Skip to main content

Le transit epididymo-deferentiel

Sperm transport through the epididymis and vas deferens

Abstract

The epididymis and vas deferens constitute not only a simple conduit for sperm transport but also play an important physiological role in the development of sperm fertilizing ability. The epithelial compartment plays a major functional role in determining the biochemical composition of the luminal fluid in which the spermatozoa undergo a series of structural, biochemical and metabolic changes. During epididymal transit spermatozoa acquire their capacity for motility and also their ability to attach and bind to the zona pellucida and fertilize the oocyte. In man, sperm maturation may occur in the extreme proximal region of the epididymis. The regulation of epididymal and vasa deferential function, as well as sperm maturation, are under androgenic control

Resume

Le conduit épididymo-déférentiel assure non seulement le transport mais l’acquisition du pouvoir fécondant des spermatozoïdes. Les fonctions du compartiment épithélial jouent un rôle déterminant dans la composition du liquide intraluminal dans lequel les spermatozoïdes subissent des modifications structurales, biochimiques et métaboliques. Durant le transit dans l’épididyme, les spermatozoïdes acquièrent leur mobilité et l’aptitude à se fixer sur la zone pellucide et à féconder l’ovocyte. Chez l’homme, la maturation des spermatozoïdes peut se produire dans la portion plus proximale du conduit épididymaire. La régulation des fonctiolls de l’épididyme et du canal déférent ainsi que la maturation des spermatozoïdes sont sous le contrôle des androgènes

References

  1. 1

    -Alnann RP: A critical review of methods for evaluation of spermatogenesis from seminal characteristics. J Androl, 1981, 2: 37–58

    Google Scholar 

  2. 2

    -Blaquier JA, Cameo MS, Dawidowski A, Gonzalez Echeverria F, Sanjurjo C: On the role of epididymal factors in sperm maturation in man. In Perspectives in Andrology, Serio M, ed, Serono Symposia Publications, New York, Raven Press, 1989, 53: 37–44.

    Google Scholar 

  3. 3

    -Beckman WC Jr, Fried PA, Stafford SJ, Mickey DD: Autoradiographic localization of tritiumlabeled in human vas deferens. J Androl, 1986, 7: 97–202.

    Google Scholar 

  4. 4

    -Chinoy NJ: Structure and physiology of mammalian vas deferens in relation to fertility regulation. J Biosci, 1985, 7: 215–221.

    Article  Google Scholar 

  5. 5

    -Cooper TG: The Epididymis, Speam maturation and Fertilization. Springer Verlag Heidelberg, 1986.

    Google Scholar 

  6. 6

    -Cooper TG: In defense of a function for the human epididymis. Fertil Steril, 1990, 54: 965–975.

    PubMed  CAS  Google Scholar 

  7. 7

    -Cooper TG: Secretory proteins from the epididymis and their clinical relevance. Andrologia, 1990, 22: 155–165.

    PubMed  Article  Google Scholar 

  8. 8

    -Dacheux JL, Chevrier C, Lanson Y: Motility and surface transformations of human spermatozoa during epididymal transit. Proc Nat Acad Sci, 1987, 513: 560–563.

    Article  Google Scholar 

  9. 9

    -Dadoune JP. Modifications nucléaires des spermatides et des spermatozoïdes. Evaluation de la maturité nucléaire. Contr. Fertil Sex, 1991, 19: 833–839

    Google Scholar 

  10. 10

    -Delpech S, Lecomte P, Lecomte C: Etude in vitro chez l’homme de la liaison des spermatozoïdes épididymaires à la zona pellucida, J Gynecol Obstet Biol Reprod, 1988, 17: 339–342.

    CAS  Google Scholar 

  11. 11

    -Felden F, Leheup B, Fremont S et al.: The plasma membrane of epididymal epithelial cells has specific receptor which binds to androgen binding protein and sex steroid-binding protein. J Steroid Biochem Molec Biol, 1992, 42: 279–285

    PubMed  Article  CAS  Google Scholar 

  12. 12

    -Junera HR, Alfonsi MF, Fain-Maurel MA, Dadoune JP: Characterization of regional proteins in tissues and fluids in the human epididymis. Reprod Nutr Develop, 1988, 28: 1267–1273.

    Article  CAS  Google Scholar 

  13. 13

    -Mathieu C, Guérin JF, Cognat M, Lejeune H, Pinatel MC, Lornage J: Motility and fertilizing capacity of epididymal human spermatozoa in normal and pathological cases, Fertil Steril, 1992, 57: 871–876.

    PubMed  CAS  Google Scholar 

  14. 14

    -Murakami M, Sugita A, Hamasaki M. The vas deferens in man and monkey: spermiophagy in its ampulla. In: Atlas of human reproduction by scanning electron microscopy. 1982 E. Hafez, P Keneman eds, Lancaster, Boston, the Hague MTP Press limited, pp: 187–195.

    Google Scholar 

  15. 15

    -Nagdas SK, Skudlarek M, Orgebin-Christ MC, Tulsiani DRP: Biochemical alterations in the proacrosin-acrosin system during epididymal maturation of the rat spermatozoa. J Androl, 1992, 13: 36–43.

    PubMed  CAS  Google Scholar 

  16. 16

    -Orgebin-Christ MC. Physiologie de l’épididyme et maturation du sperme: état actuel des connaisances. Contr. Fertil Sex, 1986: 14: 487–495.

    Google Scholar 

  17. 17

    -Robaire B, Hermo L: Efferents ducts, epididymis and vas deferens: structure, functions and their regulation. In: The Physiology of Reproduction. E. Knobil, J. Neil et al eds, Raven Press New York, 1988, 1: 999–1080.

    Google Scholar 

  18. 18

    -Ross P, Kan FWK, Antaki P, Vigneault N, Chapdelaine A, Roberts KD: Protein synthesis and secretion in the human epididymis and immunoreactivity with sperm antibodies. Mol. Reprod. Dev. 1990, 26: 1223.

    Article  Google Scholar 

  19. 19

    -Rowley MJ, Teshima F, Heller CG: Duration of transit of spermatozoa through the human male ductulal system. Fertil. Steril, 1970, 21: 390–395.

    PubMed  CAS  Google Scholar 

  20. 20

    -Schoysman RJ, Bedford JM: The role of the human epididymis in sperm maturation and sperm storage as reflected in the consequences of epididymovasostomy. Fertil Steril, 1986, 46: 293–299.

    PubMed  CAS  Google Scholar 

  21. 21

    -Silber SJ: Apparent fertility of human spermatozoa from the caput epididymis. J Androl, 1989, 10: 263–269.

    PubMed  CAS  Google Scholar 

  22. 22

    -Taragnat C, Berger M, Jean CI. Identification and androgen-dependence of proteins in the mouse vas deferens. Int J Androl, 1986, 9: 299–311.

    PubMed  Article  CAS  Google Scholar 

  23. 23

    -Yeung CH, Cooper TG, Senge T: Histochemical localization and quantification of α-glucosidase in the epididymis of men and laboratory animals. Biol Reprod, 1990, 42: 69–676.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jean -Pierre Dadoune.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dadoune, J.-. Le transit epididymo-deferentiel. Androl. 2, 44–47 (1992). https://doi.org/10.1007/BF03034213

Download citation

Key words

  • epididymis
  • Vas deferens
  • Physiology
  • Sperm maturation

Mots clés

  • Epididyme
  • Canal déférent
  • Physiologie
  • Maturation des spermatozoïdes