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Inséminations intra-utérines avec sperme du conjoint dans les indications masculines: Influence de l'âge de l'homme

Uterine artificial insemination homologous in couples with male infertility: Role of the husband's age.

Andrologie volume 4, pages 331–340 (1994)Cite this article

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Nous avons analysé les résultats de 492 cycles d'Insémination Artificielle avec sperme du Conjoint (IAC) par voie Intra-Utérine (IU) chez 152 couples en utilisant la méthode des courbes de survie en modèle de Cox. 36 grossesses ont été obtenues. Le taux cumulé de grossesse était de 20% à 3 cycles et de 31% à 6 cycles. L'analyse univariée n'a pas révélé de facteur pronostique de succès. L'analyse multivariée a fait apparaître que l'âge de l'homme ≥ 35 ans était un facteur de mauvais pronostic (p=0,04) de même que l'existence d'une dysovulation. L'âge de la femme > 35 ans contrairement à notre attente n'est pas apparu comme un facteur de pronostic statistiquement significatif après prise en compte des autres facteurs.

Abstract

This paper presents the analysis of 492 cycles of Intra Uterine Artificial Insemination Homologous (IU AIH) in 152 couples with male infertility; 36 pregnancies were achevied. We used the life table method and the Cox model to analyse the results and to determine prognosis factors. Univariate analysis did not disclose any prognostic factor. Multivariate analysis revealed 3 negative prognostic factors: husband's age ≥ 35 years (p: 0.04), dysovulation, secondary infertility in man. On the contrary, secondary infertility in woman and oligozoospermia were found to be of good prognosis. Surprisingly, the wife's age ≥ 35 years did not appear to be of poor prognosis in the multivariate analysis. The husband's age has been shown to play a role in fertility by others authors using the Cox method.

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Authors and Affiliations

  1. Laboratoire de Biologie de la Reproduction, Hôpital Edouard Herriot, Lyon

    C. Mathieu, V. Bied, J. Lornage & J. C. Czyba

  2. Centre d'Information Médicale, Hôtel-Dieu. 1, Lyon

    R. Ecochard

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  1. C. Mathieu
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Mathieu, C., Ecochard, R., Bied, V. et al. Inséminations intra-utérines avec sperme du conjoint dans les indications masculines: Influence de l'âge de l'homme. Androl. 4, 331–340 (1994). https://doi.org/10.1007/BF03034322

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Basic and Clinical Andrology

ISSN: 2051-4190