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Les proteines majeures de la secretion prostatique

Major prostatic secretory proteins

Andrologie volume 1, pages 56–58 (1991)Cite this article

Abstract

Human prostatic secretion contains only a few major proteins among which one finds albumin, acid phosphatase, prostate specific antigen (PSA), prostatic secretory protein of 94 amino acids (PSP94), Zn-α2-glycoprotein and α1-acid glycoprotein. The roles of most of these proteins are not entirely known. However, PSA has been shown to contribute to the hydrolysis of the seminal coagulum proteins. Probable roles for the other components include modifications of the properties of spermatozoa surface and control of inflammatory responses in male and female urogenital tracts.

Resume

La sécrétion prostatique humaine ne contient que quelques protéines majeures parmi lesquelles on retrouve l’albumine, la phosphatase acide, l’antigène spécifique à la prostate (PSA), la protéine de sécrétion de 94 acides aminés (PSP94), la Zn-α2-glycoprotéine et l’α1-glycoprotéine. Le rôle de la plupart de ces protéines n’est pas entièrement connu. On sait toutefois que le PSA contribue à l’hydrolyse des protéines du coagulum formé lors de l’éjaculation. Les rôles probables des autres constituants incluent l’altération des propriétés de surface du spermatozoïde et le contrôle des réponses inflammatoires dans les tractus urogénitaux de l’homme et de la femme.

References

  1. -Araki T, Gejyo F, Takagaki K, Haupt H, Schwick HC, Burgi W, Marti T, Schaller J, Rickli E, Brossmer R, Atkinson PH, Putnam FW, Schmid K. Complete amino acid sequence of human plasma Zn-α2-glycoprotein and its homology to histo compatibility antigens. Proceed. Natl Acad. Sci. (USA), 1988, 85:679–683.

    Article  CAS  Google Scholar 

  2. -Chantananukul W, Panyim S. In vitro specific phosphorylation of the human seminal proteins. Andrologia, 1982, 14:447–453.

    Article  PubMed  CAS  Google Scholar 

  3. -Dubé JY, Frenette G, Paquin R, Chapdelaine P, Tremblay J, Tremblay RR, Lazure C, Seidah N, Chrétien M. Isolation from human seminal plasma of an abundant 16 kDa protein originating from the prostate. Its identification with a 94-residue peptide described as ß-inhibin. J. Andrology, 1987, 8:182–189.

    Google Scholar 

  4. -Dubé JY, Paradis G, Têtu B, Tremblay RR. Synthesis of α1-acid glycoprotein by the human prostate. Prostate, 1989, 15:251–258.

    Article  PubMed  Google Scholar 

  5. -Eliasson R. Biochemical analysis of semen. Int. J. Androl., 1982, Suppl 5:109–119.

    Article  Google Scholar 

  6. -Frenette G, Tremblay RR, Dubé JY. Zinc binding to major human seminal coagulum proteins. Arch. Androl., 1989, 23:155–163.

    Article  PubMed  CAS  Google Scholar 

  7. -Frenette G, Dubé JY, Lazure C, Paradis G, Chrétien M, Tremblay RR. The major 40 kDa glycoprotein in human prostatic fluid is identifical to Zn-α2-glycoprotein. Prostate, 1987, 11:257–270.

    Article  PubMed  CAS  Google Scholar 

  8. -Haagensen DE, Mazoujian G. Biochemistry and immunochemistry of fluid proteins in the breast in gross cystic disease. In “Diseases of the Breast” 3rd edition, Cann C. ed., W. B. Saunders Co, 1986:474–500.

  9. -Lilja H, Abrahamsson PA, Lundwall A. Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. J. Biol. Chem., 1989, 264:1894–1900.

    PubMed  CAS  Google Scholar 

  10. -Lilja H, Laurell CB. Liquefaction of coagulated human semen. Scand. J. Clin. Lab. Invest., 1984, 44:447–452.

    Article  PubMed  CAS  Google Scholar 

  11. -Lilja H, Oldbring J, Rannevik G, Laurell CB. Seminal vesicle secreted proteins and their reactions during gelation and liquefaction of human semen. J. Clin. Invest., 1987, 80:281–285.

    Article  PubMed  CAS  Google Scholar 

  12. -Lin MF, Clinton GM. Human protastic acid phosphatase has phosphotyrosyl protein phosphatase activity. Biochem. J., 1986, 235:351–357.

    PubMed  CAS  Google Scholar 

  13. -Lizana JA, Eneroth P. Proteins in seminal plasma and cervicovaginal secretions. In “Proteins in body fluids, amino acids and tumor markers: diagnostic and clinical aspects”, Alan R. Liss Inc., New York, 1983:271–274.

    Google Scholar 

  14. -Polak B, Daunter B. Seminal plasma biochemistry. IV: Enzymes involved in the liquefaction of human seminal plasma. Int. J. Androl., 1989, 12:187–194.

    Article  PubMed  CAS  Google Scholar 

  15. -Putnam FW. The plasma proteins. Structure, function, and genetic control. Volume IV, 2nd edition, Academic Press, Orlando, 1984, 420 pp.

    Google Scholar 

  16. -Serrano JA, Wasserkrug HL, Serrano AA, Paul BD, Seligman AM. The histochemical demonstration of human prostatic acid phosphatase with phosphorylcholine. Invest. Urol., 1977, 15:123–136.

    PubMed  CAS  Google Scholar 

  17. -Sharief FS, Lee H, Leudermann MM, Lundwall A, Deaven LL, Lee CL, Li SSL. Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. Biochem. Biophys. Res. Commun., 1989, 160:79–86.

    Article  PubMed  CAS  Google Scholar 

  18. -Ulvsback M, Lindstrom C, Weiber H, Abrahamsson PA, Lilja H, Lundwall A. Molecular cloning of a small prostate protein known as β microsemino-protein, PSP94 or β inhibin and demonstration of transcripts in non genital tissues. Biochem. Biophys. Res. Commun., 1989, 164:1310–1315.

    Article  PubMed  CAS  Google Scholar 

  19. -Wang MC, Valenzuela LA, Murphy GP, Chu TM. Purification of a human prostate specific antigen. Invest. Urol., 1979, 17:159–163.

    PubMed  CAS  Google Scholar 

  20. -Watt KWK, Lee PJ, M’Timkulu T, Chan WP, Loor R. Human prostate specific antigen: structural and functional similarity with serine proteases. Proceed. Natl Acad. Sci (USA), 1986, 83:3166–3170.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Biorégulation hormonale, Centre Hospitalier de l’Université Laval, 2705, boul. Laurier, G1V 4G2, Ste-Foy, Québec, Canada

    Jean Y. Dubé (Professeur titulaire)

  2. Dépt. de médecine, Université Laval, Ste Foy, Québec, Canada

    Jean Y. Dubé (Professeur titulaire)

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Dubé, J.Y. Les proteines majeures de la secretion prostatique. Androl. 1, 56–58 (1991). https://doi.org/10.1007/BF03034169

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Basic and Clinical Andrology

ISSN: 2051-4190