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La part du mâle dans les avortements spontanés a répétition

Paternal age and habitual abortion

Resume

Les facteurs paternels, particulièrement génétiques, jouent un rôle dans les avortements spontanés à répétition (ASR). Le vieillissement paternel, dont on sait qu’il accroît le risque d’apparition de syndromes autosomiques dominants chez le conceptus, pourrait augmenter le risque d’ASR. Toutefois cette éventualité n’est pas clairement établie. Dans une perspective générale, le rôle d’un très jeune âge paternel devrait aussi être envisagé

Abstract

Paternal factors, particularly genetic ones, can play a role in habitual abortion (HA): trisomies, polyploidies and X monosomy are the most frequent forms of involved abnormalities. The male professionnal occupation is able to lead to HA through genetic defects. Paternal ageing, which increases the risk of autosomic dominant syndroms, could also increase the HA risk through more and more errors in spermatogonia DNA replication. However, this possibility is not clearly established. From a general point of view, the role of a very young paternal age should be also considered.

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Correspondence to M. Auroux.

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Auroux, M. La part du mâle dans les avortements spontanés a répétition. Androl. 6, 11–15 (1996). https://doi.org/10.1007/BF03035063

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Mots-clés

  • âge paternel
  • avortements spontanés à répétition
  • anomalies caryotypiques
  • mutations

Key words

  • paternal age
  • habitual abortion
  • caryotypical abnormalities
  • mutations