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Une nouvelle fonction pour la transferrine exprimée par le testicule
A new function for transferrin expressed in testes
Basic and Clinical Andrology volume 19, pages 81–89 (2009)
Résumé
Chez l’homme, les oligospermies sévères sont associées à un faible taux de transferrine dans le liquide séminal. La transferrine apparaît comme un bon indicateur pour définir les dysfonctionnements testiculaires. Son niveau d’expression dans le testicule doit être parfaitement contrôlé. Elle y joue un rôl dans le transport du fer. Mais de récents résultats montrent l’existence d’une forme dimérique de la transferrine sertolienne comme puissant régulateur de la phagocytose des corps résiduels par les cellules de Sertoli.
Abstract
In men, oligozoospermia corresponds with a low level of transferrin in semen. Transferrin appears to be a relevant indicator of gonadal function. Transferrin expression in normal testes is perfectly controlled. Transferrin contributes to iron transport. However, recent results show the existence of a dimeric form, which acts as a powerful regulator of phagocytosis of residual bodies by Sertoli cells. A disturbance of this new highlighted function may account for some forms of oligozoospermia.
Abbreviations
- ACTH:
-
adreno corticotropic hormone; hormone corticotrope
- AMPc:
-
cyclic adenosine monophosphate; adénosine monophosphate cyclique
- AP1:
-
activating protein 1; protéine d’activation 1
- Axl:
-
receptor tyrosine-kinase, which regulates the phagocytic function; same tyrosine-kinase subfamily as Mer and Tyro-3-Sky; récepteur tyrosine-kinase régulant la phagocytose, même famille que Tyro3 et Mer
- CD36:
-
cluster of differentiation 36; cluster de différenciation 36
- COUP-TF:
-
chicken ovalbumin upstream promoter transcription factor; facteurs de transcription du promoteur de l’ovalbumine de poulet
- CREB:
-
cAMP response element-binding; élément de réponse à l’AMPc
- DMT1:
-
divalent metal transporter 1; transporteur membranaire du fer
- EGF:
-
epidermal growth factor; facteur de croissance des cellules de l’épiderme
- FGF:
-
fibroblast growth factor; facteur de croissance des fibroblastes
- FSH:
-
follicle-stimulating hormone; hormone folliculostimulante
- Gas6:
-
growth arrest-specific gene 6; gène 6 spécifique de l’arrêt de croissance
- GH:
-
growth hormone; hormone de croissance
- IGF:
-
insulin-like growth factor; facteur de croissance à l’insuline
- IGF-BP:
-
insulin-like growth factor-binding protein; protéine de liaison des IGF
- IL:
-
interleukines
- LH:
-
luteinizing hormone; hormone lutéinisante
- Mer:
-
receptor tyrosine-kinase (Mertk, Nyk, c-Eyk), which regulate the phagocytic function; same tyrosine-kinase subfamily as Axl3 and Tyro-3-Sky; récepteur tyrosine-kinase (Mertk, Nyk, c-Eyk) régulant la phagocytose, même famille que Tyro3 et Axl
- Nramp2:
-
natural resistance associated macrophage protein 2; protéine associée aux macrophages de type 2
- PModS:
-
peritubular factor that modulates sertoli cell function; facteurs péritubulaires modulant les fonctions sertoliennes
- PR:
-
proximale region; région proximale
- P450scc:
-
P450 cholesterol side-chain cleavage; protéine de clivage de la chaîne latérale du cholestérol
- SE1:
-
specific element 1; élément spécifique 1
- SHBG:
-
sex hormone-binding globulin; protéine de liaison aux stéroïdes
- SIE:
-
cis-inductible element; élément cis-inductible
- SRB1:
-
class B 1 scavenger receptor; récepteur scavenger de classe B
- SRE:
-
serum response element; élément de réponse au sérum
- StAR:
-
steroidogenic acute regulatory protein; protéine de régulation de la stéroïdogenèse
- TGF:
-
transforming growth factor; facteur de différenciation
- TNFα:
-
tumor necrosis factor alpha; facteur de nécrose tumoral alpha
- TSH:
-
thyroïd stimulating hormone; thyréostimuline
- Tyro3-Sky:
-
receptor tyrosine-kinase, which regulates the phagocytic function, same tyrosine-kinase subfamily as Axl3 and Mer; récepteur tyrosine-kinase régulant la phagocytose, même famille que Mer et Axl
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Betty Fumel a obtenu le Prix Master SALF 2008.
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Fumel, B., Sow, A., Fouchécourt, S. et al. Une nouvelle fonction pour la transferrine exprimée par le testicule. Basic Clin. Androl. 19, 81–89 (2009). https://doi.org/10.1007/s12610-009-0013-3
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DOI: https://doi.org/10.1007/s12610-009-0013-3