Skip to main content

La nutraceutiques (alicaments) et compléments alimentaires dans le traitement de l’infertilité masculine

Nutraceuticals and food supplementation for the treatment of the subfertile male


Plusieurs essais contrôlés et correctement validés apportent des preuves que des compléments alimentaires contenant des substances particulières peuvent améliorer la qualité et la fonction spermatiques d’hommes hypofertiles. Parmi ces compléments figurent les antioxydants astaxanthine, tocophérols et ubiquinone Q10, des acides gras essentiels du groupe oméga 3, le zinc et l’acide folique. Il y a des études qui suggèrent que certains extraits de plantes et des lignans ont également des effets bénéfiques. L’administration d’un nutraceutique (Qualisperm ®, Nutriphyt, Oostkamp, Belgique) contenant ces substances augmente la probabilité d’une conception spontanée et d’une grossesse menée à terme. Bien que les mécanismes exacts de l’action de ces compléments alimentaires sur la spermatogenèse et la fonction spermatique n’aient pas encore été entièrement découverts, il semble concevable que ces compléments agissent directement sur les cellules de Sertoli et améliore la fonction épididymaire. En tant que compléments alimentaires exempts de toute toxicité, les nutraceutiques devraient également être pris en considération avant de procéder à une fertilisation in vitro et à une ICSI, afin de réduire les dégâts oxydatifs à l’ADN des spermatozoïdes.


Several controlled and well-validated trials provide evidence that food supplementation with particular substances can improve semen quality and function of subfertile men. These include the antioxidants astaxanthin, tocopherols and ubiquinone Q10, essential fatty acids of the omega-3 group, zinc, and folic acid. There is suggestive evidence that certain plant extracts and lignans may equally exert beneficial effects. Supplementation with a nutraceutical (Qualisperm®, Nutriphyt, Oostkamp, Belgium) containing these substances increases the probability of spontaneous conception and successful pregnancy. Although the exact mechanisms of action of these supplements on spermatogenesis and sperm function remain to be unravelled, a direct effect on the cells of Sertoli and via epididymal function seems conceivable. Nutraceutical food supplementation should also be considered beforein vitro fertilization and ICSI, in order to reduce the oxidative damage to sperm DNA.


  1. 1.

    ADLERCREUTZ H., BANNWART C., WAHALA K. et al.: Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J. Steroid Biochem. Mol. Biol., 1993, 44: 147–153.

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    AYDIN S., INCI O., ALAGOL B.: The role of arginine, indomethacin and kallikrein in the treatment of oligoasthenospermia. Int. Urol. Nephrol., 1995, 27: 199–202.

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    BARTELLINI M., CANALE D., IZZO P.L., GIORGI P.M., MESCHINI P., MECHINI-FABRIS G.F.: L-carnitine and acetylcarnitine in human sperm with normal and reduced motility. Acta Eur. Fertil., 1987, 18: 29–31.

    PubMed  CAS  Google Scholar 

  4. 4.

    BAUMANN J., VON BRUCHHAUSEN F., WURM G.: Flavonoids and related compounds as inhibition of arachidonic acid peroxidation. Prostaglandins, 1980, 20: 627–639.

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    BERNARD D., CHRISTOPHE A., DELANGHE J., LANGLOIS M., DE BUYZERE M., COMHAIRE F.: The effect of supplementation with an antioxidant preparation on LDL-oxidation is determined by haptoglobin polymorphism. Redox. Rep., 2003, 8: 41–46.

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    BONDE J.P., JOFFE M., APOSTOLI P. et al.: Sperm count and chromatin structure in men exposed to inorganic lead: lowest adverse effect levels. Occup. Environ. Med., 2002, 59: 234–242.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    CHO K.J., YUN C.H., PACKER L., CHUNG A.S.: Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Ann. N. Y. Acad. Sci., 2001, 928: 141–156.

    PubMed  CAS  Article  Google Scholar 

  8. 8.

    CHRISTOPHE A., ZALATA A., MAHMOUD A., COMHAIRE F. Fatty acid composition of sperm phospholipids and its nutritional implications. Middle East Fert. Soc. J., 1998, 3: 46–53.

    Google Scholar 

  9. 9.

    CINTI D.L., COOK L., NAGI M.N., SUNEJA S.K.: The fatty acid chain elongation system of mammalian endoplasmic reticulum. Prog. Lipid Res., 1992, 31: 1–51.

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    COMHAIRE F.: Clinical andrology: from evidence-base to ethics. The ‘E’ quintet in clinical andrology. Hum. Reprod., 2000, 15: 2067–2071.

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    COMHAIRE F., VERMEULEN L.: Effect of high dose oral Kallikrein treatment in men with idiopathic subfertility: evaluation by means of in vitro penetration test of zona free hamster ova. Int. J. Androl., 1983, 6: 168–172.

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    COMHAIRE F.H., CHRISTOPHE A.B., ZALATA A.A., DHOOGE W.S., MAHMOUD A.M., DEPUYDT C.E.: The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile men. Prostaglandins Leukot. Essent. Fatty Acids, 2000, 63: 159–165.

    Article  CAS  Google Scholar 

  13. 13.

    COMHAIRE F.H., GAREM Y.F.E., MAHMOUD A., EERTMANS F., SCHOONJANS F.: Combined conventional/antioxidant “Astaxanthin” treatment for male infertility: a double blind randomized trial. Asian J. Androl., 2004, sous presse.

  14. 14.

    COMHAIRE F.H., MAHMOUD A.M.: Editorial commentary. J. Androl., 2004, 25: 771–772.

    Google Scholar 

  15. 15.

    COSTA M., CANALE D., FILICORI M., D’LDDIO S., LENZI A.: L-carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia, 1994, 26: 155–159.

    PubMed  CAS  Article  Google Scholar 

  16. 16.

    DAWSON E.B., HARRIS W.A., TETER M.C., POWELL L.C.: Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil. Steril., 1992, 58: 1034–1039.

    PubMed  CAS  Google Scholar 

  17. 17.

    DE ALOYSIO D., MANTUANO R., MAULONI M., NICOLETTI G.: The clinical use of arginine aspartate in male infertility. Acta Eur. Fertil., 1982, 13: 133–167.

    PubMed  Google Scholar 

  18. 18.

    DEBAUN M.R., NIEMITZ E.L., FEINBERG A.P.: Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am. J. Hum. Genet., 2003, 72: 156–160.

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    DEPUYDT C.E., MAHMOUD A.M., DHOOGE W.S., SCHOONJANS F.A., COMHAIRE F.H.: Hormonal regulation of inhibin B secretion by immature rat sertoli cells in vitro: possible use as a bioassay for estrogen detection. J. Androl., 1999, 20: 54–62.

    PubMed  CAS  Google Scholar 

  20. 20.

    EDWARDS R.G., LUDWIG M.: Are major defects in children conceived in vitro due to innate problems in patients or to induced genetic damage? Reprod. Biomed. Online, 2003, 7: 131–138.

    PubMed  Article  Google Scholar 

  21. 21.

    FRAGA C.G., MOTCHNIK P.A., SHIGENAGA M.K., HELBOCK H.J., JACOB R.A., AMES B.N.: Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc. Natl. Acad. Sci. U. S. A., 1991, 88: 11003–11006.

    PubMed  Article  CAS  Google Scholar 

  22. 22.

    GOLAN R., WEISSENBERG R., LEWIN L.M.: Carnitine and acetylcarnitine in motile and immotile human spermatozoa. Int. J. Androl., 1984, 7: 484–494.

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    GONZALES G.F., CORDOVA A., GONZALES C., CHUNG A., VEGA K., VILLENA A.: Lepidium meyenii (Maca) improved semen parameters in adult men. Asian J. Androl., 2001, 3: 301–303.

    PubMed  CAS  Google Scholar 

  24. 24.

    GONZALES G.F., RUIZ A., GONZALES C., VILLEGAS L., CORDOVA A.: Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats. Asian J. Androl., 2001, 3: 231–233.

    PubMed  CAS  Google Scholar 

  25. 25.

    GOTO S., KOGURE K., ABE K. et al.: Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochim. Biophys. Acta, 2001, 1512: 251–258.

    PubMed  Article  CAS  Google Scholar 

  26. 26.

    GREEN N.S.: Risks of birth defects and other adverse outcomes associated with assisted reproductive technology. Pediatrics, 2004, 114: 256–259.

    PubMed  Article  Google Scholar 

  27. 27.

    HANSEN M., KURINCZUK J.J., BOWER C., WEBB S.: The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N. Engl. J. Med., 2002, 346: 725–730.

    PubMed  Article  Google Scholar 

  28. 28.

    HUGHES C.M., LEWIS S.E., MCKELVEY-MARTIN V.J., THOMPSON W.: The effects of antioxidant supplementation during Percoll preparation on human sperm DNA integrity. Hum. Reprod., 1998, 13: 1240–1247.

    PubMed  Article  CAS  Google Scholar 

  29. 29.

    HURTADO DE CATALFO G.E., DE GOMEZ DUMM I.N.: Polyunsaturated fatty acid biosynthesis from [1–14C]20:3 n-6 acid in rat cultured Sertoli cells. Linoleic acid effect. Int. J. Biochem. Cell Biol., 2002, 34: 525–532.

    PubMed  Article  CAS  Google Scholar 

  30. 30.

    IRVINE D.S., TWIGG J.P., GORDON E.L., FULTON N., MILNE P.A., AITKEN R.J.: DNA integrity in human spermatozoa: relationships with semen quality. J. Androl., 2000, 21: 33–44.

    PubMed  CAS  Google Scholar 

  31. 31.

    IWAMOTO T., HOSODA K., HIRANO R. et al.: Inhibition of low-density lipoprotein oxidation by astaxanthin. J. Atheroscler. Thromb., 2000, 7: 216–222.

    PubMed  CAS  Google Scholar 

  32. 32.

    JEULIN C., LEWIN L.M. Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. Hum. Reprod. Update, 1996, 2: 87–102.

    PubMed  Article  CAS  Google Scholar 

  33. 33.

    KATZ P., NACHTIGALL R., SHOWSTACK J.: The economic impact of the assisted reproductive technologies. Nat. Cell Biol., 2002, 4 Suppl: s29-s32.

    PubMed  Article  Google Scholar 

  34. 34.

    KENT-FIRST M.G., KOL S., MUALLEM A. et al.: The incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers. Mol. Hum. Reprod., 1996, 2: 943–950.

    PubMed  Article  CAS  Google Scholar 

  35. 35.

    KESSOPOULOU E., POWERS H.J., SHARMA K.K. et al.: A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil. Steril., 1995, 64: 825–831.

    PubMed  CAS  Google Scholar 

  36. 36.

    KOHENGKUL S., TANPHAICHITR V., MUANGMUN V., TANPHAICHITR N.: Levels of L-carnitine and L-O-acetylcarnitine in normal and infertile human semen: a lower level of L-O-acetycarnitine in infertile semen. Fertil. Steril., 1977, 28: 1333–1336.

    PubMed  CAS  Google Scholar 

  37. 37.

    KOUDSTAAL J., BRUINSE H.W., HELMERHORST F.M., VERMEIDEN J.P., WILLEMSEN W.N., VISSER G.H. Obstetric outcome of twin pregnancies after in vitro fertilization: a matched control study in four Dutch University hospitals. Hum. Reprod., 2000, 15: 935–940.

    PubMed  Article  CAS  Google Scholar 

  38. 38.

    LAMBERT R.D.: Safety issues in assisted reproduction technology: the children of assisted reproduction confront the responsible conduct of assisted reproductive technologies. Hum. Reprod., 2002, 17: 3011–3015.

    PubMed  Article  Google Scholar 

  39. 39.

    LENZI A., CULASSO F., GANDINI L., LOMBARDO F., DONDERO F.: Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum. Reprod., 1993, 8: 1657–1662.

    PubMed  CAS  Google Scholar 

  40. 40.

    LENZI A., LOMBARDO F., SGRO P. et al.: Use of carnitine therapy in selected cases of male factor infertility: a doubleblind crossover trial. Fertil. Steril., 2003, 79: 292–300.

    PubMed  Article  Google Scholar 

  41. 41.

    LEWIN A., LAVON H.: The effect of coenzyme Q10 on sperm motility and function. Mol. Aspects Med., 1997, 18 Suppl: S213–9.

    Article  Google Scholar 

  42. 42.

    MA K., SHARKEY A., KIRSCH S. et al.: Towards the molecular localisation of the AZF locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome. Hum. Mol. Genet., 1992, 1: 29–33.

    PubMed  Article  CAS  Google Scholar 

  43. 43.

    MAHER E.R., AFNAN M., BARRATT C.L.: Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs? Hum. Reprod., 2003, 18: 2508–2511.

    PubMed  Article  Google Scholar 

  44. 44.

    MAHMOUD A., KISS P., KAUFMAN J.M., COMHAIRE F., ASCLEPIOS: The influence of age and lead exposure on inhibin B serum levels in men. Int. J. Androl., 2000, 23 (suppl. 1): PO94.

    Google Scholar 

  45. 45.

    MAHMOUD A.M., COMHAIRE F.H., DEPUYDT C.E.: The clinical and biological significance of serum inhibins in subfertile men. Reprod. Toxicol., 1998, 12: 591–599.

    PubMed  Article  CAS  Google Scholar 

  46. 46.

    MAYERHOFER A., MEINEKE V., KÖHN F.M., FRUNGIERI M.: Cyclooxygenase (COX-2) in male infertility: a new link between prostaglandins and testicular fibrosis? Andrologia, 2002, 34: 272–273.

    Google Scholar 

  47. 47.

    MEACHEM S.J., NIESCHLAG E., SIMONI M.: Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur. J. Endocrinol., 2001, 145: 561–571.

    PubMed  Article  CAS  Google Scholar 

  48. 48.

    MENCHINI-FABRIS G.F., CANALE D., IZZO P.L., OLIVIERI L., BARTELLONI M.: Free L-carnitine in human semen: its variability in different andrologic pathologies. Fertil. Steril., 1984, 42: 263–267.

    PubMed  CAS  Google Scholar 

  49. 49.

    MOLL A.C., IMHOF S.M., CRUYSBERG J.R., SCHOUTEN-VAN MEETEREN A.Y., BOERS M., VAN LEEUWEN F.E.: Incidence of retinoblastoma in children born after in vitro fertilisation. Lancet, 2003, 361: 309–310.

    PubMed  Article  Google Scholar 

  50. 50.

    MONCADA M.L., VICARI E., CIMINO C., CALOGERO A.E., MONGIOI A., D’AGATA R.: Effect of acetylcarnitine treatment in oligoasthenospermic patients. Acta Eur. Fertil., 1992, 23: 221–224.

    PubMed  CAS  Google Scholar 

  51. 51.

    PALERMO G., JORIS H., DEVROEY P., VAN STEIRTEGHEM A.C.: Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet, 1992, 340: 17–18.

    PubMed  Article  CAS  Google Scholar 

  52. 52.

    PINBORG A., LOFT A., SCHMIDT L., GREISEN G., RASMUSSEN S., ANDERSEN A.N.: Neurological sequelae in twins born after assisted conception: controlled national cohort study. Br. Med. J., 2004, 329: 311.

    Article  Google Scholar 

  53. 53.

    PRYOR J.P., BLANDY J.P., EVANS P., CHAPUT D.S.D., USHERWOOD M.: Controlled clinical trial of arginine for infertile men with oligozoospermia. Br. J. Urol., 1978, 50: 47–50.

    PubMed  Article  CAS  Google Scholar 

  54. 54.

    ROHDEWALD P.: A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int. J. Clin. Pharmacol. Ther., 2002, 40: 158–168.

    PubMed  CAS  Google Scholar 

  55. 55.

    ROLF C., COOPER T.G., YEUNG C.H., NIESCHLAG E.: Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, doubleblind study. Hum. Reprod., 1999, 14: 1028–1033.

    PubMed  Article  CAS  Google Scholar 

  56. 56.

    ROSEFF S.J., GULATI R.: Improvement of sperm quality by Pycnogenol. Eur. Bull. Drug Res., 1999, 7: 33–36.

    Google Scholar 

  57. 57.

    RUIZ-PESINI E., ALVAREZ E., ENRIQUEZ J.A., LOPEZ-PEREZ M.J.: Association between seminal plasma carnitine and sperm mitochondrial enzymatic activites. Int. J. Androl., 2001, 24: 335–340.

    PubMed  Article  CAS  Google Scholar 

  58. 58.

    SAETHER T., TRAN T.N., ROOTWELT H., CHRISTOPHERSEN B.O., HAUGEN T.B.: Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis. Biol. Reprod., 2003, 69: 117–124.

    PubMed  Article  CAS  Google Scholar 

  59. 59.

    SCHIEVE L.A., RASMUSSEN S.A., BUCK G.M., SCHENDEL D.E., REYNOLDS M.A., WRIGHT V.C.: Are children born after assisted reproductive technology at increased risk for adverse health outcomes? Obstet. Gynecol., 2004, 103: 1154–1163.

    PubMed  Google Scholar 

  60. 60.

    SCHILL W.B., KRIZIC A., RJOSK H.: Determination of various semen parameters and sex hormone levels in subfertile men during kallikrein therapy. Adv. Exp. Med. Biol., 1979, 120A: 537–546.

    PubMed  CAS  Google Scholar 

  61. 61.

    SCOTT R., MACPHERSON A., YATES R.W., HUSSAIN B., DIXON J.: The effect of oral selenium supplementation on human sperm motility. Br. J. Urol., 1998, 82: 76–80.

    PubMed  CAS  Google Scholar 

  62. 62.

    SHARPE R.M. The ‘oestrogen hypothesis’-where do we stand now? Int. J. Androl., 2003, 26: 2–15.

    PubMed  Article  CAS  Google Scholar 

  63. 63.

    SKAKKEBAEK N.E.: Testicular dysgenesis syndrome: new epidemiological evidence. Int. J. Androl., 2004, 27: 189–191.

    PubMed  Article  Google Scholar 

  64. 64.

    SOUFIR J.C., DUCOT B., MARSON J. et al.: Levels of seminal free L(−) carnitine in fertile and infertile men. Int. J. Androl., 1984, 7: 188–197.

    PubMed  Article  CAS  Google Scholar 

  65. 65.

    STEPTOE P.C., EDWARDS R.G.: Birth after the reimplantation of a human embryo. Lancet, 1978, 2: 366.

    PubMed  Article  CAS  Google Scholar 

  66. 66.

    STROMBERG B., DAHLQUIST G., ERICSON A., FINNSTROM O., KOSTER M., STJERNQVIST K.: Neurological sequelae in children born after in vitro fertilisation: a population-based study. Lancet, 2002, 359: 461–465.

    PubMed  Article  CAS  Google Scholar 

  67. 67.

    SUTCLIFFE A.G., TAYLOR B., LI J., THORNTON S., GRUDZINSKAS J.G., LIEBERMAN B.A.: Children born after intracytoplasmic sperm injection: population control study. Br. Med. J., 1999, 318: 704–705.

    CAS  Google Scholar 

  68. 68.

    TANPHAICHITR N.: In vitro stimulation of human sperm motility by acetylcarnitine. Int. J. Fertil., 1977, 22: 85–91.

    PubMed  CAS  Google Scholar 

  69. 69.

    TIEPOLO L., ZUFFARDI O.: Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum. Genet., 1976, 34: 119–124.

    PubMed  Article  CAS  Google Scholar 

  70. 70.

    TRAN T.N., RETTERSTOL K., CHRISTOPHERSEN B.O.: Metabolism of long-chain polyunsaturated fatty acids in testicular cells. In: De Vriese S.R., Christophe A.B. eds. Male fertility and lipid metabolism. Illinois, AOCS Press, 2003: 11–22.

    Google Scholar 

  71. 71.

    VAN DER VEN K., PESCHKA B., MONTAG M. et al.: Increased frequency of congenital chromosomal aberrations in female partners of couples undergoing intracytopiasmic sperm injection. Hum. Reprod., 1998, 13: 48–54.

    PubMed  Article  Google Scholar 

  72. 72.

    VAN DISSEL-EMILIANI F.M., GROOTENHUIS A.J., DE JONG F.H., DE ROOLJ D.G.: Inhibin reduces spermatogonial numbers in testes of adult mice and Chinese hamsters. Endocrinology, 1989, 125: 1899–1903.

    PubMed  Google Scholar 

  73. 73.

    VANHOORNE M., COMHAIRE F., DE BACQUER D.: Epidemiological study of the effects of carbon disulfide on male sexuality and reproduction. Arch. Environ. Health, 1994, 49: 273–278.

    PubMed  CAS  Article  Google Scholar 

  74. 74.

    VIRGILI F., KIM D., PACKER L.: Procyanidins extracted from pine bark protect alpha-tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite. FEBS Lett., 1998, 431: 315–318.

    PubMed  Article  CAS  Google Scholar 

  75. 75.

    VITALI G., PARENTE R., MELOTTI C.: Carnitine supplementation in human idiopathic asthenospermia: clinical results. Drugs Exp. Clin. Res., 1995, 21: 157–159.

    PubMed  CAS  Google Scholar 

  76. 76.

    VOLIANI S., BERTOZZI M.A., ROSSI P., MENCHINI-FABRIS G.F.: The treatment of male infertility with L-carnitine/L-acetyl carnitine. XVII National Congress, Societa Italiana Andrologia SIA, Venezia 2001, 2001, 8: 122.

    Google Scholar 

  77. 77.

    WANG C., MAKELA T., HASE T., ADLERCREUTZ H., KURZER M.S.: Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. J. Steroid Biochem. Mol. Biol., 1994, 50: 205–212.

    PubMed  Article  CAS  Google Scholar 

  78. 78.

    WENNERHOLM U., BERGH C., HAMBERGER L. et al.: Incidence of congenital malformations in children born after ICSI. Hum. Reprod., 2000, 15: 944–948.

    PubMed  Article  CAS  Google Scholar 

  79. 79.

    WILDMAN R.E.C., MEDEIROS D.M.: Advanced human nutrition. London, CRC Press, 2000: 370–371.

    Google Scholar 

  80. 80.

    WONG W.Y., MERKUS H.M., THOMAS C.M., MENKVELD R., ZIELHUIS G.A., STEEGERS-THEUNISSEN R.P.: Effects of folic acid and zinc sulfate on male factor subfertility: a doubleblind, randomized, placebo-controlled trial. Fertil. Steril., 2002, 77: 491–498.

    PubMed  Article  Google Scholar 

  81. 81.

    ZALATA A.A., CHRISTOPHE A.B., DEPUYDT C.E., SCHOONJANS F., COMHAIRE F.H.: The fatty acid composition of phospholipids of spermatozoa from infertile patients. Mol. Hum. Reprod., 1998, 4: 111–118.

    PubMed  Article  CAS  Google Scholar 

  82. 82.

    ZHENG B.L., HE K., KIM C.H. et al.: Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats. Urology, 2000, 55: 598–602.

    PubMed  Article  CAS  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Frank Comhaire.

Additional information

Communication au XXIo Congrès de la Société d’Andrologie de Langue Française, Clermont-Ferrand, 9–11 Décembre 2004.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Comhaire, F., Mahmoud, A. La nutraceutiques (alicaments) et compléments alimentaires dans le traitement de l’infertilité masculine. Androl. 15, 41–47 (2005).

Download citation

Mots clés

  • nutraceutiques
  • alicaments
  • infertilité
  • antioxydants
  • ADN oxydé
  • acides gras

Key words

  • nutraceuticals
  • infertility
  • fatty acids
  • antioxidants
  • astaxanthin