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Age paternel et descendance

Paternal age and progeny

Andrologie volume 10, pages 155–165 (2000)Cite this article

Résumé

Le vieillissement testiculaire concerne à la fois l’individu et sa descendance. Chez l’individu, les modifications touchant la vascularisation, les cellules endocrines, la barrière hémato-testiculaire et les cellules de Sertoli entraînent une chute du nombre des spermatozoïdes ainsi qu’une altération de leur morphologie et de leur mobilité. Ces changements entraînent une diminution progressive de la fertilité. Chez la descendance, le vieillissement paternel augmente le risque de mutations autosomiques dominantes à l’origine de différentes malformations ou perturbations fonctionnelles et celui de certaines mutations récessives liées au sexe. Il semble en outre responsable d’une diminution de la longévité des filles. Enfin, chez l’animal et l’homme, le très jeune âge et le vieillissement du père s’accompagnent d’une diminution des fonctions cognitives de la progéniture. L’âge maternel ne paraît pas jouer de rôle dans ce phénomène. Dans l’ensemble, ces résultats posent le problème de l’âge optimum de la paternité.

Abstract

Testicular ageing affects at the same time the individual and his lineage. In the individual, vascular, endocrine, blood testis barrier and Sertoli cells changes because of age lead a decrease of spermatozoa number and an alteration in their form and motility. These changes lead a gradual decrease of fertility. In the progeny, paternel ageing increases the risk of new dominant autosomic mutations which themselves cause different malformations or functional disorders and that of certain chromosome X linked recessive mutations. Moreover, it seems responsible for a decrease of daughters’longevity. Finally, in animal an man, very youthful age and paternal are accompanied by a lowering in the level of progeny cognitive functions. Maternal age did not appear to play a part in this event. On the whole, these results pose the problem of the optimum age for fatherhood.

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  1. Andrologie et Biologie de la Procréation CHU BICETRE (Univ. PARIS-SUD), 94275, KREMLIN BICETRE

    M. Auroux

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Auroux, M. Age paternel et descendance. Androl. 10, 155–165 (2000). https://doi.org/10.1007/BF03034367

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Basic and Clinical Andrology

ISSN: 2051-4190