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Cannabis et fertilité masculine

Cannabis and male fertility

Résumé

Le cannabis est la drogue récréative la plus utilisée dans le monde. Une des inquiétudes majeures de l’exposition au cannabis concerne son effet négatif sur la fonction reproductive. La découverte du système endocannabinnoïde, composé de multiples ligands endogènes lipidiques, leurs récepteurs et leurs enzymes métaboliques, a permis de mettre en évidence l’importance de la signalisation de ce système dans de multiples événements de la reproduction. Dans cet article, nous nous proposons de passer en revue la littérature sur l’impact du cannabis dans la fonction reproductive masculine. Nous aborderons les études réalisées chez l’homme et chez l’animal, et enfin nous discuterons les limites et perspectives des études envisageables pour évaluer les effets du cannabis sur la fertilité masculine.

Abstract

Cannabis is the most used recreational drug in the world. One of the major concerns of exposure to the cannabis is its negative effect on the reproductive function. The discovery of the endocannabinoid system, composed of multiple endogenous lipid ligands, their receptors and their metabolic enzymes, highlights the importance of the signaling pathways of this system in multiple events of reproduction. The objective of this study is to review the impact of the cannabis on male reproductive function. The limits and the perspective possible studies to evaluate the effects of the cannabis on male fertility are discussed in this study on the basis of the studies carried out on men and animals.

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Correspondence to Y. Alj.

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Mots clés

  • Cannabis
  • Endocannabinoïde
  • Reproduction
  • Infertilité

Keywords

  • Cannabis
  • Endocannabinoid
  • Reproduction
  • Infertility