Skip to main content

Andropause: Une histoire a suivre

Andropause: A story to be continued

Abstract

In males, the endocrine and exocrine functions of testes alterate with aging. Though in males, there is not a sudden and definitive interruption of reproduction function, as at menopause in females, spermatogenesis decreases, as testosterone production. This testicular decrease is escorted by a relative decrease of gonadotropin release. So, testicular function, vulnerable to aging, is to be continued.

Resume

Chez l’homme, les fonctions endocrine et exocrine du testicule s’altèrent avec l’âge. Bien qu’il n’y ait pas chez l’homme d’interruption brutale et définitive de la fonction de reproduction, comme à la ménopause chez la femme, la spermatogénèse diminue ainsi que la production de testosterone. Ce vieillissement testiculaire s’accompagne d’une défaillance relative de la secrétion de gonadotrophines. Ainsi, la fonction testiculaire, vulnérable avec l’âge est à suivre

References

  1. 1

    -Pugeat M, Tourniaire J: Le gonadostat de la femme ménopausée. In: “L’Equilibre Endocrinien et ses Ruptures” — Sandoz Edition 1979, p. 45–57

  2. 2

    -Seymour FI, Duffy C, Kœrner A: A case of authenticated fertility in a man of 94. J.A.M.A. 1935, 105; 1423.

    Article  Google Scholar 

  3. 3

    -Kinsey AC, Pomeroy WE, Martin CE, Gebhard PH: In “Sexual Behavior in the human male”, edited by WB Saunders, Philadelphia, 1948.

    Google Scholar 

  4. 4

    -Vermeulen A, Rubens R, Verdonck L: Testosterone secretion and metabolism in male senescence. J. Clin. Endocrinol. Metab. 1972, 34: 730.

    CAS  Article  PubMed  Google Scholar 

  5. 5

    -Rubens R, Dhont M, Vermeulen A: Further studies on Leydig cell function in old age. J. Clin. Endocrinol. Metab. 1974, 39: 40.

    CAS  Article  PubMed  Google Scholar 

  6. 6

    -Pirke KM, Doerr P: Age related changes and interrelationships between plasma testosterone, oestradiol and testosteronebinding globulin in normal adult males. Acta Endocrinol. (Copenh) 1974, 74: 792.

    Google Scholar 

  7. 7

    -Zumoff B, Strain GW, Kream J, O’Connor J, Rosenfeld RS, Levin J, Fukushima DK: Age variation of the 24-hour mean plasma concentrations of androgens, estrogens and gonadotropins in normal adult men. J. Clin. Endocrinol. Metab 1982, 54: 534.

    CAS  Article  PubMed  Google Scholar 

  8. 8

    -Davidson JM, Chen JJ, Crapo L, Gray GD, Greeleaf WJ, Catania JA: Hormonal changes and sexual function in aging men. J. Clin. Endocrinol. Metab. 1983, 57: 71.

    CAS  Article  PubMed  Google Scholar 

  9. 9

    -Deslypere JP, Vermeulen A: Leydig cell function in normal men: effect of age, life-style, residence, diet and activity. J. Clin. Endocrinol. Metab. 1984, 59: 955.

    CAS  Article  PubMed  Google Scholar 

  10. 10

    -Tenover JS, Matsumoto AM, Plymate SR, Bremner WJ: The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J. Clin. Endocrinol. Metab. 1987, 65: 1118.

    CAS  Article  PubMed  Google Scholar 

  11. 11

    -Déchaud H, Lejeune H, Garoscio-Cholet M, Mallein R, Pugeat M: Radioimmunoassay of testosterone not bound to sex-steroid-binding protein in plasma. Clin. Chem 1989, 35: 1609.

    PubMed  Google Scholar 

  12. 12

    -Bremner WJ, Vitiello MV, Prinz PN: Loss of circadian rythmicity in blood testosterone levels with aging in normal men. J. Clin. Endocrinol. Metab. 1983, 56: 1278.

    CAS  Article  PubMed  Google Scholar 

  13. 13

    -Lewis JG, Ghanadian R, Chisholm GD: Serum 5α-Dihydrotestosterone and testosterone, changes with age in man. Acta Endocrinol. (Copenh) 1976, 82: 444.

    CAS  Google Scholar 

  14. 14

    -Sparrow D, Boss R, Rowe JW: The influence of age, alcohol consumption, and body build on gonadal function in men. J. Clin. Endocrinol. Metab 1980, 51: 508.

    CAS  Article  PubMed  Google Scholar 

  15. 15

    -Pirke KM, Doerr P: Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol. Acta Endocrinol. (Copenh) 1975, 80: 171.

    CAS  Google Scholar 

  16. 16

    -Vermeulen A, Deslypere JP, Schelfhout W, Verdonck L, Rubens R: Adrenocortical function in old age: Response to acute adrenocorticotropin stimulation. J. Clin. Endocrinol. Metab. 1982, 54: 187.

    CAS  Article  PubMed  Google Scholar 

  17. 17

    -Morimoto I, Edmiston A, Hawks D, Horton R: Studies on the origin of androstanediol and androstanedione glucuronide in young and elderly men. J. Clin. Endocrinol. Metab. 1981, 52: 772.

    CAS  Article  PubMed  Google Scholar 

  18. 18

    -Roehrbom CG, Lange JL, George FW, Wilson JD. Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age. J. Clin. Invest. 1987, 79: 44.

    Article  Google Scholar 

  19. 19

    -Nankin MR, Lin T. Murono EP, Osterman J: The aging Leydig cell: III. Gonadotropin stimulation in men. J. Androl. 1981, 2: 181.

    CAS  Article  Google Scholar 

  20. 20

    -Neaves WB, Johnson L, Porter JC, Parker CR, Petty CS: Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J. Clin. Endocrinol. Metab. 1984, 59: 756.

    CAS  Article  PubMed  Google Scholar 

  21. 21

    -Tenover JS, Dahl KD, Hsueh AJW, Lim P, Matsumoto AM, Bremner WJ: Serum bioactive and immunoreactive follicle-stimulating hormone levels and the response to clomiphene in healthy young and elderly men. J. Clin. Endocrinol. Metab. 1987, 64: 1103.

    CAS  Article  PubMed  Google Scholar 

  22. 22

    -Tenover JS, McLachlan RI, Dahl KD, Burger HD, De Kretser DM, Bremner WJ: Decreased serum inhibin levels in normal elderly men: evidence for a decline in Sertoli cell function with aging. J. Clin. Endocrinol. Metab. 1988, 67: 455.

    CAS  Article  PubMed  Google Scholar 

  23. 23

    -Johson L, Zane R, Petty CS, Neaves WB: Quantification of human Sertoli cell population: its distribution, relation to germ cell number, and agerelated decline. Biol. Reprod. 1984, 31: 785.

    Article  Google Scholar 

  24. 24

    -Takizawa T, Hatakeyama S: Age associated changes in microvasculature of human adult testis. Acta Path. Jap. 1978, 28: 541

    CAS  PubMed  Google Scholar 

  25. 25

    -Auroux M, Nawar NNY, Rizkalla N: Testicular aging: vascularization and gametogenesis modifications in the Wistar rat. Arch. Androl. 1985, 14: 115.

    CAS  Article  PubMed  Google Scholar 

  26. 26

    -Pirke RM, Sintermann R, Vogt HJ: Testosterone and testosterone precursor in the spermatic vein and in the testicular tissue of old men. Reduced oxygen supply may explain the relative increase of progesterone and 17α-progesterone in the testicular tissue of old men. Gerontology 1980, 26: 221

    CAS  Article  PubMed  Google Scholar 

  27. 27

    -Muta K, Kato K, Akamine Y, Ibayashi H: Agerelated changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol. (Copenh). 1981, 96: 154

    CAS  Google Scholar 

  28. 28

    -Winters SJ, Sherins RJ, Troen P: The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolism 1984, 33: 1052.

    CAS  Article  PubMed  Google Scholar 

  29. 29

    -Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A: Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J. Clin. Endocrinol. Metab. 1987, 64: 68.

    CAS  Article  PubMed  Google Scholar 

  30. 30

    -Harman SM, Tsitouras PD, Costa PT, Blackman MR: Reproductive hormones in aging male. II Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone. J. Clin. Endocrinol. Metab. 1982, 54: 547.

    CAS  Article  PubMed  Google Scholar 

  31. 31

    -Winters SJ, Troen P: Episodic luteinizing hormone (LH) secretion and the response of LH and folliclestimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. J. Clin. Endocrinol. Metab. 1982, 55: 560

    CAS  Article  PubMed  Google Scholar 

  32. 32

    -Warner BA, Dufau ML, Santen RJ: Effets of aging and illness on the pituitary testicular axis in men: qualitative as well as quantitative changes in luteinizing hormone. J. Clin. Endocrinol. Metab 1985, 60: 263.

    CAS  Article  PubMed  Google Scholar 

  33. 33

    -Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML: Attenuated release of biologically active luteinizing hormone in healthy aging men. J. Clin. Invest. 1988, 81: 1020.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  34. 34

    -Vermeulen A, Deslypere JP, Kaufman JM: Influence of antiopioids on luteinizing hormone pulsatility in aging men. J. Clin Endocrinol. Metab. 1989, 68: 68.

    CAS  Article  PubMed  Google Scholar 

  35. 35

    -Lejeune H, Mockus I, Charrié A, Mazenod B, Pugeat M, Tourniaire J: Analyse de la pulsatilité de LH: importance de l’estimation des faux négatifs. Rev. Franç. Endocrinol. Clin. 1988, 29: 563.

    Google Scholar 

  36. 36

    -Harman SM, Tsitouras PD: Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J. Clin. Endocrinol. Metab. 1980, 51: 35.

    CAS  Article  PubMed  Google Scholar 

  37. 37

    -Nieschlag E, Lammers U, Freischem CW, Langer K, Wickings EJ: Reproductive functions in young fathers and grandfathers. J. Clin. Endocrinol. Metab. 1982, 55: 676.

    CAS  Article  PubMed  Google Scholar 

  38. 38

    -Meikle AW, Stanish WM, Taylor N, Edwards C, Bishop DT: Familial effects on plasma sex-Steroid content in man: testosterone, estradiol and sex hormone-binding-globulin. Metabolism 1982, 31: 6.

    CAS  Article  PubMed  Google Scholar 

  39. 39

    -Davidson JM, Carmago CA, Smith ER: Effects of androgen on sexual behavior in hypogonadal men. J. Clin. Endocrinol. Metab. 1979, 48: 955.

    CAS  Article  PubMed  Google Scholar 

  40. 40

    -Kwan M, Greenleaf WJ, Mann J, Crapo L, Davidson JM: The nature of androgen action on male sexuality: a combined laboratory-self-report study on hypogonadal men. J. Clin. Endocrinol. Metab. 1983, 57: 557.

    CAS  Article  PubMed  Google Scholar 

  41. 41

    -O’Carroll R, Shapiro C, Bancroft J: Androgens, behaviour and nocturnal erection in hypogonadal men: the effects of varying the replacement dose. Clin. Endocrinol. (Oxf) 1985, 23: 527.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Michel Pugeat.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pugeat, M., Dechaud, H. & Lejeune, H. Andropause: Une histoire a suivre. Androl. 1, 5 (1991). https://doi.org/10.1007/BF03035075

Download citation

Key-words

  • Testosterone
  • Andropause

Mots clés

  • Testosterone
  • Andropause