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Le cancer du testicule : facteurs de risque génétiques et environnementaux
Testicular cancer: genetic and environmental risk factors
Basic and Clinical Andrology volume 22, pages 10–19 (2012)
Résumé
L'incidence du cancer du testicule (CT), qui est inégale d'une région à l'autre, progresse dans la plupart des pays y compris la France. L'origine la plus probable du CT est la non différenciation de cellules germinales souches pendant la vie fœtale. Ces cellules, maintenues dans un état immature, pourraient proliférer pour former une tumeur après la puberté. La fréquence de son association avec une cryptorchidie ou une infertilité a conduit à formuler l'hypothèse que le CT pouvait être un des constituants du syndrome de dysgénésie testiculaire. Le rôle des facteurs génétiques est suggéré par la fréquence de cas familiaux de CT mais aucun gène clairement responsable du cancer n'a été identifié jusqu'à présent. Parmi les nombreux gènes étudiés, ce sont ceux contrôlant la voie KITLG/KIT, qui participe à la régulation de la prolifération et de la fonction des cellules germinales primordiales, qui semblent jouer le rôle principal. Les études faites sur des populations migrantes et les jumeaux suggèrent par ailleurs que des facteurs environnementaux pourraient jouer un rôle essentiel dans la genèse du CT. Des dérégulations hormonales pendant la vie fœtale ou la puberté pourraient notamment favoriser le développement de CT. Cependant, l'exposition à des substances exogènes agissant comme des perturbateurs endocriniens est encore à démontrer.
Abstract
The incidence of testicular cancer (TC) has a distinct geographic distribution but is increasing in most countries, including France. The most likely origin of TC is a lack of normal germ cell differentiation in the foetal testis. The maintained immature germ cells could proliferate after puberty to induce testicular tumor. Because of its frequent association with cryptorchidism and infertility, TC could be part of the testicular dysgenesis syndrome. The role of genetic factors is suggested by the frequency of familial TC cases, but no responsible gene has been clearly identified until now. Among the various studied genes, those regulating the KITLG/KIT pathway involved in primordial germ cell proliferation seem to play an important role. Studies made in immigrants and twins suggest the influence of environmental factors on the origin of TC. Hormonal deregulation occurring during prenatal life or puberty could facilitate the development of TC. However, the role of exogenous substances acting as endocrine disruptors has not been demonstrated yet.
Références
Rajpert-de Meyts E (2006) Developmental model for the pathogenesis of testicular carcinoma in-situ: genetic and environmental aspects. Hum Reprod Update 12:303–323
Oosterhuis JW, Looijenga LH (2005) Testicular germ-cell tumors in a broader perspective. Nat Rev Cancer 5:210–222
Horwich A, Shipley J, Huddart R (2006) Testicular germ-cell cancer. Lancet 367:754–765
Purdue MP, Devesa SS, Sigurdson AJ, McGlynn KA (2005) International patterns and trends in testis cancer incidence. Int J Cancer 115:822–827
Rosen A, Jayram G, Drazer M, Eggener SE (2011) Global trends in testicular cancer and mortality. Eur Urol 60:374–379
Bray F, Richiardi L, Ekbom A, et al (2006) Trends in testicular cancer incidence and mortality in 22 European countries: Continuing increases in incidence and decline in mortalities. Int J Cancer 118:3099–3111
Bergström R, Adami HO, Möhner M, et al (1996) Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J Natl Cancer Inst 88:727–733
Huyghe E, Plante P, Thonneau PF (2007) Testicular cancer variations in time and space in Europe. Eur Urol 51:621–628
Joffe M (2010) What has happened to human fertility? Hum Reprod 25:295–307
Bray F, Richiardi L, Ekbom A, et al (2006) Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality. Int J Cancer 118:3099–3111
Fédération Française des CECOS, Auger J, Jouannet P (1995) L'incidence du cancer du testicule augmente-t-elle en France ? La Presse Med 24:1133
Walschaerts M, Muller A, Daudin M, et al (2007) Sperm cryopreservation: recent and marked increase in use for testicular cancer compared with Hodgkin disease. J Androl 28:801–803
Walschaerts M, Huyghe E, Muller A, et al (2008) Doubling of testicular cancer incidence rate over the last 20 years in southern France. Cancer Causes Control 19:155–161
Belot A, Grosclaude P, Bossard N, et al (2008) Cancer incidence and mortality in France over the period 1980–2005. Rev Epidemiol Santé Publique 56:159–175
Kudjawu Y, Uhry Z, Danzon A, Bloch J (2011) Cancer du testicule: évolution nationale et variations régionales du taux de patients opérés 1998–2008 — Données hospitalières. Disponible sur: www.invs.sante.fr
Stevens LC, Little CC (1954) Spontaneous testicular teratomas in an inbred strain of mice. Proc Natl Acad Sci USA 40:1080–1087
Zechel JL, MacLennan GT, Heanney JT, Nadeau JH (2011) Spontaneous metatastasis in mouse models of testicular germcell tumors. Int J Androl 34:e278–e287
Anderson PD, Lam MY, Poirier C, et al (2009) The role of the mouse Y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69:3614–3618
Skakkebaek NE (1972) Possible carcinoma-in-situ of the testis. Lancet 516–517
Sonne SB, Almstrup K, Dalgaard M, et al (2009) Analysis of gene expression profiles of micro dissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res 69:5241–5250
Looijenga LHJ, Gillis AJM, Stoope H, et al (2011) Dissecting the molecukar pathways of (testicular) germ cell tumour pathogenesis; from initiation to treatment-resistance. Int J Androl 34:e234–e251
Lambrot R, Kimmins S (2010) Histone methylation is a critical regulator of the abnormal expression of POU5F1 an RASSF1A in testis cancer cell lines. Int J Androl 33:1–14
Cook MB, Akre A, Forman D, et al (2009) A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer — experiences of the mother. Int J Epidemiol 38:1532–1542
Cook MB, Akre A, Forman D, et al (2010) A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer — experiences of the son. Int J Epidemiol 39:1605–1618
Schnak TH, Poulsen G, Myrup G, et al (2010) Familial coaggregation of cryptorchidism, hypospadias and testicular germ-cell cancer: a nationwide cohort study. J Natl Cancer Inst 102:187–192
Richiardi L, Pettersson A, Akre O (2007) Genetic and environmental factors for testicular cancer. Int J Androl 30:230–241
Jacobsen R, Bostofte E, Engholm G, et al (2000) Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ 321:789–792
Jay DR, Craig FN, Goldstein M (2005) Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysis. J Urol 174:1819–1822
Skakkebaek NE, Rajpert-De Meyts E, Main KM (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16:972–978
Myrup C, Westegaard T, Schnak T, et al (2008) Testicular cancer risk in first- and second-generation immigrants to Denmark. J Natl Cancer Inst 100:41–47
Swerdlow AJ, De Stavola BL, Swanwick MA, Maconochie NE (1997) Risk of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology. Lancet 350:1723–1728
Hemminki K, Li X (2004) Familial risk in testicular cancer as a clue to a heritable and environmental aetiology. Br J Cancer 90:1765–1770
McGlynn KA, Devesa SS, Graubard BI, Castle PE (2005) Increasing incidence of testicular germ cell tumors among black men in the United-States. J Clin Oncol 23:5757–57561
Lutke Holzik MF, Rapleu EA, Horkstra AJ, et al (2004) Genetic predisposition to testicular germ-cell tumours. Lancet Oncol 5:363–372
Nathanson KL, Kanatsky PA, Hawes R, et al (2005) The Y deletion gr/gr and susceptibility to germ-cell tumor. Am J Hum Genet 77:1034–1043
Heimdal K, Olsson A, Tretli S, et al (1997) A segregation analysis of testicular cancer based on Norwegian and Swedish families. Br J Cancer 75:1084–1087
Horvath A, Korde L, Greene MH, et al (2009) Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors. Cancer Res 69:5301–5306
Turnbull C, Rahman N (2011) Genome-wide association studies provide new insight in the genetic basis of testicular germ-cell tumour. Int J Androl 34:e86–e96
Heaney JD, Lam MY, Michelson MV, Nadeau JH (2008) Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice. Cancer Res 68:5193–5197
Kristiansen W, Haugen TB, Witczak O, et al (2010) CYPA1, CYP3A5 and CYP3A7 polymorhisms and testicular cancer susceptibility. Int J Androl 34:77–83
Ferlin A, Ganz F, Pengo M, et al (2010) Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. Endocr Relat Cancer 17:17–25
Holl K, Lundin E, Surcel HM (2009) Endogenous steroid hormone levels in early pregnancy and risk of testicular cancer in the offspring: a nested case-reference study. Int J Cancer 124:2923–2928
Auger J, Eustache F (2011) Second to fourth digit ratios, male genital development and reproductive health: a clinical study among fertile men and testis cancer patients. Int J Androl 34: e49–e58
Shankar S, Davies S, Giller S, et al (2006) In utero exposure to female hormones and germ cell tumors in children Cancer 106:1169–1177
Sharp RM (2003) The “oestrogen hypothesis” — where do we stand now? Int J Androl 26:2–15
Trabert B, Sigurdson AJ, Sweeney AM, et al (2011) Baldness acne and testicular germ cell tumours. Int J Androl 34:e59–e67
Stang A, Ahrens W, Baumgardt-Elms C, et al (2006) Adolescent milk fat and galactose consumption and testicular germ cell cancer. Cancer Epidemiol Biomarkers Prev 15:2189–2195
Bouskine A, Nebout M, Mograbi B, et al (2008) Estrogens promote human testicular germ cell cancer through a membranemediated activation of extracellular regulated kinase and protein kinase A. Endocrinology 149:565–573
McGlynn KA, Quraishi SM, Graubard BI, et al (2008) Persistent organochlorine pesticide and risk of testicular gem cell tumors. J Natl Cancer Inst 100:663–671
Purdue MP, Engel LS, Langseth H, et al (2009) Prediagnostic serum concentrations of organochlorine compounds and risk of testicular germ cell tumors. Environ Health Perspect 117:1514–1519
Cohn BA, Cirillo PM, Christiansonn RE (2010) Prenatal DDT exposure and testicular cancer: a nested case-control study. Arch Environ Occup Health 65:127–134
Hardell L, Van Bavel B, Lindström G, et al (2003) Increased concentrations of polychlorinated biphenyls, hexachlorobenzen, and chlordanes in mothers of men with testicular cancer. Environ Health Perspect 111:930–934
McGlynn KA, Quraishi SM, Graubard BI, et al (2009) Polychlorinated biphenyls and risk of testicular germ cell tumors. Cancer Res 69:1901–1909
Hardell L, Van Bavel B, Lindström G, et al (2004) Concentrations of polychlorinated biphenyls in blood and the risk of testicular cancer. Int J Androl 27:282–290
Biggs ML, Davis MD, Eaton DL, et al (2008) Serum organochlorine pesticide residues and testicular germ cell carcinoma: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 17:2012–2018
Cook MB, Trabert B, McGlynn KA (2011) Organochlorine compounds and testicular dysgenesis syndrome: human data. Int J Androl 34:e68–e84
Chia VM, Li Y, Quraishi SM, et al (2010) Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes. Int J Androl 33:588–596
Bouskine A, Nebout M, Brücker-Davies F, et al (2009) Low doses of bisphenol A promote human sminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled to Estrogen receptor. Environ Health Perspect 117:1053–1058
Jobling MS, Hutchison GR, Van den Driesche S, Sharpe RM (2011) Effects of di (n-butyl) phtalate exposure on foetal rat germ-cell number and differentiation: identification of agespecific windows of vulnerability. Int J Androl 34(5 Pt 2): e386–e396
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Jouannet, P. Le cancer du testicule : facteurs de risque génétiques et environnementaux. Basic Clin. Androl. 22, 10–19 (2012). https://doi.org/10.1007/s12610-012-0164-5
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DOI: https://doi.org/10.1007/s12610-012-0164-5
Mots clés
- Cancer du testicule
- Épidémiologie
- Dysgénésie testiculaire
- Perturbateurs endocriniens
Keywords
- Testicular cancer
- Epidemiology
- Testicular dysgenesis
- Endocrine disruptors