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Regulation de la secretion androgenique du testitule

Regulation of testicular androgen secretion

Abstract

Although LH undoubtedly remains the major factor controlling testicular androgen production, there is increasing evidence for the existence of a complex network of paracrine and autocrine intratesticular factors capable of modulating the development, differenciation and activity of the Leydig cells. This review summarizes the present understanding of intratesticular factors affecting Leydig cell function. Attention has been focussed upon the identification of tubular agonist which might mediate the effects of FSH on the production of androgens by Leydig cells. The findings discussed illustrate that even for such a welldefined function there are many candidates, and that the major agonists remain to be characterized. Moreover, all our present knowledge is based on invitro data, and the in-vivo role of all these agonists remains to be evaluated.

Resume

Bien que la LH reste le principal facteur responsable de la rulation de la sécrétion androgénique du testicule, le développement, la différentiation et l’activité des cellules de Leydig sont également modulés par toute une série de facteurs intratesticulaires. Dans cet article nous avons tenté de donner un aperçu de ce contrôle local (régulations paracrines et/ou endocrines) de la fonction des cellules de Leydig. Nos recherches ont porté sur l’identification de facteurs tubulaires qui pourraient moduler les effets de la FSH sur la production des androgènes. Les données présentées montrent l’existence de nombreux candidats à cette fonction. La plupart de ces molécules agonistes doivent encore être caractérisées. De plus leur rôle exact reste à être évalué in vivo.

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Correspondence to G. Verhoeven.

Additional information

Ce texte est le résumé d’un exposé donné à l’occasion de la réunion commune de la Société d’Andrologie de langue française et de la Deutsche Gesellschaft für Andrologie à Strasbourg (Novembre 1991).

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Verhoeven, G. Regulation de la secretion androgenique du testitule. Androl. 2, 3–7 (1992). https://doi.org/10.1007/BF03034583

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Key words

  • Tesus
  • paracrine factors
  • Leydig cells
  • Sertoli cells
  • androgens
  • gonadotrophins

Mots clés

  • testicule
  • facteurs paracrines
  • cellules de Leydig
  • cellules de Sertoli
  • androgènes
  • gonadotrophines