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Une nouvelle fonction pour la transferrine exprimée par le testicule

A new function for transferrin expressed in testes

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Résumé

Chez l’homme, les oligospermies sévères sont associées à un faible taux de transferrine dans le liquide séminal. La transferrine apparaît comme un bon indicateur pour définir les dysfonctionnements testiculaires. Son niveau d’expression dans le testicule doit être parfaitement contrôlé. Elle y joue un rôl dans le transport du fer. Mais de récents résultats montrent l’existence d’une forme dimérique de la transferrine sertolienne comme puissant régulateur de la phagocytose des corps résiduels par les cellules de Sertoli.

Abstract

In men, oligozoospermia corresponds with a low level of transferrin in semen. Transferrin appears to be a relevant indicator of gonadal function. Transferrin expression in normal testes is perfectly controlled. Transferrin contributes to iron transport. However, recent results show the existence of a dimeric form, which acts as a powerful regulator of phagocytosis of residual bodies by Sertoli cells. A disturbance of this new highlighted function may account for some forms of oligozoospermia.

Abbreviations

ACTH:

adreno corticotropic hormone; hormone corticotrope

AMPc:

cyclic adenosine monophosphate; adénosine monophosphate cyclique

AP1:

activating protein 1; protéine d’activation 1

Axl:

receptor tyrosine-kinase, which regulates the phagocytic function; same tyrosine-kinase subfamily as Mer and Tyro-3-Sky; récepteur tyrosine-kinase régulant la phagocytose, même famille que Tyro3 et Mer

CD36:

cluster of differentiation 36; cluster de différenciation 36

COUP-TF:

chicken ovalbumin upstream promoter transcription factor; facteurs de transcription du promoteur de l’ovalbumine de poulet

CREB:

cAMP response element-binding; élément de réponse à l’AMPc

DMT1:

divalent metal transporter 1; transporteur membranaire du fer

EGF:

epidermal growth factor; facteur de croissance des cellules de l’épiderme

FGF:

fibroblast growth factor; facteur de croissance des fibroblastes

FSH:

follicle-stimulating hormone; hormone folliculostimulante

Gas6:

growth arrest-specific gene 6; gène 6 spécifique de l’arrêt de croissance

GH:

growth hormone; hormone de croissance

IGF:

insulin-like growth factor; facteur de croissance à l’insuline

IGF-BP:

insulin-like growth factor-binding protein; protéine de liaison des IGF

IL:

interleukines

LH:

luteinizing hormone; hormone lutéinisante

Mer:

receptor tyrosine-kinase (Mertk, Nyk, c-Eyk), which regulate the phagocytic function; same tyrosine-kinase subfamily as Axl3 and Tyro-3-Sky; récepteur tyrosine-kinase (Mertk, Nyk, c-Eyk) régulant la phagocytose, même famille que Tyro3 et Axl

Nramp2:

natural resistance associated macrophage protein 2; protéine associée aux macrophages de type 2

PModS:

peritubular factor that modulates sertoli cell function; facteurs péritubulaires modulant les fonctions sertoliennes

PR:

proximale region; région proximale

P450scc:

P450 cholesterol side-chain cleavage; protéine de clivage de la chaîne latérale du cholestérol

SE1:

specific element 1; élément spécifique 1

SHBG:

sex hormone-binding globulin; protéine de liaison aux stéroïdes

SIE:

cis-inductible element; élément cis-inductible

SRB1:

class B 1 scavenger receptor; récepteur scavenger de classe B

SRE:

serum response element; élément de réponse au sérum

StAR:

steroidogenic acute regulatory protein; protéine de régulation de la stéroïdogenèse

TGF:

transforming growth factor; facteur de différenciation

TNFα:

tumor necrosis factor alpha; facteur de nécrose tumoral alpha

TSH:

thyroïd stimulating hormone; thyréostimuline

Tyro3-Sky:

receptor tyrosine-kinase, which regulates the phagocytic function, same tyrosine-kinase subfamily as Axl3 and Mer; récepteur tyrosine-kinase régulant la phagocytose, même famille que Mer et Axl

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Correspondence to B. Fumel.

Additional information

Betty Fumel a obtenu le Prix Master SALF 2008.

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Fumel, B., Sow, A., Fouchécourt, S. et al. Une nouvelle fonction pour la transferrine exprimée par le testicule. Basic Clin. Androl. 19, 81–89 (2009) doi:10.1007/s12610-009-0013-3

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Mots clés

  • Transferrine
  • Testicule
  • Cellules de Sertoli
  • Phagocytose
  • Corps résiduel

Keywords

  • Transferrin
  • Testis
  • Sertoli cells
  • Phagocytosis
  • Residual bodies