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Génétique et infertilité masculine: données actuelles

Genetic basis of male infertility: Current data

Andrologie volume 13, pages 134–138 (2003)Cite this article

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L’injection intracytoplasmique (ICSI) et les prélèvements testiculaires (TESE) ont révolutionné les pratiques et les traitements de l’infertilité masculine en introduisant le risque d’augmenter la fréquence des anomalies génétiques chez la descendance. Il est donc nécessaire d’évaluer ces risques et leurs conséquences quand une ICSI est pratiquée pour un homme infertile. Un certain nombre d’analyses au niveau du caryotype ou des gènes doivent être pratiquées pour dépister certains défauts génétiques responsables de l’infertilité. En particulier, la recherche de microdélétions du chromosome Y doit être effectuée afin d’évaluer le risque qu’un père transmette à son fils le même problème d’infertilité. Le couple peut alors profiter du conseil génétique avant de décider d’une procréation par ICSI.

Abstract

Intracytoplasmic sperm injection (ICSI) and testicular biopsies (TESE) have revolutionized the treatment of male infertility, introducing a risk of an increased frequency of genetic defects in the offspring. These risks and their consequences must therefore be evaluated when proposing ICSI to an infertile man. Karyotype and molecular analysis should be performed to detect any genetic defects responsible for male infertility. Y microdeletion screening is important, not only to define the aetiology of spermatogenic failure, but also to provide information allowing a more appropriate management of both the infertile male and his future male child. Genetic counselling is then advised before deciding to attempt ICSI.

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Authors and Affiliations

  1. Spermiologie CECOS, Département Génétique et Reproduction, CHU côte de Nacre, 14033, CAEN Cedex

    Ethel Szerman

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  1. Ethel Szerman
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Correspondence to Ethel Szerman.

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Szerman, E. Génétique et infertilité masculine: données actuelles. Androl. 13, 134–138 (2003). https://doi.org/10.1007/BF03034427

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  • DOI: https://doi.org/10.1007/BF03034427

Mots clés

  • infertilité masculine
  • anomalie chromosomique
  • Y chromosome
  • microdélétion

Key-words

  • male Infertility
  • chromosomal abnormality
  • Y chromosome
  • microdeletion

Basic and Clinical Andrology

ISSN: 2051-4190