Skip to main content

Advertisement

Regulation de la secretion androgenique du testitule

Regulation of testicular androgen secretion

Article metrics

Abstract

Although LH undoubtedly remains the major factor controlling testicular androgen production, there is increasing evidence for the existence of a complex network of paracrine and autocrine intratesticular factors capable of modulating the development, differenciation and activity of the Leydig cells. This review summarizes the present understanding of intratesticular factors affecting Leydig cell function. Attention has been focussed upon the identification of tubular agonist which might mediate the effects of FSH on the production of androgens by Leydig cells. The findings discussed illustrate that even for such a welldefined function there are many candidates, and that the major agonists remain to be characterized. Moreover, all our present knowledge is based on invitro data, and the in-vivo role of all these agonists remains to be evaluated.

Resume

Bien que la LH reste le principal facteur responsable de la rulation de la sécrétion androgénique du testicule, le développement, la différentiation et l’activité des cellules de Leydig sont également modulés par toute une série de facteurs intratesticulaires. Dans cet article nous avons tenté de donner un aperçu de ce contrôle local (régulations paracrines et/ou endocrines) de la fonction des cellules de Leydig. Nos recherches ont porté sur l’identification de facteurs tubulaires qui pourraient moduler les effets de la FSH sur la production des androgènes. Les données présentées montrent l’existence de nombreux candidats à cette fonction. La plupart de ces molécules agonistes doivent encore être caractérisées. De plus leur rôle exact reste à être évalué in vivo.

References

  1. 1

    -Benahmed M, Grenot C, Tabone E, Sanchez P, Morera AM: FSH regulates cultured Leydig cell function via Sertoli cell proteins: an in vitro study. Biochem. Biophys. Res. Comm., 1985, 132:729.

  2. 2

    -Bergh A: Paracrine regulation of Leydig cells by the seminiferous tubules. Int. J. Androl., 1983, 6:57.

  3. 3

    -Cailleau J, Vermeire S, Verhoeven G: Independent control of the production of insulinlike growth factor I and its binding protein by cultured testicular cells. Mol. Cell. Endocrinol., 1990, 69:79.

  4. 4

    -Cooke BA: Is cyclic AMP an obligatory second messenger for luteinizing hormone? Mol. Cell. Endocrinol., 1990, 69:C11.

  5. 5

    -de Kretser DM.: Sertoli cell-Leydig cell interaction in the regulation of testicular function. Int. J. Androl., 1982, Supplement ~ 5:11.

  6. 6

    -Dombrowicz D.: Contrôle hypophysaire du développement testiculaire chez le rat: aspects biochimiques et histologiques. Thèse de doctorat, 1991, Liège, Belgium.

  7. 7

    -Dufau ML.: Endocrine regulation and communicating functions of the Leydig cell. Ann. Rev. Physiol., 1988, 50:483.

  8. 8

    -Hardy MP, Zirkin BR, Ewing LL: Kinetic studies on the development of the adult population of Leydig cells in testes of the pubertal rat. Endocrinology, 1989, 124:762.

  9. 9

    -Hedger MP, Robertson DM, de Kretser DM, Risbridger GP.: The quantification of steroidogenesis-stimulating activity in testicular interstitial fluid by an in vitro bioassay employing adult rat Leydig cells. Endocrinology., 1990, 127:1967.

  10. 10

    -Kerr JB.: The fate of fetal Leydig cells in the developing rat testis. Serono Symposia Publications, 1988, 50:175.

  11. 11

    -Manasco PK, Girton ME, Diggs RL, Doppman JL, Feuillan PP, Barnes KM, Cutler GB, Loriaux DL, Albertson BD.: A novel testis-stimulating factor in familial male precocious puberty. J. Engl. J. Med., 1991, 324:227.

  12. 12

    -Mc Farland KC, Sprengel R, Phillips HS, Kohler M, Rosulblit N, Nikolics K, Segaloff DL, Seeburg P.: Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science, 1989, 245:494.

  13. 13

    -Morerar AM, Chauvin MA, Feige JJ, Guillaumot P, Keramidas M, Maudreit C, Sordvillet C, Benahmed M.: Interactions between systemic hormones and local growth factors in the control of the testis function: the example of gonadotropins and transforming growth factor \. Serono Symp. Publ. 1990, 70:191.

  14. 14

    -Orth I, Christensen AK.: Localization of 125 I labeled FSH in the testes of hypophysectomizedo-rats by autoradiography at the light and electron microscope levels. Endocrinology, 1977, 101:262.

  15. 15

    -Saez JM, Avallet O, Naville D, Perrard-Sapori MH, Chatelain PG.: Sertoli-Leydig cell communications. In: “Regulation of testicular function”, Ewing LL et Robaire B eds. Annals of the New York Academy of Sciences, 1989, 564:210.

  16. 16

    -Saez JM, Forest MG.: Kinetics of human choricnic gonadotropin-induced steroidogenic response of the human testis. J. Clin. Endocrinol. Metab., 1979, 49:278.

  17. 17

    -Sharpe RM.: Intratesticular control of steroidogenesis. Clin. Endocrinol., 1990, 33:787.

  18. 18

    -Sharpe RM, Cooper I.: Intratesticular secretion of a factor(s) with major stimulatory effects on Leydig cell testosterone secretion in vitro. Mol. Cell. Endocrinol, 1984, 37:159.

  19. 19

    -Tsatsoulis A, Whitehead E, John J, Shalet SM, Robertson WR: The pituitary Leydig cell axis in men with severe damage to the germinal epithelium. Clin. Endocrinol, 1987, 27:683.

  20. 20

    -Van Beurden WMO, Roodnat B, de Jong F, Mulder E, van der Molen HJ.: Hormonal regulation of LH stimulation of testosterone production in isolated Leydig cells of immature rats: the effect of hypophysectomy, FSH, and estradiol 17\. Steroids, 1976, 28:847.

  21. 21

    -Verhoeven G.: Local control systems within the testes. Baillières Clinical Endocrinology and Metabolism. The Testis de Kretser, ed. 1992, sous presse.

  22. 22

    -Verhoeven G., Cailleau J.: A factor in spent media from Sertoli cell-enriched cultures that stimulates steroidogenesis in Leydig cells. Mol. Cell. Endocrinol., 1985, 40:57.

  23. 23

    -Verhoeven G., Cailleau: J. A Leydig cell stimulatory factor produced by human testicular tubules. Mol. Cell. Endocrinol, 1987, 49:137.

  24. 24

    -Verhoeven G., Cailleau J.: Influence of coculture with Sertoli cells on steroidogenesis in immatur rat Leydig cells. Mol. Cell. Endocrinol. 1990, 71:239.

  25. 25

    -Verhoeven G, Cailleau J.: Rat tumor Leydig cells as a test system for the study of Sertoli cell factors that stimulate steroidogenesis. J. Androl., 1991, 12:9.

  26. 26

    -Verhoeven G, Cailleau J, Swinnen K, Heyns W: Local interactions between tubular and interstitial compartment in the testis. In A. Isidorni, A. Fabri, ML Dufau eds: Hormonal communicating events in the testis. Serono Symposia Publications, 1990, 70:149.

Download references

Author information

Correspondence to G. Verhoeven.

Additional information

Ce texte est le résumé d’un exposé donné à l’occasion de la réunion commune de la Société d’Andrologie de langue française et de la Deutsche Gesellschaft für Andrologie à Strasbourg (Novembre 1991).

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Verhoeven, G. Regulation de la secretion androgenique du testitule. Androl. 2, 3–7 (1992) doi:10.1007/BF03034583

Download citation

Key words

  • Tesus
  • paracrine factors
  • Leydig cells
  • Sertoli cells
  • androgens
  • gonadotrophins

Mots clés

  • testicule
  • facteurs paracrines
  • cellules de Leydig
  • cellules de Sertoli
  • androgènes
  • gonadotrophines