- Contraception
- Published:
Immunocontraception par la prévention de l’interaction gamétique
Immunoinhibition of fertilization by contraceptive vaccine
Andrologie volume 6, pages 274–281 (1996)
Resume
L’inhibition de l’action de molécules antigéniques d’origine spermatique ou ovocytaire impliquées dans le processus de la fécondation devient une cible attractive pour l’élaboration de vaccin contraceptif efficace, spécifique et réversible pour les pays en voie de dévéloppement.
Des approches variées à but contraceptif ont été utilisées pour indentifier à partir de spermatozoïdes des antigènes impliqués dans l’interaction gamétique et biologiquement importants. Mais, les travaux les plus avancés sur l’effet immunocontraceptif ne concernent que peu d’antigènes spermatiques comme candidats potentiels. En effet, parmi les antigènes du gamète mâle qui ont été identifiés on trouve l’antigène-1 (FA-1) de nature glycoprotéique, isolé du testicule humain, inhibant la fixation des spermatozoïdes sur la ZP. Mais un tel antigène n’est pas spécifique d’espèce. Chez le lapin, une famille antigénique RSA-1, 2, 3 dont les anticorps anti RSA sont capables d’inhiber la fusion entre la membrane plasmique du spermatozoïde (région post-acrosomique) et la membrane plasmique de l’ovocyte. Au total, la plupart des travaux met en évidence le rôle d’inhibition de la liaison spermatozoïdes-zone pellucide que jouent les anticorps anti-spermatozoïdes. Cependant, seuls deux antigènes spermatiques HS-63 et SP-10 ont été retenus par l’OMS comme candidats potentiels à la contraception.
Abstract
The paper summarize the main data relevant to the obtention of contraceptive vaccines based on spermatozoa as well as zona pellucida antigens. The development of novel forms of contraception is one way in which this global population problems can be tackled. The sperm as well as the oocyte antigens are studied as possible contraceptive vaccine candidates are the subject of this review.
References
Bleil JD, Wassarman PM: Structure and function of the zona pellucida: identification and characterization of the proteins of the mouse oocyte’s zona pellucida. Dev. Biol 1980; 76: 185–203.
Bleil JD, Wassarman PM: Identificate of ZP3-binding protein on acrosome intact mouse sperm by photoaffinity crosslinking. Proc; Nat. Acad. Sci. (USA) 1990; 87: 5563–5567.
Caudle MR, Shivers CA, Wild RA: Clinical significance of naturally occuring anti-zona pellucida antibodies. Am. J. Reprod. Immunol. Microbio 1987; 15: 119–121.
Drell DW, Dunbar BS: Monoclonal antibodies to rabbit and pig zonae pellucidae distinguish species-specific and shared antigenic determinants. Biol. Reprod 1984; 30: 445–457.
Gwatkin RBL, Williams DT, Carlo DJ: Immunization of mice with heat-solubilized hamster zonae: production of anti-zona antibody and inhibition of fertility. Fertil. Steril 1977; 28: 871–877.
Gwatkin RBL, Williams DT, Meyenhofer M.: Isolation of bovine zona pellucida from ovaries with collagenase: antigenic and sperm receptor properties. Gamete Res 1979; 2: 187–194.
Herr JC, Wright RM, John E, Foster J, Kays T, Flickinger CJ: Identification of human acrosomal antigen SP-10 in primates and pigs. Biol. Reprod 1990: 42: 377–382.
Jones R, Brown CR, Lancaster RT: Carbohydrate binding properties of boar sperm proacrosin and assessment of its role in sperm-egg recognition and adhesion during fertilization. Development 1988; 102: 781–792.
Kopf GS, Wilde MW: Signal transduction processes leading to acrosomal exocytosis in Mammalian spermatozoa. TEM Septembe/October. Elsevier, Science, Publishing Co, 1990; 362–368.
Koyama K, Hasegawa A, Inoue M, Isojma S: Blocking of human-sperm zona interaction by monoclonal antibodies to a glycoprotein family (ZP4) of porcine zona pellucida. Biol. Reprod 1991; 45: 727–7345.
Lee SL, Wei YH: The involvement of extracellular proteinases and proteinases inhibitors in mammalian fertilization. Biotechnol. Appled. Biochem 1984; 19: 31–41.
Leyton L, Saling PM: 95kD sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Cell 1989; 57: 1123–1130.
Lopez LC, Bayna EM, Litoff D, Shaper NL, Shaper JH, Shur BD: Receptor function of mouse sperm surface galactosyl-transferase during fertilization. J. Cell. Biol 1985; 101: 1501–1510.
Macek MB, Shur BD: Protein carbohydrate complementary in mammalian gamete recognition. Gamete. Res 1988; 20: 93–109.
Moller CC, Wassarmann PM: Characterization of a proteinase that cleaves zona pellucida glycoprotein ZP2 following activation of mouse eggs. Dev. Biol 1989; 132: 103–112
Naz RK, Alexander NJ, Isahakia M: Monoclonal antibody to a human germ cell membrane glycoprotein that inhibts fertilization. Science 1984; 22: 342–344.
O’Rand MG, Matthews JE, Welch JE, Fisher SJ: Identification of zona binding proteins of rabbit, pig, human and mouse spermatozoa on nitrocellulose blots. J. Exp. Zool 1985; 235: 423–428.
O’Rand MG, Widgreen EE, Nikolajczyk BS, Richardson RT, Shabanowitz RB: Receptors for zona pellucida on human spermatozoa. In: Gamete interaction: Prospects for immunocontraception, Wiley-Liss Inc 1990; 213–224.
Paterson M, Koothan PT, Morris KD, O’Byrne KT, Braude P, Williams A, Aitken RJ: Analysis of the contraceptive potential of antibodies against native and degly cosylated porcine ZP3 in vivo and in vitro. Biol. Reprod 1992; 46: 523–534.
Primakoff P, Lathrop W, Woolman L, Cowan A, Myles DG: Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Nature 1988; 335: 543–656.
Primakoff P, Myles DG: Selection of appropriate sperm antigens and animal models for developing an anti-sperm contraceptive vaccine. In: Bacetti B (ed.). Comparative Spermatology. 20 years after. NY: Raven Press 1992; 887–892.
Sacco AG: Antigenic cross-reactivity between human and pig zona pellucida. Biol. Reprod 1977; 16: 164–168.
Sacco AG: Inhibition of fertility in mice by passive immunization with antibodies to isolated zonae pellucidae. J Reprod. Fert 1979; 56: 533–537.
Sacco AG, Yurewicz EC, Subramanian MG, De Mayo FJ: Zona pellucida composition: species cross-reactivity and contraceptive potential of antiserum to a purified pig zona antigen (PPZA). Biol. Reprod 1981; 25: 997–1108.
Sanz L, Calvete JJ, Mann K, Schafer W, Schmid ER, Amselgruber W, Sinowatz F, Ehrhard M, Toper-Peterson E: The complete primary structure of spermadhesion AWN, a zona pellucida-binding protein isolated from boar spermatozoa. FEBS. Lett. 1992; 300: 213–218.
Shabanowitz RB, O’Rand MG: Characterization of the human zona pellucida from fertilized and unfertilized eggs. J. Reprod. Fertil. 1988; 82: 151–161.
Shbanowitz RB: Mouse antibodies to human zona pellucida: evidence that human ZP3 is strongly immunogenic and contains two disctinct isomer chains. Biol. Reprod 1990; 43: 260–270.
Shivers CA, Dunbar BS: Autoantibodies to zona pellucida: a possible cause for infertility in women. Science. 1977; 197; 1082–1084.
Shivers CA, Gengosian N, Franklin S, MC Laughlin, CA: Antigenic cross-reactivity between human and marmoset zonae pellucidae, a potential target for immunocontraception. J. Med. Primat. 1978; 7: 242–248.
Shur BD, Neely CA: Plasma membrane association, purification, and partial characterization of mouse sperm b 1,4-galactosyltransferase. J. Biol. Chem. 1988; 263: 17706–17714.
Tsunoda Y, Chang MC: In vivo and in vitro fertilization of hamster, rat and mouse eggs for treatment with anti-hamster ovary antiserum. J. Exp. Zool. 1976a; 195: 409–413.
Tsunoda Y, Chang MC: Effect of anti-rat ovary antiserum on the fertilization of rat, mouse and hamstereggs in vivo and in vitro. Biol. Reprod. 1976b; 14: 354–361.
Tsunoda Y, Chang, MC: Effects of antisera on fertilization of mouse, rat and hamster eggs. Biol. Reprod. 1978; 18: 468–474.
Tulsiani DRP, Skudlarek MD, Orgebin-Crist MC: Human sperm plasma membrane possess alpha-D-mannosidase activity but no galactosyl-transferase activity. Biol. Reprod. 1990; 42: 843–858.
WASSARMAN PM, BLEIL JD, FLORMAN HM, GREVE JM, ROLLER RJ, SALZMANN GS: Nature of the mouse egg’s receptor for sperm. In: Hedrick JL ed, The molecular and cellular biology of fertilization, New York, Plenum Press, 1986; 55–77.
Wood DM, Dunbar BSI: Direct detection of two cross-reactive antigens between porcine and rabbit zonae pellucidae by radioimmuoassay and immunoelectrophoresis. J. Exp. Zool. 1981; 217: 423–433.
Yanagimachi R: Mammalian fertilization. In: The physiology of reproduction. Knobil E, Neill J eds, New-York, Raven Press Ltd, 1994; 189–232.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hammah, S., Jean, M. & Barrière, P. Immunocontraception par la prévention de l’interaction gamétique. Androl. 6, 274–281 (1996). https://doi.org/10.1007/BF03035281
Issue Date:
DOI: https://doi.org/10.1007/BF03035281
Mots clés
- immunocontraception
- contraception
- antigènes
- spermatozoïde
- zone pellucide
Key Words
- immunoinhibition of fertilization
- contraceptive vaccine
- spermatozoon
- zona pellucida
- antigens