Skip to main content

Advertisement

Anticorps antispermatozoïdes : indications, étiologies et applications en 2011, de l’exploration de l’infertilité au concept d’immunocontraception masculine

Antisperm antibodies: screening and applications in 2011, from male inferility checkup to immunocontraceptive vaccine

Basic and Clinical Andrologyvolume 22, pages20–28 (2012) | Download Citation

Article metrics

  • 3781 Accesses

Résumé

La présente revue de la littérature a pour but de préciser en 2011 les techniques utilisées pour le dépistage des anticorps antispermatozoïdes (ACAS) et l’intérêt de ce dépistage dans diverses situations physiopathologiques mais aussi dans le choix du traitement des infertilités par les techniques d’assistance médicale à la procréation (AMP). De plus, l’étude des cibles et du rôle des ACAS dans l’infertilité a permis la mise au point d’un vaccin contraceptif masculin efficace dans certains modèles animaux et potentiellement utilisable chez l’homme.

Abstract

The present literature review aims at clarifying the techniques used in the screening of antisperm antibodies (ASAS), the value of screening at different physiological and pathological conditions, and the choice of infertility treatment in assisted reproduction. Moreover, studying the targets and the role of ASAS in infertility allowed for the development of antisperm contraceptive vaccines, which are found effective in some animal models and potentially usable in humans.

Abbreviations

ABCD:

Agénésie bilatérale des canaux déférents

ACAS:

Anticorps antispermatozoïdes

AMP:

Assistance médicaleà la procréation

CRISP1:

Cysteine rich secretory protein 1

EPPIN:

Epididymal protease inhibitor

IBT:

Immunobeads test

ICSI:

Intracytoplasmic sperm injection

MAR:

test, Mixed antiglobulin, reaction test

TESE:

Testicular sperm extraction

Références

  1. 1.

    Shibahara H, Hirano Y, Shiraishi Y, et al (2006) Effects of in vivo exposure to eggs with sperm-immobilizing antibodies in follicular fluid on subsequent fertilization and embryo development in vitro. Reprod Med Biol 5:137–143

  2. 2.

    Zini A, Phillips S, Lefebvre J, et al (2010) Antisperm antibodies are not associated with sperm DNA damage: a prospective study of infertile men. J Reprod Immuno 85:205–208

  3. 3.

    Barthélémy C (2003) Indications for antisperm antibody testing. Andrologie 13:70–80.

  4. 4.

    Heidenreich A, Bonfig R, Wilbert DM, et al (1994) Risk factors for antisperm antibodies in infertile men. Am J Reprod immunol 31:69–76

  5. 5.

    Leushuis E, van der Steeg J, Steures P, et al (2009) Immunoglobulin G antisperm antibodies and prediction of spontaneous pregnancy. Fertil Steril 92:1659–1665

  6. 6.

    Hjort T (1998) Do autoantibodies to sperm reduce fecundity? A mini-review in historical perspective. Am J Reprod Immunol 40:215–222

  7. 7.

    De Almeida M (2003) Antisperm antibodies: critical evaluation of detection assays and clinical significance of antibodies to sperm surface antigens in infertile couples. Andrologie 13:63–

  8. 8.

    Mahmoud A, Comhaire F (2000) Antisperm antibodies: use of the mixed agglutination reaction (MAR) test using latex beads. Hum Reprod 15:231–233

  9. 9.

    Clarke G, Elliot P, Smalia C (1985) Detection of sperm antibodies in semen using the immunobead test. A survey using the immunobead test. Am J Reprod Immunol Microbial 7:118–123

  10. 10.

    Marconi M, Weidner W (2009) Site and risk factors of antisperm antibodies production in the male population. In: Krause W, Naz R (eds) Immune Infertility: the impact of immune reactions on human. Springer, Berlin, pp 97–109

  11. 11.

    Patrizio P, Moretti-Rojas I, Ord T, et al (1989) Low incidence of sperm antibodies in men with congenital absence of the vas deferens. Fertil Steril 52:1018–1021

  12. 12.

    Lee R, Goldstein M, Ullery B, et al (2009) Value of serum antisperm antibodies in diagnosing obstructive azoospermia. J Urol 181:264–269

  13. 13.

    Meinertz H, Linnet L, Fogh-Andersen P, et al (1990) Antisperm antibodies and fertility after vasovasostomy: a follow-up study of 216 men. Fertil Steril 54:315–321

  14. 14.

    Marconi M, Nowotny A, Pantke P, et al (2008) Antisperm antibodies detected by mixed agglutination reaction and immunobead test are not associated with chronic inflammation and infection of the seminal tract. Andrologie 40:227–234

  15. 15.

    Knudson G, Ross L, Stuhldreher D, et al (1994) Prevalence of sperm bound antibodies in infertile men with varicocele: the effect of varicocele ligation on antibody levels and semen response. J Urol 151:1260–1262

  16. 16.

    Cantatore C, Capuano P, Cobuzzi I, et al (2010) Semen quality and hormonal levels in infertile patients with varicocele. Arch Ital Urol Androl 82:291–293

  17. 17.

    Çetinkaya M, Memiş A, Adsan O, et al (1994) Antispermatozoal antibody values after varicocelectomy. International Urol Nephrol 26:89–92

  18. 18.

    Dohle G, Weidner W, Jungwirth A, et al (2004) EAU guidelines on male infertility. In: EAU Guidelines, European Association of Urology, pp 30–32

  19. 19.

    Sinisi A, Pasquali D, Papparella A, et al (1998) Antisperm antibodies in cryptorchidism before and after surgery. J Urol 160:1834–1837

  20. 20.

    Mirilas P, Panayiotides I, Mentessidou A, et al (2010) Effect of testis nondescent or orchidopexy on antisperm antibodies and testis histology in rats. Fertil Steril 4:1504–1509

  21. 21.

    Domagala A, Havryluk A, Nakonechnyj A, et al (2006) Antisperm antibodies in prepubertal boys with cryptorchidism. Arch Androl 52:411–416

  22. 22.

    Attia K, Zaki A, Eilts B, et al (2000) Antisperm antibodies and seminal characteristics after testicular biopsy or epididymal aspiration in dogs. Theriogenology 53:1355–1363

  23. 23.

    Komori K, Tsujimura A, Miura H, et al (2004) Serial follow-up study of serum testosterone and antisperm antibodies in patients with non-obstructive azoospermia after conventional or microdissection testicular sperm extraction. Int J Androl 27:32–36

  24. 24.

    Höbarth K, Klingler HC, Maier U, Kollaritsch H (1994) Incidence of antisperm antibodies in patients with carcinoma of the testis and in subfertile men with normogonadotropic oligoasthenoteratozoospermia. Urol Int 52:162–165

  25. 25.

    Paoli D, Gilio B, Piroli E, et al (2009) Testicular tumors as a possible cause of antisperm autoimmune response. Fertil Steril 91:414–419

  26. 26.

    Mulhall B, Fieldhouse S, Clark S, et al (1990) Antisperm antibodies in homosexual men: prevalence and correlation with sexual behaviour. Genitourin Med 66:5–7

  27. 27.

    Hirano Y, Shibahara H, Koriyama J, et al (2011) Incidence of sperm-immobilizing antibodies in infertile women with past Chlamydia trachomatis infection. Am J Reprod Immunol 65:127–132

  28. 28.

    Witkin S, Chaudhry A (1989) Circulating interferon-gamma in women sensitized to sperm: new mechanisms of infertility. Fertil Steril 52:867–869

  29. 29.

    Clarke G (2009) Etiology of sperm immunity in women. Fertil Steril 91:639–643

  30. 30.

    Bals-Pratsch M, Dören M, Karbowski B, et al (1992) Cyclic corticosteroid immunosuppression is unsuccessful in the treatment of sperm antibody-related male infertility: a controlled study. Hum Reprod 7:99–104

  31. 31.

    Alexander N, Sampson J, Fulgham D (1983) Pregnancy rates in patients treated for antisperm antibodies with prednisone. Int J Fertil 28:63–67

  32. 32.

    Grigoriou O, Konidaris S, Antonaki V, et al (1996) Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies. Eur J Obstet Gynecol Reprod Biol 65:227–302

  33. 33.

    Kutteh W, Byrd W, Blankenship L, et al (1996) Cervical mucus antisperm antibodies: treatment with intrauterine insemination. Am J Reprod Immunol 35:429–433

  34. 34.

    Check J (2010) Antisperm antibodies and human reproduction. Clin Exp Obstet Gynecol 37:169–174

  35. 35.

    Check J (2009) Sperm antibodies and assisted reproduction. In: Krause W, Naz R (eds) Immune infertility: the impact of immune reactions on human. Springer, Berlin, pp 175–184

  36. 36.

    Francavilla F, Santucci R, Barbonetti A, Francavilla S (2007) Naturally-occurring antisperm antibodies in men: interference with fertility and clinical implications. An update. Front Biosci 12:2890–2911

  37. 37.

    Zini A, Fahmy N, Belzile E, et al (2011) Antisperm antibodies are not associated with pregnancy rates after IVF and ICSI: systematic review and meta-analysis. Hum Reprod 26:1288–1295

  38. 38.

    Zini A, Lefebvre J, Kornitzer G, et al (2011) Antisperm antibody levels are not related to fertilization or pregnancy rates after IVF or IVF/ICSI. J Reprod Immunol 88:80–84

  39. 39.

    Mieusset R, Bujan L (1994) The potential of mild testicular heating as a safe, effective and reversible contraceptive method for men. Int J Androl 17:186–191

  40. 40.

    Huyghe E, Nohra J, Vezzosi D, et al (2007) Contraceptions masculines non déférentielles: revue de la littérature. Prog Urol 17:156–164

  41. 41.

    McLeskey SB, Dowds C, Carballada R, et al (1997) Molecules involved in mammalian Sperm-Egg interaction. International Rewiew of Cytology 177:57–113

  42. 42.

    Hamamah S, Jean M, Barrière P (2009) Interaction spermatozoïde-zone pellucide de l’ovocyte: importance dans l’immunocontraception. In: EMC (Elsevier Masson SAS), Paris, Gynécologie: 738-A-15

  43. 43.

    Cohen DJ, Maldera JA, Vasen G, et al (2011) Epididymal Protein CRISP1 Plays Different Roles During the Fertilization Process. J Androl 32:672–678

  44. 44.

    DaRos V, Maldera J, Willis W, et al (2008) Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1). Developmental Biology 320:12–18

  45. 45.

    Ellerman A, Cohen D, Weigel Munoz M, et al (2010) Immunologic behavior of human cysteine-rich secretory protein 1 (hCRISP1) in primates: prospects for immunocontraception. Fertil Steril 93: 2551–2556

  46. 46.

    O’Rand M, Widgren E, Sivashanmugam P, et al (2004) Reversible immunocontraception in male monkeys immunized with eppin. Science 306:1189–1190

  47. 47.

    O’Rand M, Widgren E, Beyler S, Richardson R (2009) PatInhibition of human sperm motility by contraceptive antieppin antibodies from infertile male monkeys: effect on cyclic adenosine monophosphate. Biol Reprod 80:279–285

  48. 48.

    Zhou CX, Zhang Y, Xiao L, et al (2004) An epididymis-specific beta-defensin is important for the initiation of sperm maturation. Nat Cell Biol 6:458–464

  49. 49.

    Xu W, Zhang X, Chen W, et al (2010) Immunization with Bin1b decreases sperm motility with compromised fertility in rats. Fertil Steril 93:952–958

  50. 50.

    Naz R (2011) Antisperm contraceptive vaccines: where we are and where we are going? Am J Reprod Immunol 66:5–12

Download references

Author information

Affiliations

  1. Laboratoire TOPBIO, 8, chemin de l’Ormeau, F-65000, Tarbes, France

    • J. Tuech

Authors

  1. Search for J. Tuech in:

Corresponding author

Correspondence to J. Tuech.

Rights and permissions

Reprints and Permissions

About this article

Mots clés

  • Anticorps antispermatozoïdes (ACAS)
  • Implications cliniques
  • Assistance médicale à la procréation (AMP)
  • Infertilité immunologique
  • Vaccination contraceptive

Keywords

  • Antisperm antibodies (ASAS)
  • Clinical implications
  • Assisted reproduction
  • Immunologic infertility
  • Antisperm contraceptive vaccines

Basic and Clinical Andrology

ISSN: 2051-4190