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Mécanismes régulateurs des α-glucosidases épididymaires chez le rat

Regulatory mechanisms of α-glucosidases in rat epididymis


Epithelial cells of mammalian epididymis produced acid and neutral α-glucosidases (α-G) which are either modulated by hormonal systemic influences or by local factors arising from the rete testis fluid. In this study, ligation of ductuli efferentes in the rat was characterized by a modest elevation of both α-G 15 days after surgery. In adrenalectomized rats, both α-G are lower than in intact animals. Because of the continuance of spermatophagia 2 weeks after ductuli ligation, the observed enzymatic variations cannot be ascribed to paracrine influences; however, the effects of adrenalectomy on α-G levels are obvious and may be attributed to a multifactorial endocrine control (androgens and corticoids).


Les cellules épithéliales de l’épididyme des mammifères contiennent des α-glucosidases (α-G) acide et neutre dont la modulation obéit à un contrôle hormonal systémique ou encore local par le biais du fluide du rete testis. Dans ce travail, la ligature des ductuli efférentes chez ie rat est caractérisée par une élévation modeste des deux α-G 15 jours après la chirurgie. Chez des animaux surrénalectomisés, les activités α-G s’abaissent par référence aux valeurs retrouvées chez l’animal intact. Etant donné la persistance de spermatophagie deux semaines après ligature des ductuli, les variations enzymatiques observées sont difficilement attribuables à des influences paracrines; par contre, les effets de l’absence de corticostérone sur les α-G sont tangibles et reflètent un contrôle stéroïdien multifactoriel (androgènes et corticoïdes).


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Morisset, J., Frenette, G. & Tremblay, R.R. Mécanismes régulateurs des α-glucosidases épididymaires chez le rat. Androl. 1, 53–55 (1991).

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