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Synthese de la table ronde: “Apport de la Prostaglandine E1 dans l’exploration et le traitement de l’impuissance”

Synposis of a round table on “prostaglandin E1 in the assessment and treatment of impotence”

Abstract

Intracavernosal injections of prostaglandin E1 (PGE1) have induced positive erectile responses in 70% of subjects investigated. Mild pain was reported in 15% of cases, with only 5% describing the pain as annoying. Prolonged erections were uncommon and priapism extremely rare. No systemic or generalised complication has ever been reported in about 1500 subjects. Pharmaco-Döppler, using intracavernosal 10 μg PGE1 injections, and pharmacocavernosometry have been investigated. Self-administered injections are obviously of great interest due to the high prevalence of positive responses and absence of complications. Long-terme tolerance is excellent, far better than with other drugs. PGE1 has also been used, with favourable preliminary findings as a treatment for specific conditions, particularly venous leakage and intractable erectile failure with combined organic and psychogenic lesions. PGE1 is becoming progressively more important in the investigation and management of impotence, principally because of its reliability and innocuous nature.

Resume

L’injection intracaverneuse de PGE1 permet d’obtenir 70% de réponses positives. La douleur n’est gênante que dans 5% des cas. Les érections prolongées sont rares, le priapisme exceptionnel. Aucune complication systémique ou générale n’a été observée. Le pharmaco-döppler et la pharmaco-cavernosométric sont à l’étude, après injection de 10 mcg. En auto injections, la fiabilité est bonne, dose-dépendante, et la tolérance parfaite à long terme. Utilisée comme traitement, en injections intracaverneuses répétées, une impression préliminaire favorable se dégage dans certaines indications (fuites veineuses, impuissance invétérée avec facteurs étiologiques mixtes. L’alprostadil s’impose peu à peu par sa fiabilité et son innocuité.

Author information

Correspondence to Michel Etcheverry.

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Key words

  • Prostaglandin E1
  • pharmacological tests
  • self-administered injections
  • tolerance

Mots clés

  • Prostaglandine E1
  • Pharmacotests
  • Auto-injections
  • Tolérance