- Maladies Sexuellement Transmissibles et Fertilité
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Infection génitale à chlamydia chez l’homme et retentissement sur la fécondité
Chlamydia genital infection in men repercution on fertility
Andrologie volume 4, pages 425–433 (1994)
Resume
Chlamydia trachomatis agent de la maladie sexuellement transmise la plus fréquente, est une bactérie dont le métabolisme intracellulaire particulier conditionne la persistance et l’évolution vers la chronicité et l’inflammation. L’infection chez l’homme a souvent été associée à une altération de la fécondité attribuée à des dégradations tissulaires, fonctionnelles et même immunologiques du tractus génital et des spermatozoïdes. La détection deChlamydia trachomatis dans le sperme, déjà difficile par les méthodes de culture cellulaire et d’immunofluorescence directe, devient possible grâce aux techniques d’amplification génique, et permet de déterminer une prévalence de l’infection dans le sperme à l’intérieur de 6 groupes de patients explorés en andrologie. La détermination des IgG sériques et des IgA séminales antiC. trachomatis associée a la PCR constitue un groupe de marqueurs devenus indispensables dans l’exploration de la pathologie génitale masculine et dans le bilan d’infertilité.
Abstract
Chlamydia trachomatis is responsible for the most common sexually transmitted disease, up to 40% of the non gonococcal urethritis. It is a compulsary intracellular parasite. Its peculiar metabolism makes the bacteria interfere with the host cell immunity. Infection can become chronic and induce inflammation, if not properly treated, by permanent emission of antigens and heat shock proteins, and stimulation of Tcells. Autoimmunization against sperm can occur and impair fertilization and embryo implantation. Thus, Chlamydial infection can be associated with male infertility because of tissue damage, altered movement and antisperm immunization. PCR and LCR are to date the most sensitive detection techniques for c.trachomatis. Our study aim was to determine the prevalence of Chlamydial infection by PCR in 6 groups of men in andrologic practice. The highest prevalences have been found in the infertile men group and in the symptomatic group. No Chlamydia culture was found positive in any group. The association of PCR with anti C. trachomatis seminal IgA and seric IgG are useful tools for andrologic exploration.
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Askienazy-Elbhar, M., Dolivo, M., Izard, V. et al. Infection génitale à chlamydia chez l’homme et retentissement sur la fécondité. Androl. 4, 425–433 (1994). https://doi.org/10.1007/BF03034726
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DOI: https://doi.org/10.1007/BF03034726