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Lamine C2 et spermatogenèse

Lamin C2 and spermatogenesis

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Résumé

Les lamines A/C sont des filaments intermédiaires présents dans les noyaux des cellules. Leurs rôles sont multiples et des mutations du gène LMNA sont à l’origine de nombreuses maladies appelées laminopathies. Dans les cellules germinales masculines, cette famille de protéines n’est représentée que par la lamine C2. Les données obtenues chez la souris démontrent l’importance de ces filaments dans le déroulement de la méiose masculine et présagent de l’existence d’un nouveau domaine d’infertilité d’origine masculine lié à des mutations de ce filament intermédiaire ou de ses protéines associées.

Abstract

Lamin A/C are intermediate filaments present in nucleus. Their roles are numerous and laminopathies are issued from LMNA gene mutations. In male germ cells, this protein family is only represented by lamin C2. The results obtained in male mice show the importance of these filaments in male meiosis and suggest the existence of a new male infertility domain involving this intermediate filament and its associated proteins.

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Correspondence to A. -M. Courtot.

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Courtot, A.-. Lamine C2 et spermatogenèse. Basic Clin. Androl. 22, 218–222 (2012) doi:10.1007/s12610-012-0188-x

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Mots clés

  • Lamine C2
  • Spermatogenèse
  • Laminopathie
  • Infertilité masculine

Keywords

  • Lamin C2
  • Spermatogenesis
  • Laminopathies
  • Male infertility