Skip to main content

Advertisement

Traitements de l’infertilite masculine par les techniques de micromanipulations ovocytaires: Revue de la litterature

Treatment of male infertility using oocyte micromanipulation techniques: A litterature review

Article metrics

  • 279 Accesses

Abstract

During the last few years assisted reproductive technology has seen the introduction of oocyte micromanipulation and sperm microinjection as therapeutic approaches for severe male factor infertility. However, a review of the international literature has revealed that less than 100 pregnancies have been obtained using such techniques. Fertilization rates are extremely variable and influenced by the strictness of the various authors’ criteria for selecting cases. It is concluded that partial zona dissection and zona drilling are less useful than subzonal insemination and intracytoplasmic insemination.

Resume

Depuis quelques années, on assiste, dans le domaine des technologies médicalement assistées, à un engouement pour l’utilisation des micromanipulations comme thérapeutique de l’infertilité masculine. Une revue de la littérature nous a permis de constater qu’à ce jour moins de 100 grossesses ont été obtenues et que les taux de fécondation sont trés variables en fonction de la rigueur de la sélection des cas. Alors que la dissection partielle de la zone pellucide ne semble pas être un technique prometteuse, l’injection de spermatozoides dans l’espace périvitellin ou dans le cytoplasme de l’ovocyte pourrait être promise à un bel avenir.

References

  1. 1

    -Acosta AA, Oehniger S, Morshedi M, Swanson RJ, Scott R, Irianni F: Assisted reproduction in the diagnosis and treatment of the male factor. Obstet. Gynaecol. Surv., 1988, 44:1–18.

  2. 2

    -Barlow P, Van der Zwalmen P, Delvigne A, Van Hoeck J, Schoysman R, Leroy F: L’assistance à la fécondation de l’ovocyte humain par micromanipulation. Rev. Med. Brux., 1992, 13:13–19.

  3. 3

    -Bongso A, Fong CY, Ng SC, Ratman S: Fertilization cleavage and cytogenetics of 48-hour zona-intact and zonafree human unfertilized oocytes reinseminated with donor semen. Fertil. Steril., 1992, 57:129–133.

  4. 4

    -Bongso TA, Sathananthan AH, Wong PC, Ratnam SS, Ng SC, Anandakumar C, Ganatra S: Human fertilization by microinjection of immotile spermatozoa. Human Reprod., 1989, 4:175–179.

  5. 5

    -Chang SY, Soong YK, Chang M, Lin PW, Guu HF, Wang ML: A clinical pregnancy after a simple method of zona cutting, cryopreservation and zygote intrafallopian transfer. Fertil. Steril., 1991, 55:420–422.

  6. 6

    -Coates TE, Check JH, Choe J, Nowroozi K, Lurie D, Callan C: An evaluation of couples with failure of fertilization in vitro. Human Reprod., 1992, 7:978–981.

  7. 7

    -Cohen J, Alikani M, Malter HE, Adler A, Talansky BE, Rosenwaks Z: Partial zona dissection or subzonal sperm insertion: microsurgical fertilization alternatives based on evaluation of sperm and embryo morphology. Fertil. Steril., 1991, 56:696–706.

  8. 8

    -Cohen J, Alikani M, Trowbridge J, Rosenwaks: Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis. Human Reprod., 1992, 7:685–691.

  9. 9

    -Cohen J, Elsner C, Kort H, Malter H, Massey J, Mager MP, Wiemer K: Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Human Reprod., 1990, 5:7–13

  10. 10

    -Cohen J, Malter H, Fehilly C, Wright G, Elsner C, Kort H, Massey J: Implantation of embryos after partial opening of oocyte zona pellucida to facilitate sperm penetration. Lancet., 1988, 2:162.

  11. 11

    -Cohen J, Malter H, Wright G, Kort H, Massey J, Mitchell D: Partial zona dissection of human oocytes when failure of zona pellucida penetration is anticipated. Human Reprod., 1989, 4:435–442.

  12. 12

    -Cohen J, Talansky BE, Malter H, Alikani M, Adler A, Reing A, Berkeley A, Graf M, Davis O, Liu H, Bedford JM, Rosenwaks Z: Microsurgical fertilization and teratospermia. Human Reprod., 1991, 6:118–123.

  13. 13

    -Cross NL, Morales P, Overstreet JW, Hanson FW: Induction of acrosome reactions by human zona pellucida. Biol. Reprod., 1988, 38:235–244.

  14. 14

    -Demoulin A, Pignon MR, Gerday C, Jouan C, Dubois M: The use of zona-free human oocytes as a test of fertilizing capacity of human spermatozoa. 1992, En préparation.

  15. 15

    -Edirisinghe WR, Wales RG, Chapman HM, Yovich JL: Assisted fertilization of mouse oocytes and preleminary results for human oocytes using zona drilling. J. In Vitro Fert. Embryo Transfer., 1991, 8:48–55.

  16. 16

    -Feichtinger W, Strohmer H, Fuhrberg P, Radivojevic K, Antinori S, Pepe G, et al: Photoablation of oocyte zona pellucida by erbium-yag laser for in vitro fertilisation in severe male infertility. Lancet, 1992, 339:811.

  17. 17

    -Fishel S, Antinori S, Jackson P, Johnson J, Rinaldi L: Presentation of six pregnancies established by subzonal insemination (SUZI). Human Reprod., 1991, 6:124–130.

  18. 18

    -Fishel S, Jackson P, Antinori S, Johnson J, Grossi S, Versaci C: Subzonal insemination for the alleviation of infertility. Fertil. Steril., 1990, 54:828–833.

  19. 19

    -Fishel S, Timson J, Lisi F, Rinaldi L: Evaluation of 225 patients undergoing subzonal insemination for the procurement of fertilization in vitro. Fertil. Steril., 1992, 57:840–849.

  20. 20

    -Garrisi GJ, Talansky BE, Grunfeld L, Sapira V, Navot D, Gordon JW: Clinical evaluation of three approaches to micromanipulation-assisted fertilization. Fertil. Steril., 1990, 54:671–677.

  21. 21

    -Gerday C, Jouan C, Dubois M, Demoulin A: L’échec de fécondation en FIV: intérêt d’un taux de récolte ovocytaire élevé et étude du taux de récidive. Andrologie 1992, Soumis pour publication.

  22. 22

    -Gordon JW, Grunfeld L, Garisi GJ, Talanski BE, Richards C, Lanfer N: Fertilization of human oocytes by sperm from infertile males after zona pellucida drilling. Fertil. Steril., 1988, 50:68–73.

  23. 23

    -Gordon JW, Talansky BE: Assisted fertilization by zona drilling: a mouse model for correction of oligospermia. J. Exp. Zool., 1986, 239:347–354.

  24. 24

    -Hill DL, Adler D, Rothman C, Surrey M, Danzer H, Friedman S: Micromanipulation in a centre for reproductive medicine. Fertil. Steril., 1991, 55:36–38.

  25. 25

    -Jean M, Barriere P, Sagot P: L’Hermite A, Lopes P.: Utility of zona pellucida drilling in cases of severe semen alterations in man. Fertil. Steril., 1992, 57:591–596.

  26. 26

    -Jean M, L’Hermite A, Barriere P: Intérêt du «zona drilling” dans les tests de fécondation pré-IAD. Contr. Fertil. Sex., 1990, 18:570–571.

  27. 27

    -Johnson MH, Vincent C, Pickering SJ, Cant A, Bruade PR, Currie J: Acid tyrode’s solution can stimulate pathogenetic activation of human and mouse oocytes. Fertil. Steril, 1990, 53:266–270.

  28. 28

    -Khalifa E, Oehninger S, Acosta AA, Morshedi M, Veeck L, Bryzyski RG, Muasher SJ: Successful fertilization and pregnancy outcome in in-vitro fertilization using cryopreserved/thawed spermatozoa from patients with malignant diseases. Hum. Reprod., 1992, 7:105–108.

  29. 29

    -Kola I, Lachnam O, Jansen RPS, Turner M, Trounson A: Chromosome analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space. Human Reprod., 1990, 5:575–577.

  30. 30

    -Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S: Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil. Steril., 1988, 49:112–117.

  31. 31

    -Lanzendorf S, Maloney MK, Veeck LL, Slusser J, Hodgen GD, Rosenwaks Z: A preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. Fertil. Steril; 1988, 49:835–842.

  32. 32

    -Lassalle B, Courtot AM, Testart J: In vitro fertilization of hamster and human oocytes by microinjection of human sperm. Gamete Res., 1987, 16:69–78.

  33. 33

    -Laufer N, Abrams T, Simon A: Treatment of male infertility by gamete micromanipulation. Focus in Reproduction, 1991, 1:5–9.

  34. 34

    -Laws-King A, Trounson A, Sathananthan M, Kola I: Fertilization of human oocytes by microinjection of a single spermatozoon under the zona pellucida. Fertil. Steril; 1987, 48:637–642.

  35. 35

    -Lee MA, Trucco GS, Bechtol KB, Wummer N, Kopf GS, Blasco L, Storey BT: Capacitation and acrosomic reactions in human spermatozoa monitored by a chlortetracycline fluorescence assay. Fertil. Steril, 1987, 48:649–658.

  36. 36

    -Mahadevan MM, Trounson AO: Removal of the cumulus oophorus from the human oocyte for in vitro fertilization. Fertil. Steril., 1985, 43:263–267.

  37. 37

    -Malter HE, Cohen J: Partial zona dissection of the human oocyte: a non traumatic method using micromanipulation to assist zona pellucida penetration. Fertil. Steril, 1989, 51:139–148.

  38. 38

    -Malter HE, Cohen J: Embryonic development after microsurgical repair of polyspermic human zygotes. Fertil. Steril., 1989, 52:373–382.

  39. 39

    -Malter HE, Talansky B, Gordon J, Cohen J: Monospermy and polyspermy after partial zona dissection of reinseminated human oocytes. Gamete Res., 1989, 23:377–386.

  40. 40

    -Markert CL: Fertilization of mammalian eggs by sperm injection. J. Exp. Zool., 1983, 228:195–201.

  41. 41

    -Mortimer D, Chorney MJ, Curtis EF, Trounson AD: Calcium dependence of human sperm fertilizing ability. J. Exp. Zool., 1988, 246:194–201.

  42. 42

    -Ng SC, Bongso A, Chang SI, Sathananthan H, Ratnam S: Transfer of human sperm into the perivitelline space of human oocytes after zona-drilling or zona-puncture. Fertil. Steril., 1989, 52:73–78.

  43. 43

    -Ng SC, Bongso A, Ratman SS: Microinjection of human oocytes: a technique for severe oligoasthenoteratospermia. Fertil. Steril, 1991, 56:117–1123.

  44. 44

    -Ng SC, Bongso A, Ratnam SS, Sathonanthan H, Chan CLK, Wong PC, Hagglund L, Anandakumar C, Wong YC, Goh VHH: Pregnancy after transfer of sperm under zona. Lancet., 1988, 2:790.

  45. 45

    -Ng SC, Bongso A, Sathananthan AH, Ratnam SS: Micromanipulation: its relevance to human in vitro fertilization. Fertil. Steril, 1990, 53:203–219.

  46. 46

    -Olar TT, Lanasa J, Dickeky RT, Taylor SN, Curolz DN: Fertilization of human oocytes by microinjection of human sperm aspirated from the caput epididymis of an individual with obstructive azoospermia. J. In vitro Fert. Embryo. Transfer., 1990, 7:160164.

  47. 47

    -Palanker D, Ohad S, Lewis A, Simon A, Shenkar J, Penchas S, Laufer N: Technique for cellular microsurgery using the 193-nm excimer laser. Lasers in Surgery and Medicine., 1991, 11:580–586.

  48. 48

    -Palermo G, Joris H, Devroey P, Van Steirteghem AC: Induction of acrosome reaction in human spermatozoa used for subzonal insemination. Human Reprod., 1992, 7:248–254.

  49. 49

    -Palermo G, Joris H, Devroey P, Van Steirteghem A: Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. The Lancet., 1992, 340:17–18.

  50. 50

    -Payne D, McLaughlin KJ, Depypere HT, Kirby CA, Warnes GM, Matthews CD: Experience with zona cutting to improve fertilization rates of human oocytes in vitro. Human Reproduction, 1991, 6:423–431.

  51. 51

    -Ron-El R, Nachum A, Herman A, Golan A, Caspi E, Soffer Y: Delayed fertilization and poor embryonic development associated with impaired semen quality. Fertil. Steril, 1991, 55:338–344.

  52. 52

    -Sakkas D, Lacham O, Gianaroli L, Trounson A: Subzonal sperm microinjection in cases of severe male factor infertility and repeated in vitro fertilization failure. Fertil. Steril, 1992, 57:1279–1288.

  53. 53

    -Sathananthan AH, Chen C: Sperm-oocyte membrane fusion in the human during monospermic fertilization. Gamete Res., 1986, 15:177–186.

  54. 54

    -Sathananthan AH, Ng SC, Edirisinghe WR, Ratnam SS, Wong PC: Sperm-oocyte interaction in the human during polyspermic fertilization in vitro. Gamete Res., 1986, 15:317–326.

  55. 55

    -Sathananthan AH, Ng SC, Trounson A, Bongso A, Laws-King A, Ratman SS: Human microinsemination by injection of single or multiple sperm: ultrastructure. Human Reprod., 1989, 4:574–583.

  56. 56

    -Sathananthan AH, Trounson AO: Ultrastructure of cortical granule release and zona interaction in monospermic and polyspermic human ova fertilized in vitro. Gamete Res., 1982, 6: 225–234.

  57. 57

    -Siiteri JE, Dandekar P, Meizel S: Human sperm acrosome reaction-initiating activity associated with the human cumulus oophorus and mural granulosa cells. J. Exp. Zool., 1986, 246: 71–80.

  58. 58

    -Simon A, Younis J, Lewin A, Bartoov B, Schenker JG, Laufer N: The correlation between sperm cell morphology and fertilization after zona pellucida slitting in subfertile males. Fertil. Steril, 1991, 56: 325–331.

  59. 59

    -Stock CE, Bates R, Lindsay KS, Edmonds DK, Fraser LR: Human oocyte cumulus complexes stimulate the human acrosome reaction. J. Reprod. Fertil., 1989, 86:723–730.

  60. 60

    -Tadir Y, Wright WH, Vafa O, Liaw LH, Asch R, Berns MW: Micromanipulation of gametes using laser microbeams. Human Reprod., 1991, 7:1011–1016.

  61. 61

    -Tucker MJ, Bishop FM, Cohen J, Weker SR, Wright G: Routine application of partial zona dissection for male factor infertility. Human Reprod., 1991, 6:676–681.

  62. 62

    -Van Der Zwalmen P, Barlow P, Nijs M, Bertin G, Leroy F, Schoysman R: Usefulness of partial zona dissection of the zona pellucida in an in vitro fertilization programme. Human Reprod., 1992, 7:537–544.

  63. 63

    -Veeck LL, Oehninger S, Acosta AA, Muasher SJ: Sperm microinjection in a clinical in vitro fertilization program. 45th annual meeting of the AFS. Abstract O-121. Fertil. Steril, Suppl 1989, pp S50–S51.

  64. 64

    -Wittemer C, Moreau L, Dellenbach P, Gerlinger P, Le Meur MA, Chambon P: A case of human pregnancy after microinjection of capacitated sperm into the perivitelline space. J. In vitro Fert. Embryo Transfer. 1991, 8:222–224.

  65. 65

    -Wolf JP, Jouannet P: Intérêt des méthodes de microfécondation dans l’infertilité masculine. 30e réunion de la Société fran-aise pour l’étude de la fertilité. Paris, 3–4 octobre 1991. Contr. Sex. 1991, 19: 168–176.

Download references

Author information

Correspondence to A. Demoulin.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Demoulin, A. Traitements de l’infertilite masculine par les techniques de micromanipulations ovocytaires: Revue de la litterature. Androl. 2, 61–67 (1992) doi:10.1007/BF03034221

Download citation

Key words

  • Male infertility
  • Micromanipulation
  • Microinjection
  • PZD
  • SUZI
  • ICSI
  • IVF

Mots clés

  • Micromanipulation
  • Microinjection
  • PZD
  • SUZI
  • ICSI
  • FIVETE