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  • Cancer du Testicule
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Y-a-t-il des gènes du cancer du testicule?

Are there testicular cancer genes?

Andrologie volume 10, pages 171–180 (2000)Cite this article

Résumé

Y-a-t-il des gènes du cancer du testicule? Pour répondre, il est nécessaire de définir précisément la question posée. Par exemple, les gènes sont-ils la cause du cancer, ou sont-ils les gènes de susceptibilité au cancer, ou sontils associés à des évènements secondaires comme la progression du cancer? La formation du cancer est probablement le résultat d’une interaction complexe entre des facteurs environnementaux et des gènes variants qui peuvent provoquer une susceptibilité au cancer. Ces gènes commencent à être identifiés. Récemment, un locus sur xq a été défini et associé avec quelques cas familiaux de tumeurs des cellules germinales. D’autres réarrangements chromosomiques ont été associés au cancer du testicule, tels que des délétions interstitielles de 5q, de 12q et de l’isochromosome 12p.

Abstract

The reply to this question depends on a precise definition of the question. Does one mean genes that cause tumor formation, genes that are responsible for susceptibility to testicular cancer or genes that are associated with tumor progression? There is little evidence to support gene mutation as a cause of testicular cancer. Cancer formation is probably the result of a complex interaction between environmental factors and gene variants that may give a susceptiblity to cancer. Testicular cancer susceptibility genes are now being mapped. Recently a locus on Xq has been defined that is associated with some familial cases of germ cell tumors. Most of these cases have a history of cryptorchidism, so the locus may be responsible for a susceptibility t undecended testis.

Other chromosomal rearrangements are associated with testicular cancer. These include interstitial deletions of 5q and 12q, and isochromosome 12p. The relationship between these changes and tumor formation or progression has yet to be established. Increasing evidence suggests that the isochromosome 12p may play an important role in testicular cancer, because this chromosomal rearrangment can be detected in carcinoma in situ cells which are considered to be the common ancestor of all types of testicular cancer. Multiple copies of a gene on 12p may influence cancer formation or development. A candidate factor is cyclin D2. This cyclin plays a key role in the progression of the cell cycle. Dysregulation of the cell cycle caused by the presence of an increased dose of cyclin D2 may play an important contribution in testicular cancer.

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  1. Immunogénétique Humaine, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris Cedex

    K. McElreavey

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McElreavey, K. Y-a-t-il des gènes du cancer du testicule?. Androl. 10, 171–180 (2000). https://doi.org/10.1007/BF03034369

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Basic and Clinical Andrology

ISSN: 2051-4190