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Régulation paracrine des fonctions leydigiennes

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  1. 1.

    Aoki A, Fawcett DW. Is there a local feedback from seminiferous tubules affecting activity of the Leydig cell? Biol. Reprod., 1978, 19: 144–158.

  2. 2.

    Avallet O, Vigier M, Perrard-Sapori MH, Saez JM. Transforming growth factor β inhibits Leydig cell functions. Biochem. Biophys. Res. Commun., 1987, 146: 575–581.

  3. 3.

    Avallet O, Vigier M, Chatelain PG, Saez JM. Regulation by growth factors of Leydig cell differentiated functions. J. Steroid Biochem. Molec. Biol., 1991, 40: 453–64.

  4. 4.

    Bergh A. Local differences in Leydig cell morphology in the adult rat testis: evidence for a local control of Leydig cells by adjacent seminiferous tubules. Int. J. Androl., 1982, 5: 325–330.

  5. 5.

    Bernier M, Chatelain P, Mather JP, Saez JM. Regulation of gonadotropin receptor, gonadotropin responsiveness and cell multiplication by somatomedin-C and insulin in cultured pig Leydig cells. J. Cell. Physiol., 1986, 129: 257–263.

  6. 6.

    Chatelain PG, Sanchez P, Saez JM. Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf mice. Endocrinology, 1991, 128: 1857–1862.

  7. 7.

    Chen YDI, Shaw MJ, Payne AH. Steroid and FSH action on LH receptors and LH-sensitive testicular responsiveness during sexual maturation of the rat. Mol. Cell. Endocr., 1977, 8: 291–299.

  8. 8.

    Cooke BA, Golding M, Dix CJ, Hunter MG. Catecholamine stimulation of testosterone production via cyclic AMP in mous Leydig cells in monolayer culture. Mol. Cell. Endocrinol., 1982, 27: 221–231.

  9. 9.

    Hsueh AJW, Dahl KD, Vaughan J, Tucker E, Rivier J, Bardin CW, Vale W. Heterodimers and homodimers of inhibin have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc. Natl. Acad. Sci. USA., 1987, 84: 5082–5086.

  10. 10.

    Johnson BH, Ewing LL. Follicle-stimulationg hormone and the regulation of testosterone secretion in the rabbit testis. Science, 1971, 173: 635–637.

  11. 11.

    Kerr JB, Sharpe RM. Follicle-stimulating hormone induction of leydig cell maturation. Endocrinology, 1985, 116: 2592–2604.

  12. 12.

    Kasson BG, Adashi EY, Hsueh AJW. Argininevasopressin in the testis: an intragonadal peptide control system. Endocrine Rev., 1985, 7: 156–168.

  13. 13.

    Khanum A, Dufau ML. Angiotensin II receptors and inhibitory actions in Leydig cells. J. Biol. Chem., 1988, 263: 5070–5074.

  14. 14.

    Kulin HE, Samoslik E, Santen R, Santner S. The effect of growth hormone on the leydig cell response to chorionic gonadotropin in boys with hypopituitarism. Clin. Endocrinol., 1981; 15: 462–472.

  15. 15.

    Lejeune H, Skalli M, Sanchez P, Avallet O, Saez JM. (1993). Enhancement of testosterone secretion by normal adult human Leydig cells by co-culture with enriched preparations of normal adult human Sertoli cells. Int. J. Androl., 1993, 16: 27–34.

  16. 16.

    Moger WH, Murphy PR. Reevaluation of the effect of follicle-stimulating hormone on the steroidogenic capacity of the testis: the effects of neuraminidase-treated FSH preparations. Biol. Reprod., 1982, 26: 422–428.

  17. 17.

    Odell WD, Swerdloff RS. Etiologies of sexual maturation: a model system based on the sexually maturing rat. Rec. Prog. Hornl. Res., 1967 32:245–288.

  18. 18.

    Parvinen M, Nikula H, Huhtaniemi I. Influence of rat seminiferous tubules on Leydig cell testostérone production in vitro. Mol. Cell. Endocrinol., 1984, 37: 331–336.

  19. 19.

    Perrard-Sapori MH, Chatelain PG, Rogemond N, Saez JM. Modulation of Leydig cell functions by culture with Sertoli cells of with Sertoli cell conditioned medium: Effects of insulin, somato-medin-C and FSH. Mol. Cell. Endocrinol., 1987, 50: 193–201.

  20. 20.

    Perrard-Sapori MH, Chatelain PG, Jaillard C, Saez JM. Characterization gulation of somatomedin-C/Insulin-like growth factor 1 (Sm-C) receptors on cultured pig Leydig cells. Eur. J. Biochem., 1987, 165: 209–214.

  21. 21.

    Risbridger GP, Kerr JB, Peake RA, De Kretser DM. Assessement of Leydig cell function after bilateral or unilateral efferent duct ligation: further evidence for a local control of Leydig cell function. Endocrinology, 1981, 108: 1234–1241.

  22. 22.

    Saez JM, Avallet O, Naville D, Perrard-Sapori MH, Chatelain PG. Sertoli-Leydig cell communications. Ann. N. Y. Acad. Sci., 1989, 564: 210–231.

  23. 23.

    Sharpe RM. Local control of testicular function. QJ1. Exp. Physiol., 1983, 68: 265–282.

  24. 24.

    Sharpe RM. Intratesticular factors controlling testicular function. Biol. Reprod., 1984, 30: 29–49.

  25. 25.

    Sizonenko PC, Cuendet A, Paunier L. FSH. I. Evidence for its mediating role on testosterone secretion in cryptorchidism. J. Clin. Endocrinol. Metab., 1973, 37: 68–73.

  26. 26.

    Tanner JM, Whitehouse RH. A note on the bone age at which patients with true isolated growth hormone deiciency enter puberty. J. Clin. Endocrinol. Metab., 1975, 41: 788–790.

  27. 27.

    Tabone E, Benhamed M, Reventos J, Saez JM. Interaction between immature porcine Leydig and Sertoli cells in vitro. Ultrastructural and biochemical study. Cell. Tiss. Res., 1984, 237: 357–362.

  28. 28.

    Tsatsoulis A, Whithead E, St. John J, Shalet SM, Robertson WR. The pituitary-Leydig cell axis in men with severe damage to the germinal epithelium. Clin. Endocrinol., 1987, 27: 683–689.

  29. 29.

    Ulisse S, Fabbri A, Dufau ML. Corticotropin-releasing factor receptors and actions in rat Leydig cells. J. Biol. Chem., 1989, 264: 2156–2163.

  30. 30.

    Van Beurden WMO, Roodnat B, De Jong LH, Van Der Molen HJ. Hormonal regulation of LH stimulation of testosterone production in isolated Leydig cells of immature rats: the effect of hypophysectomy, FSH and estradiol-17b. Steroids, 1976, 28: 247–259.

  31. 31.

    Verhoeven G, Cailleau J. Stimulatory effects of epidermal growth factor on steroidogenesis in Leydig cells. Mol. Cell. Endrcinol., 1986, 47: 57–68.

  32. 32.

    Verhoeven G, Cailleau J, Van Damme J, Billiau A. Interleukin-1 stimulates steroidogenesis in cultured rat Leydig cells. Mol. Cell. Endocrinol., 1988, 57: 51–60.

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Correspondence to Hervé Lejeune.

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Lejeune, H., Saez, J.M. Régulation paracrine des fonctions leydigiennes. Androl. 3, 16 (1993) doi:10.1007/BF03034604

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