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Germes à tropisme cellulaire (Chlamydiae, Mycoplasmes) et perturbation de la fécondance du sperme

Intracellular infections (Chlamydiæ, Mycoplasmas) modifications in sperm Fertility

Resume

De nombreux facteurs peuvent constituer un risque pour la fertilité chez l’homme. Parmi ceux-ci, les infections du sperme sont fréquemment citées, et plus particulièrement les infections du sperme à chlamydia et celles à mycoplasmes. Nous avons revu les principaux résultats rapportés dans la littérature concernant les infections à mycoplasmes et à chlamydia, et essayé de dégager leurs effets potentiels sur la fécondance du sperme. Pour chacun de ces deux agents infectieux, seront successivement envisagés, les effets sur les paramètres du sperme, sur le taux de fécondation, et sur le développement de l’embryon.

Abstract

Many factors are liable to be risk factors for fertility in the human male. Among these factors, semen infections are frequently quoted, and more specially semen infections with chlamydia trachomatis and those with mycoplasma. In this review of the literature, the author focused on the potential effects of such chlamydia or mycoplasma infections upon the fertilization ability of spermatozoa, as assessed through semen parameters, fertilization rate

References

  1. 1.

    Styler M, Shapiro S.S.: Mollicutes (mycoplasma) in infertility. Fertil. Steril. 1985; 44: 1–12.

    PubMed  CAS  Google Scholar 

  2. 2.

    Gnarpe H., Friberg J.: T-Mycoplasma as a possible cause for reproductive failure. Nature. 1973, 245: 97.

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    De Louvois J., Blades M., Harrisson R.F., Hurley R., Stanley V.C.: Frequency of mycoplasma in fertile and infertile couples. Lancet 1974; 1: 1083.

    Google Scholar 

  4. 4.

    Isus F.: Approche thérapeutique de l’infection du sperme dans l’infertilité masculine. Thèse Médecine. 1993-93-TOU3-100.

  5. 5.

    Matthews C.D. Elmslie R.G., Clapp K.H., Svigos J.M.: The frequency of genital mycoplasma infection in human infertility. Fertil. Steril. 1975; 26: 988–990.

    PubMed  CAS  Google Scholar 

  6. 6.

    Gump D.W., Gibson M.G., Ashikaya T.: Lack of association between genital mycoplasmas and infertility. N. Engl. J. Med. 1984; 310: 937–938.

    PubMed  CAS  Google Scholar 

  7. 7.

    Mathieu D, Jacques L., Auer J., Auroux M.: Hyperfertilité, spermoculture positive et paramètres du sperme. Nouv. Dermatol. 1988; 7 suppl. 2; 240–244.

    Google Scholar 

  8. 8.

    Fowkles D.M., Dooher G.B., O’Leary W.M.: Evidence by scanning electron microscopy for an association between spermatozoa and T-mycoplasma in men of infertile marriage. Fertil. Steril. 1975; 26: 1203–1211.

    Google Scholar 

  9. 9.

    Fowlkes D.M., Macleod J., O’Leary W.N. T-mycoplasma and human infertility: correlation of infection with alterations in seminal parameters. Fertil. Steril. 1975, 26: 1212–1218.

    PubMed  CAS  Google Scholar 

  10. 10.

    Upadhyaya M., Hibbard B.M., Walker S.M.: The effect of ureaplasma urealyticum on semen characteristics. Fertil. Steril. 1984; 41: 304–308.

    PubMed  CAS  Google Scholar 

  11. 11.

    Naessens A., Foulon W. Debrucker P., Dewoey P., Lauwers S.: Recovery of micro-organisms in semen and relationship to semen evaluation. Fertil. Steril. 1986; 45: 101–105.

    PubMed  CAS  Google Scholar 

  12. 12.

    Cintron R.D., Wortham J.W.E., Acosta A.: The association of semen factors with the recovery of Ureaplasma Urealyticum. Fertil. Steril. 1981; 36: 648–652.

    PubMed  CAS  Google Scholar 

  13. 13.

    Wolff H., Neubert U., Zebhauser M., Bezolol G., Korting H.C., Meurer M.: Chlamydia trachomatis induces an inflammatory response in the male genital tract and is associated with altered semen quality. Fertil. Steril. 1991; 55: 1017–1019.

    PubMed  CAS  Google Scholar 

  14. 14.

    Hill C.A., Tucker M.J., Whittingham D.G., Craft L.: Mycoplasma and in vitro fertilization. Fertil. Steril. 1987; 47: 652–655.

    PubMed  CAS  Google Scholar 

  15. 15.

    Montagut J.M., Lepretre S., Degoy J., Rousseau M.: Ureaplasma in semen and IVF. Hum. Reprod. 1991; 6: 727–729.

    PubMed  CAS  Google Scholar 

  16. 16.

    Swenson C.E., Toth A., O’leary W.M.: Ureaplasma urealyticum and human infertility: the effect of antibiotic therapy on semen quality. Fertil. Steril. 1979; 31: 660–665.

    PubMed  CAS  Google Scholar 

  17. 17.

    Cortesse A., Auroux M., Jacques L., Auer J., Feneux D., Leduc A.: Anomalie de la mobilité des spermatozoïdes après infection du sperme humain in vitro. Role d’Ureaplasma urealyticum. Presse Med. 1987; 16: 1375–1376.

    PubMed  CAS  Google Scholar 

  18. 18.

    Toth A., Lesser M.L.: Ureaplasma urealyticum and infertility. A-The effect of different antibiotics regimens on semen quality. B-Two year follow-up on pregnancy rate after antibiotic therapy. In: Les Colloques de I’INSERM. Facteurs de la fertilité humaine. A. Spira, P. Jouannet, Ed., INSERM, 1981, vol. 103; 509–514.

  19. 19.

    Talkingkton D.F., David J.K. et al.: The effects of three serotypes of Ureaplasma Urealyticum on spermatozoal motility and penetration in vitro. Fertil. Steril. 1991; 55: 170–176.

    Google Scholar 

  20. 20.

    Rose B.L., Scott B.: Sperm motility, morphology, hyperactivation and ionophore induced acrosome reactions after overnight incubation with mycoplasmas. Fertil. Steril. 1994; 61: 341–348.

    PubMed  CAS  Google Scholar 

  21. 21.

    Busolo F., Zanchetta R., Bertolini G.: Mycoplasmic localization patterns on spermatozoa from infertile men. Fertil. Steril. 1984; 42: 412–417.

    PubMed  CAS  Google Scholar 

  22. 22.

    Harrison R.F., Blades M., De Louvois J., Hurley R.: Doxycline treatment and human infertility. Lancet 1975; 1: 605–607.

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Busolo F, Zanchetta R. The effect of Mycoplasma hominis and Ureaplasma urealyticum on hamster egg in vitro penetration by human spermatozoa. Fertil. Steril. 1985, 43: 110–114.

    PubMed  CAS  Google Scholar 

  24. 24.

    Friberg J. Mycoplasmas and ureaplasmas in infertility and abortion. Fertil. Steril. 1980, 33: 351.

    PubMed  CAS  Google Scholar 

  25. 25.

    Auroux M., Jacques L., Mathieu D., Auer J.: Is the sperm bacterial ratio a determining factor in impairment of sperm motility: an in-vitro study in man with Escherichia Coli. Int. J. Androl. 1991, 23: 387–394.

    Google Scholar 

  26. 26.

    Pearlman M.D., Mc Neeley S.G.: A view of the microbiology, immunology and clinical implications of Chlamydia trachomatis infections. Obstet. Gynecol. Surv. 1992; 47: 448–461.

    PubMed  Article  CAS  Google Scholar 

  27. 27.

    Mardh P.A., Colleen S., Sylwan J.: Inhibitory effect on the formation of chlamydial inclusions in McCoy cells by seminal fluid and some of its components. Invest. Urol. 1980; 17: 510–515.

    PubMed  CAS  Google Scholar 

  28. 28.

    Wolner-Hanssen P., Mardh P.A.: In vitro test of adherence of chlamydia trachomatis to human spermatozoa. Fertil. Steril. 1984; 42: 102–107.

    PubMed  CAS  Google Scholar 

  29. 29.

    Sherman J.K., Jordan G.W.: Cryosurvival of chlamydia trachomatis during cryoperservation of human spermatozoa. Fertil. Steril. 1985; 43: 664–666.

    PubMed  CAS  Google Scholar 

  30. 30.

    Thorsen P., Moller B.R., Halkier-Sorensen L., From E., Nielsen N.C.: Survival of chlamydiae in human semen prepared for artificial insemination by donor. Acta Obstet. Gynecol. Scand. 1991; 70: 133–135.

    PubMed  Article  CAS  Google Scholar 

  31. 31.

    Leiva J.L., Peterson E.M., Wetkowski M., De la Mzza P., Stone C.C.: Micro-organisms in semen used for artificial insemination. Obstet. Gynecol. 1985; 65: 669–672.

    PubMed  CAS  Google Scholar 

  32. 32.

    Nagel T.C., Tagatz G.E., Campbell B.F.: Transmission of chlamydia trachomatis by artificial insemination. Fertil. Steril. 1986; 46: 959–960.

    PubMed  CAS  Google Scholar 

  33. 33.

    Van den Brule A.J.C., Hemrika D.J., Walboomers J.M.M., Raaphorst P., Van Amstel N., Bleker O.P., Meijer C.J.L.M.: Detection of chlamydia trachomatis in semen of artificial insemination donors by the polymerase chain reaction. Fertil. Steril. 1993; 59: 1098–1104.

    PubMed  Google Scholar 

  34. 34.

    Bjercke S. &Purvis K.: Chlamydial serology in the investigation of infertility. Hum. Reprod. 1992; 7: 621–624.

    PubMed  CAS  Google Scholar 

  35. 35.

    Diquelon J.Y., Partorini P., Feneux D., Gicquel J.M.: Le role de chlamydia trachomatis dans la survenue de mouvements anormaux des spermatozoïdes. J. Gynecol. Obst. Biol. Reprod. 1989; 18: 615–625.

    Google Scholar 

  36. 36.

    Witkin S.S., Jeremias J., Grifo J.A., Ledger W.J.: Detection of chlamidia trachomatis in semen by the polymerase chain reaction in male members of infertile couples. Am. J. Obstet. Gynecol. 1993; 168: 1457–1462.

    PubMed  CAS  Google Scholar 

  37. 37.

    Hellstrom W.J.G., Schachter J., Sweet R.L., Dale McClure R.: Is there a role for chlamydia trachomatis and genital mycoplasma in male infertility. Fertil. Steril. 1987, 48, 2: 337–339.

    PubMed  CAS  Google Scholar 

  38. 38.

    Close C.E., Wang S.P., Roberts P.L., Berger R.E.: The relationship of infection with chlamydia trachomatis to the parameters of male fertility and sperm auto-immunity. Fertil. Steril. 1987; 48: 880–883.

    PubMed  CAS  Google Scholar 

  39. 39.

    Toth A., Lesser M.L.: Asymptompatic bacteria in fertile and infertile men. Fertil. Steril. 1981; 36: 88–91.

    PubMed  CAS  Google Scholar 

  40. 40.

    Witkin S.S., Toth A.: Relationship between genital tract infection, sperm antibodies in seminal fluid and infertility. Fertil. Steril. 1983; 40: 805–808.

    PubMed  CAS  Google Scholar 

  41. 41.

    Jacques L., Mathieu D., Auer J., Auroux M.: Effect of urogeniral infections on sperm parameten and hypofertility in man. Biomed. & Pharmacother 1990; 44, 225–228.

    Article  CAS  Google Scholar 

  42. 42.

    Eggest-Kruse W., Pohl S., Naher H., Tilgen W., Ruunebaum B.: Microbial colonization and sperm mucus interaction: results in 1000 infertile couples. Hum. Reprod. 1992; 5: 612–620.

    Google Scholar 

  43. 43.

    Auroux M.R., De Mouy D.M., Acar J.F. Male fertility and positive chlamydia trachomatis. A study of 61 fertile and 82 subfertile men. J. Androl. 1987, 8: 197–200.

    PubMed  CAS  Google Scholar 

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Correspondence to Roger Mieusset.

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Mieusset, R. Germes à tropisme cellulaire (Chlamydiae, Mycoplasmes) et perturbation de la fécondance du sperme. Androl. 4, 406–413 (1994). https://doi.org/10.1007/BF03034723

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Mots-clés

  • Mycoplasmes
  • Chlamydiae
  • Spermatozoïdes
  • Fertilité and embryonic development

Key words

  • Mycoplasmas
  • Chlamydiae
  • Spermatozoa
  • Fecundity