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  • Le Syndrome de Klinefelter
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Le devenir du Klinefelter

The future of Klinefelter's syndrome

Andrologie volume 4, pages 303–311 (1994)Cite this article

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Le devenir du Syndrome de Klinefelter (SK) au delà de l'âge du dépistage dans l'enfance ou lors de l'incorporation au Service Militaire est mal connu.

33 observations réunies dans des services divers chez des sujets de 20 à 65 ans servent de support à une revue de la littérature; celle-ci permet d'identifier deux groupes de données.

Le premier groupe concerne des facteurs de risque indéterminés car les obervations rapportées restent isolées (hémopathies, processus tumoraux). Les troubles de la régulation glucidique et un hyperinsulinisme paraissent néanmoins plus apparents.

Le deuxième groupe de faits correspond à un risque relatif plus significatif. On y retient le cancer du sein, l'ostéoporose, les ulcères de jambes. Une pathologie dysimmunitaire pourraît être un facteur déterminant de plusieurs circonstances pathologiques.

Les tumeurs testiculaires que l'on pouvait craindre sont en fait des événements rares.

Abstract

Medical prognosis of Klinefelter's Syndrome (KS) has to been elucidate. our knowledge about the future of KS beyond infancy or military enrolement is poor.

We report 33 cases of KS issued from various departments, aged from 20 to 65 years, who served as a support for study of the litterature. It was then possible to determine two groups of risk.

The first group relates undetermined risk factors because reported cases are rare (Various Tumors; Leukemia); however these facts appear surpass a mere coincidence. Abnormal glucid regulation and hyperinsulinism are also described.

The second group of facts relates more meaningful risks as breast carcinoma, osteoporosis and lower leg ulcers. Since patients develop frequently autoimmune diseases, this would be the missing link between some pathologies and the sex anomaly.

Suprisingly testicular tumors are rare in spite of numerous intrinseque factors of risk.

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Authors and Affiliations

  1. Service de Gynécologie-Obstétrique-Pr. Leroy-CHRU-Lille, Lille, France

    J. P. Gasnault & M. Leroy-Billard

  2. Service d'Endocrinologie et Maladies Métaboliques-Pr.JP. Fossati CHRU-Lille, Lille, France

    J. P. Gasnault & D. Dewailly

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  1. J. P. Gasnault
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  2. D. Dewailly
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  3. M. Leroy-Billard
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Gasnault, J.P., Dewailly, D. & Leroy-Billard, M. Le devenir du Klinefelter. Androl. 4, 303–311 (1994). https://doi.org/10.1007/BF03034319

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Basic and Clinical Andrology

ISSN: 2051-4190