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Fig. 1 | Basic and Clinical Andrology

Fig. 1

From: “This is where it all started” – the pivotal role of PLCζ within the sophisticated process of mammalian reproduction: a systemic review

Fig. 1

Schematic diagram of PLCζ domains. The most conserved region among PLCs is the XY linker region, which hydrolyses PIP2, which triggers the InsP3/Ca2+ pathway [26]. The EF regions, which enhance PLCζ stability and Ca2+ binding, significantly contribute to the high PLCζ sensitivity to Ca2+ [16]. Moreover, EF domains binding to the C2 region, bend the PLCζ to a specific configuration, which exposes the catalytic X and Y domains and enables efficient PIP2 hydrolysis [27]. The XY-linker domain is another key regulator of the catalytic domains

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