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Andropause: Une histoire a suivre

Andropause: A story to be continued

Andrologievolume 1, Article number: 5 (1991) | Download Citation

Abstract

In males, the endocrine and exocrine functions of testes alterate with aging. Though in males, there is not a sudden and definitive interruption of reproduction function, as at menopause in females, spermatogenesis decreases, as testosterone production. This testicular decrease is escorted by a relative decrease of gonadotropin release. So, testicular function, vulnerable to aging, is to be continued.

Resume

Chez l’homme, les fonctions endocrine et exocrine du testicule s’altèrent avec l’âge. Bien qu’il n’y ait pas chez l’homme d’interruption brutale et définitive de la fonction de reproduction, comme à la ménopause chez la femme, la spermatogénèse diminue ainsi que la production de testosterone. Ce vieillissement testiculaire s’accompagne d’une défaillance relative de la secrétion de gonadotrophines. Ainsi, la fonction testiculaire, vulnérable avec l’âge est à suivre

References

  1. 1

    -Pugeat M, Tourniaire J: Le gonadostat de la femme ménopausée. In: “L’Equilibre Endocrinien et ses Ruptures” — Sandoz Edition 1979, p. 45–57

  2. 2

    -Seymour FI, Duffy C, Kœrner A: A case of authenticated fertility in a man of 94. J.A.M.A. 1935, 105; 1423.

  3. 3

    -Kinsey AC, Pomeroy WE, Martin CE, Gebhard PH: In “Sexual Behavior in the human male”, edited by WB Saunders, Philadelphia, 1948.

  4. 4

    -Vermeulen A, Rubens R, Verdonck L: Testosterone secretion and metabolism in male senescence. J. Clin. Endocrinol. Metab. 1972, 34: 730.

  5. 5

    -Rubens R, Dhont M, Vermeulen A: Further studies on Leydig cell function in old age. J. Clin. Endocrinol. Metab. 1974, 39: 40.

  6. 6

    -Pirke KM, Doerr P: Age related changes and interrelationships between plasma testosterone, oestradiol and testosteronebinding globulin in normal adult males. Acta Endocrinol. (Copenh) 1974, 74: 792.

  7. 7

    -Zumoff B, Strain GW, Kream J, O’Connor J, Rosenfeld RS, Levin J, Fukushima DK: Age variation of the 24-hour mean plasma concentrations of androgens, estrogens and gonadotropins in normal adult men. J. Clin. Endocrinol. Metab 1982, 54: 534.

  8. 8

    -Davidson JM, Chen JJ, Crapo L, Gray GD, Greeleaf WJ, Catania JA: Hormonal changes and sexual function in aging men. J. Clin. Endocrinol. Metab. 1983, 57: 71.

  9. 9

    -Deslypere JP, Vermeulen A: Leydig cell function in normal men: effect of age, life-style, residence, diet and activity. J. Clin. Endocrinol. Metab. 1984, 59: 955.

  10. 10

    -Tenover JS, Matsumoto AM, Plymate SR, Bremner WJ: The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J. Clin. Endocrinol. Metab. 1987, 65: 1118.

  11. 11

    -Déchaud H, Lejeune H, Garoscio-Cholet M, Mallein R, Pugeat M: Radioimmunoassay of testosterone not bound to sex-steroid-binding protein in plasma. Clin. Chem 1989, 35: 1609.

  12. 12

    -Bremner WJ, Vitiello MV, Prinz PN: Loss of circadian rythmicity in blood testosterone levels with aging in normal men. J. Clin. Endocrinol. Metab. 1983, 56: 1278.

  13. 13

    -Lewis JG, Ghanadian R, Chisholm GD: Serum 5α-Dihydrotestosterone and testosterone, changes with age in man. Acta Endocrinol. (Copenh) 1976, 82: 444.

  14. 14

    -Sparrow D, Boss R, Rowe JW: The influence of age, alcohol consumption, and body build on gonadal function in men. J. Clin. Endocrinol. Metab 1980, 51: 508.

  15. 15

    -Pirke KM, Doerr P: Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol. Acta Endocrinol. (Copenh) 1975, 80: 171.

  16. 16

    -Vermeulen A, Deslypere JP, Schelfhout W, Verdonck L, Rubens R: Adrenocortical function in old age: Response to acute adrenocorticotropin stimulation. J. Clin. Endocrinol. Metab. 1982, 54: 187.

  17. 17

    -Morimoto I, Edmiston A, Hawks D, Horton R: Studies on the origin of androstanediol and androstanedione glucuronide in young and elderly men. J. Clin. Endocrinol. Metab. 1981, 52: 772.

  18. 18

    -Roehrbom CG, Lange JL, George FW, Wilson JD. Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age. J. Clin. Invest. 1987, 79: 44.

  19. 19

    -Nankin MR, Lin T. Murono EP, Osterman J: The aging Leydig cell: III. Gonadotropin stimulation in men. J. Androl. 1981, 2: 181.

  20. 20

    -Neaves WB, Johnson L, Porter JC, Parker CR, Petty CS: Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J. Clin. Endocrinol. Metab. 1984, 59: 756.

  21. 21

    -Tenover JS, Dahl KD, Hsueh AJW, Lim P, Matsumoto AM, Bremner WJ: Serum bioactive and immunoreactive follicle-stimulating hormone levels and the response to clomiphene in healthy young and elderly men. J. Clin. Endocrinol. Metab. 1987, 64: 1103.

  22. 22

    -Tenover JS, McLachlan RI, Dahl KD, Burger HD, De Kretser DM, Bremner WJ: Decreased serum inhibin levels in normal elderly men: evidence for a decline in Sertoli cell function with aging. J. Clin. Endocrinol. Metab. 1988, 67: 455.

  23. 23

    -Johson L, Zane R, Petty CS, Neaves WB: Quantification of human Sertoli cell population: its distribution, relation to germ cell number, and agerelated decline. Biol. Reprod. 1984, 31: 785.

  24. 24

    -Takizawa T, Hatakeyama S: Age associated changes in microvasculature of human adult testis. Acta Path. Jap. 1978, 28: 541

  25. 25

    -Auroux M, Nawar NNY, Rizkalla N: Testicular aging: vascularization and gametogenesis modifications in the Wistar rat. Arch. Androl. 1985, 14: 115.

  26. 26

    -Pirke RM, Sintermann R, Vogt HJ: Testosterone and testosterone precursor in the spermatic vein and in the testicular tissue of old men. Reduced oxygen supply may explain the relative increase of progesterone and 17α-progesterone in the testicular tissue of old men. Gerontology 1980, 26: 221

  27. 27

    -Muta K, Kato K, Akamine Y, Ibayashi H: Agerelated changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol. (Copenh). 1981, 96: 154

  28. 28

    -Winters SJ, Sherins RJ, Troen P: The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolism 1984, 33: 1052.

  29. 29

    -Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A: Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J. Clin. Endocrinol. Metab. 1987, 64: 68.

  30. 30

    -Harman SM, Tsitouras PD, Costa PT, Blackman MR: Reproductive hormones in aging male. II Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone. J. Clin. Endocrinol. Metab. 1982, 54: 547.

  31. 31

    -Winters SJ, Troen P: Episodic luteinizing hormone (LH) secretion and the response of LH and folliclestimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. J. Clin. Endocrinol. Metab. 1982, 55: 560

  32. 32

    -Warner BA, Dufau ML, Santen RJ: Effets of aging and illness on the pituitary testicular axis in men: qualitative as well as quantitative changes in luteinizing hormone. J. Clin. Endocrinol. Metab 1985, 60: 263.

  33. 33

    -Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML: Attenuated release of biologically active luteinizing hormone in healthy aging men. J. Clin. Invest. 1988, 81: 1020.

  34. 34

    -Vermeulen A, Deslypere JP, Kaufman JM: Influence of antiopioids on luteinizing hormone pulsatility in aging men. J. Clin Endocrinol. Metab. 1989, 68: 68.

  35. 35

    -Lejeune H, Mockus I, Charrié A, Mazenod B, Pugeat M, Tourniaire J: Analyse de la pulsatilité de LH: importance de l’estimation des faux négatifs. Rev. Franç. Endocrinol. Clin. 1988, 29: 563.

  36. 36

    -Harman SM, Tsitouras PD: Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J. Clin. Endocrinol. Metab. 1980, 51: 35.

  37. 37

    -Nieschlag E, Lammers U, Freischem CW, Langer K, Wickings EJ: Reproductive functions in young fathers and grandfathers. J. Clin. Endocrinol. Metab. 1982, 55: 676.

  38. 38

    -Meikle AW, Stanish WM, Taylor N, Edwards C, Bishop DT: Familial effects on plasma sex-Steroid content in man: testosterone, estradiol and sex hormone-binding-globulin. Metabolism 1982, 31: 6.

  39. 39

    -Davidson JM, Carmago CA, Smith ER: Effects of androgen on sexual behavior in hypogonadal men. J. Clin. Endocrinol. Metab. 1979, 48: 955.

  40. 40

    -Kwan M, Greenleaf WJ, Mann J, Crapo L, Davidson JM: The nature of androgen action on male sexuality: a combined laboratory-self-report study on hypogonadal men. J. Clin. Endocrinol. Metab. 1983, 57: 557.

  41. 41

    -O’Carroll R, Shapiro C, Bancroft J: Androgens, behaviour and nocturnal erection in hypogonadal men: the effects of varying the replacement dose. Clin. Endocrinol. (Oxf) 1985, 23: 527.

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Author information

Affiliations

  1. Laboratoire de la Clinique Endocrinologique, Hôpital de l’Antiquaille, 69, Lyon

    • Michel Pugeat

  2. Laboratoire Central de Biochimie, Hôpital de l’Antiquaille, 69, Lyon

    • Henri Dechaud

  3. Hôpital Debrousse, Inserm U 307, 69, Lyon

    • Hervé Lejeune

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Corresponding author

Correspondence to Michel Pugeat.

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Key-words

  • Testosterone
  • Andropause

Mots clés

  • Testosterone
  • Andropause

Basic and Clinical Andrology

ISSN: 2051-4190