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  • Endocrinologie
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L'Inhibine B chez les blessés radiculo-médullaires. Résultats préliminaires

Inhibin B in spinal cord injured men. Preliminary results

Andrologie volume 9, pages 387–393 (1999)Cite this article

Résumé

Les lésions neurologiques constatées chez les hommes blessés radiculo-médullaires entraînent souvent une altération de la qualité du sperme et parfois une anéjaculation. Des biopsies testiculaires ont permis de mettre en évidence que l'atteinte médullaire peut être responsable de l'altération des cellules de la lignée germinale. Un bilan hormonal a été pratiqué chez 13 patients présentant une absence de sperme au moment de l'examen. Des dosages plasmatiques de testostérone totale et de testostérone biodisponible, de FSH et d'inhibine B ont été réalisés en comparaison avec des témoins du même âge sans problème apparent de reproduction. Des diminutions significatives des valeurs de testostérone totale, de testostérone biodisponible et d'inhibine B ont été mises en évidence chez les patients. Les valeurs de FSH en moyenne plus élevées chez les malades ne différent pas de manière significative de celles des témoins. Ces résultats permettent d'envisager que l'inhibine B pourrait être un bon marqueur de la fonction testiculaire et de la spermatogénèse. Une étude plus large et longitudinale devrait pouvoir répondre à cette question.

Abstract

Spinal cord injuries in adult men sometimes results in semen alteration and in ejaculation missing. Testicular biopsies showed spinal cord injury is bound with testicular and germinal cells alterations. An endocrine profile for thirteen patients without semen at the time of the study is performed: total testosterone, bioavailable testosterone, FSH and inhibin B. Compared with seven normal controls, subjects with spinal cord injury had a significantly lower value of total testosterone, bioavailable testosterone and inhibin B. The FSH values higher in spinal cord injury are not significative. These results allowed to expect inhibin B like a good marker of testicular function and spermatogenesis. A longitudinal and on more subjects will answer to this question.

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Authors and Affiliations

  1. Laboratoire d'Hormonologie, Service de Biochimie, Centre Hospitalier Lyon-Sud, Bat. B, 69495, Pierre-Bénite

    B. Mathian, A. Pallant, G. Pilonchéry & M. C. Patricot

  2. Hôpital de rééducation et de réadaptation fonctionnelle Henry Gabrielle, route de Vourles, 69230, Saint Genis Laval

    K. Charvier

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  1. B. Mathian
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  2. A. Pallant
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Mathian, B., Pallant, A., Pilonchéry, G. et al. L'Inhibine B chez les blessés radiculo-médullaires. Résultats préliminaires. Androl. 9, 387–393 (1999). https://doi.org/10.1007/BF03034812

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Basic and Clinical Andrology

ISSN: 2051-4190