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Anticorps anti-spermatozoïdes: Revue de la littérature

Antisperm antibodies: Litterature revew

Andrologie volume 4, pages 312–321 (1994)Cite this article

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Les anticorps anti spermatozoïdes seraient responsables d'environ 15% des stérilités. Les mécanismes d'autoimmunisation masculine sont dus à la rupture de la barrière hémotesticulaire. II en résulte une mise en contact des spermatozoïdes et des cellules immuno compétentes. Les principaux tests de mise en évidence des anticorps antispermatozoïdes sont le MAR test et l'IB test. Les recherches actuelles visent, à l'aide d'anticorps monoclonaux, à identifier les antigènes responsables d'autoimmunisation. Naz a caractérisé un antigène (FA1 Ag) qui inhibe la pénétration ovocytaire. Cet anticorps n'est ni immobilisant ni agglutinant et ne peut être détecté par les tests. FA1 Ag pourrait être le récepteur spermatique de la glycoprotéine ZP3 de la zone pellucide.

Abstract

Auto immune infertility represents about 15% of all sterilities. The most commun mechanisms of autoimmunity in males are genitals infections (epidymitis) and traumatisms

(vasectomies, testiculat biopsies). Mixt agglutination reaction test and immunobead test are the most commun tests used for detection of antibodies.

Since 1981, researchs tried to characterize spermatozoa antigens by using polyclonal and monoclonal antibodies. More than 30 antigens had been found during this last decade.

Naz and coll had identified an antigen called FA 1 antigen. FA 1 Ag is a 23 Kd glycoprotein.

Anti FA1 antibodies inhibit binding and penetration of sperm to zona intact mice oocytes and also zona free hamster oocytes. They do so without causing agglutination or immobilization of sperm and by the way they cannot be detected by usual tests.

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  1. Service de Gynécologie Obstétrique, Hôpital de la Croix-Rousse, Lyon

    B. Salle

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Salle, B. Anticorps anti-spermatozoïdes: Revue de la littérature. Androl. 4, 312–321 (1994). https://doi.org/10.1007/BF03034320

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Basic and Clinical Andrology

ISSN: 2051-4190