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Adeno-associated virus (AAV) in semen and testis: a role in infertility? An overview

Abstract

In the past decade, infection of the female genital tract with the ubiquitous adeno-associated viruses (AAV) has been reported by a number of authors. Though the virus is thought to be non-pathogenic, there were hints on an association of AAV with miscarriage and problems in pregnancy. In more recent years it has been discovered that there is also a rather frequent infection of male genital tissues supporting the hypothesis that this virus may be sexually transmitted and may play a role in infertility.

References

  1. BANTEL-SCHAAL U., ZUR HAUSEN H.: Characterization of the DNA of a defective human parvovirus isolated from a genital site. Virology, 1984, 134: 52–63.

    Article  PubMed  CAS  Google Scholar 

  2. BOTQUIN V., CID-ARREGUI A., SCHLEHOFER J.R.: Adenoassociated virus type 2 interferes with early development of mouse embryos. J. Gen. Virol., 1994, 75: 2655–2662.

    Article  PubMed  CAS  Google Scholar 

  3. BURGUETE T., RABREAU M., FONTANGES-DARRIET M., et al.: Evidence for infection of the human embryo with adeno-associated virus in pregnancy. Hum. Reprod., 1999, 14: 2396–2401.

    Article  PubMed  CAS  Google Scholar 

  4. DUPRESSOIR T., SCHLEHOFER J.R.: Infection naturelle à virus adéno-associé (AAV). Ann. Biol. Clin. (Paris), 1999, 57: 667–675.

    CAS  Google Scholar 

  5. ERLES K., ROHDE V., THAELE M., ROTH S., EDLER L., SCHLEHOFER J.R.: DNA of adeno-associated virus (AAV) in testicular tissue and in abnormal semen samples. Hum. Reprod., 2001, 16: 2333–2337.

    PubMed  CAS  Google Scholar 

  6. FLOTTE R.T., CARTER B.J.: Adeno-associated virus vectors for gene therapy. Gene Therapy, 1995, 2: 357–362.

    PubMed  CAS  Google Scholar 

  7. HAN L., PARMLEY T.H., KEITH S., KOZLOWSKI K.J., SMITH L.J., HERMONAT P.L.: High prevalence of adeno-associated virus (AAV) type 2 rep DNA in cervical materials: AAV may be sexually transmitted. Virus Genes, 1996, 12: 47–52.

    Article  PubMed  CAS  Google Scholar 

  8. KIEHL K., SCHLEHOFER J.R., SCHULTZ R., ZUGAIB M., ARMBRUSTER-MORAES E.: Adeno-associated virus DNA in human gestational trophoblastic disease. Placenta, 2002, 23: 4105–4110.

    Article  Google Scholar 

  9. KOTIN R.M., MENNINGER J.C., WARD D.C., BERNS K.I.: Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics, 1991, 10: 831–834.

    Article  PubMed  CAS  Google Scholar 

  10. MERLE L., ROHDE V., SCHLEHOFER J.R.: Evidence of chromosomal integration of AAV DNA in human testis tissue. Virus Genes, 2004, 28: 61–69.

    Article  Google Scholar 

  11. ROHDE V., ERLES K., SATTLER H.P., DEROUET H., WULLICH B., SCHLEHOFER J.R.: Detection of adeno-associated virus in human semen: does viral infection play a role in the pathogenesis of male infertility? Fertil. Steril., 1999, 72: 814–816.

    Article  PubMed  CAS  Google Scholar 

  12. SCHLEHOFER J.R.: The tumor suppressive properties of adeno-associated viruses. Mutat. Res., 1994, 305: 303–313.

    PubMed  CAS  Google Scholar 

  13. SCHLEHOFER J.R., DUPRESSOIR T.: Infectiology and pathology of human adeno-associated viruses. Contrib. Microbiol., 2000, 4: 59–67.

    Article  PubMed  CAS  Google Scholar 

  14. TOBIASCH E., RABREAU M., GELETNEKY K., et al.: Detection of adeno-associated virus DNA in human genital tissue and in material from spontaneous abortion. J. Med. Virol., 1994, 44: 215–222.

    Article  PubMed  CAS  Google Scholar 

  15. VENTUROLI S., CRICCA M., BONVICINI F., et al.: Detection of adeno-associated virus DNA in female genital samples by PCR-ELISA. J. Med. Virol., 2001, 64: 577–582.

    Article  PubMed  CAS  Google Scholar 

  16. WALZ C., DEPREZ A., DUPRESSOIR T., DURST M., RABREAU M., SCHLEHOFER J.R.: Interaction of human papillomavirus type 16 and adeno-associated virus type 2 coinfecting human cervical epithelium. J. Gen. Virol., 1997, 78: 1441–1452.

    PubMed  CAS  Google Scholar 

  17. WALZ C., ANISI T.R., SCHLEHOFER J.R., GISSMANN L., SCHNEIDER A., MULLER M.: Detection of infectious adenoassociated virus particles in human cervical biopsies. Virology, 1998, 247: 97–105.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Jörg R. Schlehofer.

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Schlehofer, J.R. Adeno-associated virus (AAV) in semen and testis: a role in infertility? An overview. Androl. 14, 317–319 (2004). https://doi.org/10.1007/BF03034919

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  • DOI: https://doi.org/10.1007/BF03034919

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