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Anticorps antispermatozoïdes : indications, étiologies et applications en 2011, de l’exploration de l’infertilité au concept d’immunocontraception masculine

Antisperm antibodies: screening and applications in 2011, from male inferility checkup to immunocontraceptive vaccine

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Résumé

La présente revue de la littérature a pour but de préciser en 2011 les techniques utilisées pour le dépistage des anticorps antispermatozoïdes (ACAS) et l’intérêt de ce dépistage dans diverses situations physiopathologiques mais aussi dans le choix du traitement des infertilités par les techniques d’assistance médicale à la procréation (AMP). De plus, l’étude des cibles et du rôle des ACAS dans l’infertilité a permis la mise au point d’un vaccin contraceptif masculin efficace dans certains modèles animaux et potentiellement utilisable chez l’homme.

Abstract

The present literature review aims at clarifying the techniques used in the screening of antisperm antibodies (ASAS), the value of screening at different physiological and pathological conditions, and the choice of infertility treatment in assisted reproduction. Moreover, studying the targets and the role of ASAS in infertility allowed for the development of antisperm contraceptive vaccines, which are found effective in some animal models and potentially usable in humans.

Abbreviations

ABCD:

Agénésie bilatérale des canaux déférents

ACAS:

Anticorps antispermatozoïdes

AMP:

Assistance médicaleà la procréation

CRISP1:

Cysteine rich secretory protein 1

EPPIN:

Epididymal protease inhibitor

IBT:

Immunobeads test

ICSI:

Intracytoplasmic sperm injection

MAR:

test, Mixed antiglobulin, reaction test

TESE:

Testicular sperm extraction

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Correspondence to J. Tuech.

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Tuech, J. Anticorps antispermatozoïdes : indications, étiologies et applications en 2011, de l’exploration de l’infertilité au concept d’immunocontraception masculine. Basic Clin. Androl. 22, 20–28 (2012) doi:10.1007/s12610-012-0165-4

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Mots clés

  • Anticorps antispermatozoïdes (ACAS)
  • Implications cliniques
  • Assistance médicale à la procréation (AMP)
  • Infertilité immunologique
  • Vaccination contraceptive

Keywords

  • Antisperm antibodies (ASAS)
  • Clinical implications
  • Assisted reproduction
  • Immunologic infertility
  • Antisperm contraceptive vaccines