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  • Cancer du Testicule
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Cancer du testicule: BEP et spermatogenèse

Testicular tumours: BEP and spermatogenesis

Andrologie volume 12, pages 277–283 (2002)Cite this article

Resume

Les caractéristiques spermatiques de 44 hommes traités avec 2 cycles ou plus de chimiothérapie de type BEP pour des tumeurs testiculaires non séminomateuses ont été étudiées avant et 25.2 (± 19.4) mois après la fin de la chimiothérapie. La récupération des valeurs initiales de numération survenait plus fréquemment un an après la fin du traitement. Cette récupération était liée à la fonction testiculaire avant traitement et au temps écoulé depuis la fin de la chimiothérapie; dans la première année suivant la fin du traitement, cette récupération était fonction du nombre de cycles de BEP.

Notre étude est rassurante dans le long terme sur la toxicité du BEP sur la spermatogenèse. Toutefois, des études génétiques sont nécessaires concernant les effets possibles des traitements sur le matériel génétique spermatique durant cette phase de récupération.

Abstract

The sperm characteristics of 44 men treated with two or more courses of BEP chemotherapy for non seminomatous germ cell testicular tumours were investigated before and 25.2 ± 19.4 months after chemotherapy. Before treatment, 54.5% of patients were oligozoospermic. The mean sperm characteristics did not differ before and after chemotherapy. However, following chemotherapy, the recovery of initial sperm count was more frequent after one year than before. During the first year, recovery was more frequent in patients treated with two than in those treated with more than two BEP cycles. In patients with good pre-treatment sperm count, sperm production was reduced by half after chemotherapy. In a subgroup of men who provided two sperm samples after chemotherapy, sperm production was better in the second sample than in the first. Our data suggest that sperm recovery is related to testicular function prior to therapy, to the time elapsed after chemotherapy and in the first year to the number of chemotherapy cycles. In conclusion, our study is reassuring concerning the long-term male reproductive toxicity of BEP. However, further studies are required to analyse the possible effects on sperm genetic material during the recovery period.

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Authors and Affiliations

  1. Groupe de Recherche en Fertilité humaine, CECOS Midi-Pyrénées, Centre de Stérilité Masculine, Centre Hospitalier Universitaire La Grave, TSA 60033, 31059, Toulouse Cedex 9, France

    Myriam Daudin, Eric Huyghe & Louis Bujan

  2. Département d’Oncologie Médicale, Institut Claudius Regaud, Toulouse

    Christine Chevreau

  3. Service d’Urologie-Andrologie, CHU Rangueil, Toulouse

    Michel Soulié

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  1. Myriam Daudin
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  2. Eric Huyghe
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  3. Christine Chevreau
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  4. Michel Soulié
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  5. Louis Bujan
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Correspondence to Myriam Daudin.

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Daudin, M., Huyghe, E., Chevreau, C. et al. Cancer du testicule: BEP et spermatogenèse. Androl. 12, 277–283 (2002). https://doi.org/10.1007/BF03035140

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Basic and Clinical Andrology

ISSN: 2051-4190