	Sperm DNA fragmentation	Increased	[8]
RASGRF1	Raf-specific guanine nucleotide-releasing factor 1	Non-obstructive azoospermia	Absent	[36]
RNASE4	Ribonuclease 4	Sperm DNA fragmentation	Increased	[48]
SORD	Sorbitol dehydrogenase	Non-obstructive azoospermia	Exclusive	[41]
Not expressed in the testes but expressed in the epididymis or other male reproductive tissues
AZGP1	Zinc alpha-2-glycoprotein	Oligozoospermic	Increased	[47]
CST4	Cystatin S precursor	Oxidative stress	Increased	[50]
KLK3	Kallikrein-3	Oxidative stress	Increased	[50]
LTF	Lactotransferrin	Oxidative stress	Increased	[50]
MUC5B	Mucin-5B	Oxidative stress	Increased	[9]
PIP	Prolactin inducible protein	Non-obstructive azoospermia	Absent	[36]
PIP	Prolactin inducible protein	OAT	Increased	[46, 47]
STAB2	Stabilin-2	Non-obstructive azoospermia	Absent	[36]

*OAT Oligoasthenoteratozoospermia

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ISSN: 2051-4190

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