Is sperm FISH analysis still useful for Robertsonian translocations? Meiotic analysis for 23 patients and review of the literature

Table 4 Meiotic segregation of Robertsonian translocation carriers

Patient	% Alt	% Adjacent				% 3:0	% unbalanced
der(13;14)
	balanced	disomy 13	nullisomy 13	disomy 14	nullisomy 14	3:0	unbalanced
P1	72.76	6.34	8.21	2.99	6.72	2.99	27.24
P2	71.69	4.57	6.39	7.31	10.05	0.00	28.31
P3	64.94	4.60	15.52	8.62	5.75	0.57	35.06
P4	84.86	2.83	4.66	3.16	4.49	0.00	15.14
P5	85.95	2.42	5.82	2.75	3.07	0.00	14.05
P6	75.39	6.84	6.29	5.74	5.52	0.22	24.61
P7	78.52	7.21	6.38	3.52	4.36	0.00	21.48
P8	66.08	4.59	3.81	9.97	12.12	3.42	33.92
P9	60.69	13.08	3.15	7.75	7.27	8.06	39.31
Mean	73.43	5.83	6.69	5.76	6.59	1.70	26.57
der(13;15)
	balanced	disomy 13	nullisomy 13	disomy 15	nullisomy 15	3:0	unbalanced
P10	66.80	6.40	7.60	8.80	10.40	0.00	33.20
P11	68.94	4.61	7.01	4.81	14.63	0.00	31.06
P12	81.32	1.10	6.59	3.30	6.59	1.10	18.68
P13	50.92	9.17	12.84	10.09	16.97	0.00	49.08
P14	81.57	3.66	2.66	3.97	3.76	4.39	18.43
Mean ± SD	69.91	4.99	7.34	6.19	10.47	1.10	30.09
der(13;22)
	balanced	disomy 13	nullisomy 13	disomy 22	nullisomy 22	3:0	unbalanced
P15	72.78	4.63	9.51	4.39	8.05	0.73	27.32
der(14;15)
	balanced	disomy 14	nullisomy 14	disomy 15	nullisomy 15	3:0	unbalanced
P16	71.80	7.00	10.60	3.60	7.00	0.00	28.20
P17	83.90	0.85	4.24	0.21	10.81	0.00	16.10
P18	83.26	2.48	4.75	1.24	8.26	0.00	16.74
P19	68.26	5.49	4.51	7.33	12.56	1.85	31.74
Mean ± SD	76.80	3.95	6.03	3.10	9.66	0.46	23.20
der(14;21)
	balanced	disomy 14	nullisomy 14	disomy 21	nullisomy 21	3:0	unbalanced
P20	89.99	3.24	0.99	1.97	3.81	0.00	10.01
P21	53.34	11.35	28.46	3.11	0.00	3.73	46.66
P22	79.71	4.92	7.63	3.73	3.22	0.79	20.29
Mean ± SD	74.35	6.51	12.36	2.94	2.34	1.51	25.65
der(14;22)
	balanced	disomy 14	nullisomy 14	disomy 22	nullisomy 22	3:0	unbalanced
P23	76.09	5.07	5.92	4.21	6.78	1.93	23.91

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