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Anticorps antispermatozoïdes : indications, étiologies et applications en 2011, de l’exploration de l’infertilité au concept d’immunocontraception masculine
Antisperm antibodies: screening and applications in 2011, from male inferility checkup to immunocontraceptive vaccine
Basic and Clinical Andrology volume 22, pages 20–28 (2012)
Résumé
La présente revue de la littérature a pour but de préciser en 2011 les techniques utilisées pour le dépistage des anticorps antispermatozoïdes (ACAS) et l’intérêt de ce dépistage dans diverses situations physiopathologiques mais aussi dans le choix du traitement des infertilités par les techniques d’assistance médicale à la procréation (AMP). De plus, l’étude des cibles et du rôle des ACAS dans l’infertilité a permis la mise au point d’un vaccin contraceptif masculin efficace dans certains modèles animaux et potentiellement utilisable chez l’homme.
Abstract
The present literature review aims at clarifying the techniques used in the screening of antisperm antibodies (ASAS), the value of screening at different physiological and pathological conditions, and the choice of infertility treatment in assisted reproduction. Moreover, studying the targets and the role of ASAS in infertility allowed for the development of antisperm contraceptive vaccines, which are found effective in some animal models and potentially usable in humans.
Abbreviations
- ABCD:
-
Agénésie bilatérale des canaux déférents
- ACAS:
-
Anticorps antispermatozoïdes
- AMP:
-
Assistance médicaleà la procréation
- CRISP1:
-
Cysteine rich secretory protein 1
- EPPIN:
-
Epididymal protease inhibitor
- IBT:
-
Immunobeads test
- ICSI:
-
Intracytoplasmic sperm injection
- MAR:
-
test, Mixed antiglobulin, reaction test
- TESE:
-
Testicular sperm extraction
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Tuech, J. Anticorps antispermatozoïdes : indications, étiologies et applications en 2011, de l’exploration de l’infertilité au concept d’immunocontraception masculine. Basic Clin. Androl. 22, 20–28 (2012). https://doi.org/10.1007/s12610-012-0165-4
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DOI: https://doi.org/10.1007/s12610-012-0165-4
Mots clés
- Anticorps antispermatozoïdes (ACAS)
- Implications cliniques
- Assistance médicale à la procréation (AMP)
- Infertilité immunologique
- Vaccination contraceptive
Keywords
- Antisperm antibodies (ASAS)
- Clinical implications
- Assisted reproduction
- Immunologic infertility
- Antisperm contraceptive vaccines