- Génétique de l’Infertilité Masculine
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Génétique et infertilité masculine: données actuelles
Genetic basis of male infertility: Current data
Andrologie volume 13, pages 134–138 (2003)
Resume
L’injection intracytoplasmique (ICSI) et les prélèvements testiculaires (TESE) ont révolutionné les pratiques et les traitements de l’infertilité masculine en introduisant le risque d’augmenter la fréquence des anomalies génétiques chez la descendance. Il est donc nécessaire d’évaluer ces risques et leurs conséquences quand une ICSI est pratiquée pour un homme infertile. Un certain nombre d’analyses au niveau du caryotype ou des gènes doivent être pratiquées pour dépister certains défauts génétiques responsables de l’infertilité. En particulier, la recherche de microdélétions du chromosome Y doit être effectuée afin d’évaluer le risque qu’un père transmette à son fils le même problème d’infertilité. Le couple peut alors profiter du conseil génétique avant de décider d’une procréation par ICSI.
Abstract
Intracytoplasmic sperm injection (ICSI) and testicular biopsies (TESE) have revolutionized the treatment of male infertility, introducing a risk of an increased frequency of genetic defects in the offspring. These risks and their consequences must therefore be evaluated when proposing ICSI to an infertile man. Karyotype and molecular analysis should be performed to detect any genetic defects responsible for male infertility. Y microdeletion screening is important, not only to define the aetiology of spermatogenic failure, but also to provide information allowing a more appropriate management of both the infertile male and his future male child. Genetic counselling is then advised before deciding to attempt ICSI.
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Szerman, E. Génétique et infertilité masculine: données actuelles. Androl. 13, 134–138 (2003). https://doi.org/10.1007/BF03034427
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DOI: https://doi.org/10.1007/BF03034427