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Traitements de l’infertilite masculine par les techniques de micromanipulations ovocytaires: Revue de la litterature

Treatment of male infertility using oocyte micromanipulation techniques: A litterature review

Andrologie volume 2, pages 61–67 (1992)Cite this article

Abstract

During the last few years assisted reproductive technology has seen the introduction of oocyte micromanipulation and sperm microinjection as therapeutic approaches for severe male factor infertility. However, a review of the international literature has revealed that less than 100 pregnancies have been obtained using such techniques. Fertilization rates are extremely variable and influenced by the strictness of the various authors’ criteria for selecting cases. It is concluded that partial zona dissection and zona drilling are less useful than subzonal insemination and intracytoplasmic insemination.

Resume

Depuis quelques années, on assiste, dans le domaine des technologies médicalement assistées, à un engouement pour l’utilisation des micromanipulations comme thérapeutique de l’infertilité masculine. Une revue de la littérature nous a permis de constater qu’à ce jour moins de 100 grossesses ont été obtenues et que les taux de fécondation sont trés variables en fonction de la rigueur de la sélection des cas. Alors que la dissection partielle de la zone pellucide ne semble pas être un technique prometteuse, l’injection de spermatozoides dans l’espace périvitellin ou dans le cytoplasme de l’ovocyte pourrait être promise à un bel avenir.

References

  1. -Acosta AA, Oehniger S, Morshedi M, Swanson RJ, Scott R, Irianni F: Assisted reproduction in the diagnosis and treatment of the male factor. Obstet. Gynaecol. Surv., 1988, 44:1–18.

    Google Scholar 

  2. -Barlow P, Van der Zwalmen P, Delvigne A, Van Hoeck J, Schoysman R, Leroy F: L’assistance à la fécondation de l’ovocyte humain par micromanipulation. Rev. Med. Brux., 1992, 13:13–19.

    PubMed  CAS  Google Scholar 

  3. -Bongso A, Fong CY, Ng SC, Ratman S: Fertilization cleavage and cytogenetics of 48-hour zona-intact and zonafree human unfertilized oocytes reinseminated with donor semen. Fertil. Steril., 1992, 57:129–133.

    PubMed  CAS  Google Scholar 

  4. -Bongso TA, Sathananthan AH, Wong PC, Ratnam SS, Ng SC, Anandakumar C, Ganatra S: Human fertilization by microinjection of immotile spermatozoa. Human Reprod., 1989, 4:175–179.

    CAS  Google Scholar 

  5. -Chang SY, Soong YK, Chang M, Lin PW, Guu HF, Wang ML: A clinical pregnancy after a simple method of zona cutting, cryopreservation and zygote intrafallopian transfer. Fertil. Steril., 1991, 55:420–422.

    PubMed  CAS  Google Scholar 

  6. -Coates TE, Check JH, Choe J, Nowroozi K, Lurie D, Callan C: An evaluation of couples with failure of fertilization in vitro. Human Reprod., 1992, 7:978–981.

    CAS  Google Scholar 

  7. -Cohen J, Alikani M, Malter HE, Adler A, Talansky BE, Rosenwaks Z: Partial zona dissection or subzonal sperm insertion: microsurgical fertilization alternatives based on evaluation of sperm and embryo morphology. Fertil. Steril., 1991, 56:696–706.

    PubMed  CAS  Google Scholar 

  8. -Cohen J, Alikani M, Trowbridge J, Rosenwaks: Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis. Human Reprod., 1992, 7:685–691.

    CAS  Google Scholar 

  9. -Cohen J, Elsner C, Kort H, Malter H, Massey J, Mager MP, Wiemer K: Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Human Reprod., 1990, 5:7–13

    CAS  Google Scholar 

  10. -Cohen J, Malter H, Fehilly C, Wright G, Elsner C, Kort H, Massey J: Implantation of embryos after partial opening of oocyte zona pellucida to facilitate sperm penetration. Lancet., 1988, 2:162.

    Article  PubMed  CAS  Google Scholar 

  11. -Cohen J, Malter H, Wright G, Kort H, Massey J, Mitchell D: Partial zona dissection of human oocytes when failure of zona pellucida penetration is anticipated. Human Reprod., 1989, 4:435–442.

    CAS  Google Scholar 

  12. -Cohen J, Talansky BE, Malter H, Alikani M, Adler A, Reing A, Berkeley A, Graf M, Davis O, Liu H, Bedford JM, Rosenwaks Z: Microsurgical fertilization and teratospermia. Human Reprod., 1991, 6:118–123.

    CAS  Google Scholar 

  13. -Cross NL, Morales P, Overstreet JW, Hanson FW: Induction of acrosome reactions by human zona pellucida. Biol. Reprod., 1988, 38:235–244.

    Article  PubMed  CAS  Google Scholar 

  14. -Demoulin A, Pignon MR, Gerday C, Jouan C, Dubois M: The use of zona-free human oocytes as a test of fertilizing capacity of human spermatozoa. 1992, En préparation.

  15. -Edirisinghe WR, Wales RG, Chapman HM, Yovich JL: Assisted fertilization of mouse oocytes and preleminary results for human oocytes using zona drilling. J. In Vitro Fert. Embryo Transfer., 1991, 8:48–55.

    Article  CAS  Google Scholar 

  16. -Feichtinger W, Strohmer H, Fuhrberg P, Radivojevic K, Antinori S, Pepe G, et al: Photoablation of oocyte zona pellucida by erbium-yag laser for in vitro fertilisation in severe male infertility. Lancet, 1992, 339:811.

    Article  PubMed  CAS  Google Scholar 

  17. -Fishel S, Antinori S, Jackson P, Johnson J, Rinaldi L: Presentation of six pregnancies established by subzonal insemination (SUZI). Human Reprod., 1991, 6:124–130.

    CAS  Google Scholar 

  18. -Fishel S, Jackson P, Antinori S, Johnson J, Grossi S, Versaci C: Subzonal insemination for the alleviation of infertility. Fertil. Steril., 1990, 54:828–833.

    PubMed  CAS  Google Scholar 

  19. -Fishel S, Timson J, Lisi F, Rinaldi L: Evaluation of 225 patients undergoing subzonal insemination for the procurement of fertilization in vitro. Fertil. Steril., 1992, 57:840–849.

    PubMed  CAS  Google Scholar 

  20. -Garrisi GJ, Talansky BE, Grunfeld L, Sapira V, Navot D, Gordon JW: Clinical evaluation of three approaches to micromanipulation-assisted fertilization. Fertil. Steril., 1990, 54:671–677.

    PubMed  CAS  Google Scholar 

  21. -Gerday C, Jouan C, Dubois M, Demoulin A: L’échec de fécondation en FIV: intérêt d’un taux de récolte ovocytaire élevé et étude du taux de récidive. Andrologie 1992, Soumis pour publication.

  22. -Gordon JW, Grunfeld L, Garisi GJ, Talanski BE, Richards C, Lanfer N: Fertilization of human oocytes by sperm from infertile males after zona pellucida drilling. Fertil. Steril., 1988, 50:68–73.

    PubMed  CAS  Google Scholar 

  23. -Gordon JW, Talansky BE: Assisted fertilization by zona drilling: a mouse model for correction of oligospermia. J. Exp. Zool., 1986, 239:347–354.

    Article  PubMed  CAS  Google Scholar 

  24. -Hill DL, Adler D, Rothman C, Surrey M, Danzer H, Friedman S: Micromanipulation in a centre for reproductive medicine. Fertil. Steril., 1991, 55:36–38.

    PubMed  CAS  Google Scholar 

  25. -Jean M, Barriere P, Sagot P: L’Hermite A, Lopes P.: Utility of zona pellucida drilling in cases of severe semen alterations in man. Fertil. Steril., 1992, 57:591–596.

    PubMed  CAS  Google Scholar 

  26. -Jean M, L’Hermite A, Barriere P: Intérêt du «zona drilling” dans les tests de fécondation pré-IAD. Contr. Fertil. Sex., 1990, 18:570–571.

    Google Scholar 

  27. -Johnson MH, Vincent C, Pickering SJ, Cant A, Bruade PR, Currie J: Acid tyrode’s solution can stimulate pathogenetic activation of human and mouse oocytes. Fertil. Steril, 1990, 53:266–270.

    PubMed  CAS  Google Scholar 

  28. -Khalifa E, Oehninger S, Acosta AA, Morshedi M, Veeck L, Bryzyski RG, Muasher SJ: Successful fertilization and pregnancy outcome in in-vitro fertilization using cryopreserved/thawed spermatozoa from patients with malignant diseases. Hum. Reprod., 1992, 7:105–108.

    PubMed  CAS  Google Scholar 

  29. -Kola I, Lachnam O, Jansen RPS, Turner M, Trounson A: Chromosome analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space. Human Reprod., 1990, 5:575–577.

    CAS  Google Scholar 

  30. -Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S: Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil. Steril., 1988, 49:112–117.

    PubMed  CAS  Google Scholar 

  31. -Lanzendorf S, Maloney MK, Veeck LL, Slusser J, Hodgen GD, Rosenwaks Z: A preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. Fertil. Steril; 1988, 49:835–842.

    PubMed  CAS  Google Scholar 

  32. -Lassalle B, Courtot AM, Testart J: In vitro fertilization of hamster and human oocytes by microinjection of human sperm. Gamete Res., 1987, 16:69–78.

    Article  PubMed  CAS  Google Scholar 

  33. -Laufer N, Abrams T, Simon A: Treatment of male infertility by gamete micromanipulation. Focus in Reproduction, 1991, 1:5–9.

    Google Scholar 

  34. -Laws-King A, Trounson A, Sathananthan M, Kola I: Fertilization of human oocytes by microinjection of a single spermatozoon under the zona pellucida. Fertil. Steril; 1987, 48:637–642.

    PubMed  CAS  Google Scholar 

  35. -Lee MA, Trucco GS, Bechtol KB, Wummer N, Kopf GS, Blasco L, Storey BT: Capacitation and acrosomic reactions in human spermatozoa monitored by a chlortetracycline fluorescence assay. Fertil. Steril, 1987, 48:649–658.

    PubMed  CAS  Google Scholar 

  36. -Mahadevan MM, Trounson AO: Removal of the cumulus oophorus from the human oocyte for in vitro fertilization. Fertil. Steril., 1985, 43:263–267.

    PubMed  CAS  Google Scholar 

  37. -Malter HE, Cohen J: Partial zona dissection of the human oocyte: a non traumatic method using micromanipulation to assist zona pellucida penetration. Fertil. Steril, 1989, 51:139–148.

    PubMed  CAS  Google Scholar 

  38. -Malter HE, Cohen J: Embryonic development after microsurgical repair of polyspermic human zygotes. Fertil. Steril., 1989, 52:373–382.

    PubMed  CAS  Google Scholar 

  39. -Malter HE, Talansky B, Gordon J, Cohen J: Monospermy and polyspermy after partial zona dissection of reinseminated human oocytes. Gamete Res., 1989, 23:377–386.

    Article  PubMed  CAS  Google Scholar 

  40. -Markert CL: Fertilization of mammalian eggs by sperm injection. J. Exp. Zool., 1983, 228:195–201.

    Article  PubMed  CAS  Google Scholar 

  41. -Mortimer D, Chorney MJ, Curtis EF, Trounson AD: Calcium dependence of human sperm fertilizing ability. J. Exp. Zool., 1988, 246:194–201.

    Article  PubMed  Google Scholar 

  42. -Ng SC, Bongso A, Chang SI, Sathananthan H, Ratnam S: Transfer of human sperm into the perivitelline space of human oocytes after zona-drilling or zona-puncture. Fertil. Steril., 1989, 52:73–78.

    PubMed  CAS  Google Scholar 

  43. -Ng SC, Bongso A, Ratman SS: Microinjection of human oocytes: a technique for severe oligoasthenoteratospermia. Fertil. Steril, 1991, 56:117–1123.

    Google Scholar 

  44. -Ng SC, Bongso A, Ratnam SS, Sathonanthan H, Chan CLK, Wong PC, Hagglund L, Anandakumar C, Wong YC, Goh VHH: Pregnancy after transfer of sperm under zona. Lancet., 1988, 2:790.

    Article  PubMed  CAS  Google Scholar 

  45. -Ng SC, Bongso A, Sathananthan AH, Ratnam SS: Micromanipulation: its relevance to human in vitro fertilization. Fertil. Steril, 1990, 53:203–219.

    PubMed  CAS  Google Scholar 

  46. -Olar TT, Lanasa J, Dickeky RT, Taylor SN, Curolz DN: Fertilization of human oocytes by microinjection of human sperm aspirated from the caput epididymis of an individual with obstructive azoospermia. J. In vitro Fert. Embryo. Transfer., 1990, 7:160164.

    Article  Google Scholar 

  47. -Palanker D, Ohad S, Lewis A, Simon A, Shenkar J, Penchas S, Laufer N: Technique for cellular microsurgery using the 193-nm excimer laser. Lasers in Surgery and Medicine., 1991, 11:580–586.

    Article  PubMed  CAS  Google Scholar 

  48. -Palermo G, Joris H, Devroey P, Van Steirteghem AC: Induction of acrosome reaction in human spermatozoa used for subzonal insemination. Human Reprod., 1992, 7:248–254.

    CAS  Google Scholar 

  49. -Palermo G, Joris H, Devroey P, Van Steirteghem A: Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. The Lancet., 1992, 340:17–18.

    Article  CAS  Google Scholar 

  50. -Payne D, McLaughlin KJ, Depypere HT, Kirby CA, Warnes GM, Matthews CD: Experience with zona cutting to improve fertilization rates of human oocytes in vitro. Human Reproduction, 1991, 6:423–431.

    PubMed  CAS  Google Scholar 

  51. -Ron-El R, Nachum A, Herman A, Golan A, Caspi E, Soffer Y: Delayed fertilization and poor embryonic development associated with impaired semen quality. Fertil. Steril, 1991, 55:338–344.

    PubMed  CAS  Google Scholar 

  52. -Sakkas D, Lacham O, Gianaroli L, Trounson A: Subzonal sperm microinjection in cases of severe male factor infertility and repeated in vitro fertilization failure. Fertil. Steril, 1992, 57:1279–1288.

    PubMed  CAS  Google Scholar 

  53. -Sathananthan AH, Chen C: Sperm-oocyte membrane fusion in the human during monospermic fertilization. Gamete Res., 1986, 15:177–186.

    Article  Google Scholar 

  54. -Sathananthan AH, Ng SC, Edirisinghe WR, Ratnam SS, Wong PC: Sperm-oocyte interaction in the human during polyspermic fertilization in vitro. Gamete Res., 1986, 15:317–326.

    Article  Google Scholar 

  55. -Sathananthan AH, Ng SC, Trounson A, Bongso A, Laws-King A, Ratman SS: Human microinsemination by injection of single or multiple sperm: ultrastructure. Human Reprod., 1989, 4:574–583.

    CAS  Google Scholar 

  56. -Sathananthan AH, Trounson AO: Ultrastructure of cortical granule release and zona interaction in monospermic and polyspermic human ova fertilized in vitro. Gamete Res., 1982, 6: 225–234.

    Article  Google Scholar 

  57. -Siiteri JE, Dandekar P, Meizel S: Human sperm acrosome reaction-initiating activity associated with the human cumulus oophorus and mural granulosa cells. J. Exp. Zool., 1986, 246: 71–80.

    Article  Google Scholar 

  58. -Simon A, Younis J, Lewin A, Bartoov B, Schenker JG, Laufer N: The correlation between sperm cell morphology and fertilization after zona pellucida slitting in subfertile males. Fertil. Steril, 1991, 56: 325–331.

    PubMed  CAS  Google Scholar 

  59. -Stock CE, Bates R, Lindsay KS, Edmonds DK, Fraser LR: Human oocyte cumulus complexes stimulate the human acrosome reaction. J. Reprod. Fertil., 1989, 86:723–730.

    Article  PubMed  CAS  Google Scholar 

  60. -Tadir Y, Wright WH, Vafa O, Liaw LH, Asch R, Berns MW: Micromanipulation of gametes using laser microbeams. Human Reprod., 1991, 7:1011–1016.

    Google Scholar 

  61. -Tucker MJ, Bishop FM, Cohen J, Weker SR, Wright G: Routine application of partial zona dissection for male factor infertility. Human Reprod., 1991, 6:676–681.

    CAS  Google Scholar 

  62. -Van Der Zwalmen P, Barlow P, Nijs M, Bertin G, Leroy F, Schoysman R: Usefulness of partial zona dissection of the zona pellucida in an in vitro fertilization programme. Human Reprod., 1992, 7:537–544.

    Google Scholar 

  63. -Veeck LL, Oehninger S, Acosta AA, Muasher SJ: Sperm microinjection in a clinical in vitro fertilization program. 45th annual meeting of the AFS. Abstract O-121. Fertil. Steril, Suppl 1989, pp S50–S51.

  64. -Wittemer C, Moreau L, Dellenbach P, Gerlinger P, Le Meur MA, Chambon P: A case of human pregnancy after microinjection of capacitated sperm into the perivitelline space. J. In vitro Fert. Embryo Transfer. 1991, 8:222–224.

    Article  CAS  Google Scholar 

  65. -Wolf JP, Jouannet P: Intérêt des méthodes de microfécondation dans l’infertilité masculine. 30e réunion de la Société fran-aise pour l’étude de la fertilité. Paris, 3–4 octobre 1991. Contr. Sex. 1991, 19: 168–176.

    Google Scholar 

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  1. Centre de Procréation Médicalement Assistée, Université de Liège CHR Citadelle, 1, Bd du 12è de Ligne, 4000, Liège, Belgique

    A. Demoulin

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Demoulin, A. Traitements de l’infertilite masculine par les techniques de micromanipulations ovocytaires: Revue de la litterature. Androl. 2, 61–67 (1992). https://doi.org/10.1007/BF03034221

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Basic and Clinical Andrology

ISSN: 2051-4190