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Physiologie de l’interaction gametique: Revue de la litterature

Physiology of gamete inter-action: A review

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Our knowledge of gamete interaction in vitro and in vivo has grown rapidly over the last century. Its importance has been reinforced by the development of in vitro fertilization and assisted conception procedures on one hand, and by research on the development of contraceptive vaccines on the other. This literature review synthesizes our current understanding of the successive steps in the fertilization process from sperm capacitation allthrough gamete fusion, including sperm interaction with the cumulus oophorus and the zona pellucida, as well as consideration on the mechanisms and timing of the acrosome reaction.


L’interaction gamétique, in vitro comme in vivo, est un domaine ou l’acquisition des connaissances a été très rapide au cours de ce siècle. Son importance s’est encore renforcée avec le développement de la fécondation in vitro et la fécondation assistée d’une part, et des recherches de vaccins contraceptifs d’autre part. La revue de la littérature présentée ici fait le point sur les différentes étapes de ce phénomène, de la capacitation du spermatozoïde à la fusion gamétique en passant par l’interaction du spermatozoïde avec le cumulus oophurus et la zone pellucide et par les mécanismes et la chronologie de la réaction acrosomique.


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Englert, Y., Bertrand, E. Physiologie de l’interaction gametique: Revue de la litterature. Androl. 2, 92–96 (1992).

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  • Fertilization
  • capacitation
  • acrosome reaction
  • zona pellucida
  • gamete fusion

Mots clés

  • Fertilisation
  • capacitation
  • réaction acrosomique
  • zone pellucide
  • fusion gamétique