From: Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis
Basic Information | Results(Mean ± SD) after treatment in two groups | ||
---|---|---|---|
treatment group(with ALA) | control group(with sham therapy) | P Value | |
Raaia et al. [13] 2012 Egypt | 1.Semen parameters after one month sperm concentration(106/ml): 40.4 ± 86.7 total motility(grade a+b+c) (%): 39.2 ± 20.3 progressive motility(grade a+b) (%): 27.6 ± 16.6 2.Semen parameters after two months sperm concentration(106/ml): 43.7 ± 39.7 total motility(grade a+b+c) (%): 45.1 ± 17.9 progressive motility(grade a+b) (%): 33.3 ± 15.8 3.Semen parameters after three months sperm concentration(106/ml): 40.0 ± 27.6 total motility(grade a+b+c) (%): 46.9 ± 19.8 progressive motility(grade a+b) (%): 34.0 ± 17.8 abnormal sperm forms (%): 63.7 ± 13.3 | 1.Semen parameters after one month sperm concentration(106/ml): 26.6 ± 27.4 total motility(grade a+b+c) (%): 40.6 ± 20.1 progressive motility(grade a+b) (%): 29.9 ± 19.9 2.Semen parameters after two months sperm concentration(106/ml): 26.7 ± 22.5 total motility(grade a+b+c) (%): 39.7 ± 16.2 progressive motility(grade a+b) (%): 28.2 ± 14.5 3.Semen parameters after three months sperm concentration(106/ml): 21.8 ± 17.9 total motility(grade a+b+c) (%): 42.8 ± 19.9 progressive motility(grade a+b) (%): 29.8 ± 17.9 abnormal sperm forms (%): 69.3 ± 17.5 | 1.Semen parameters after one month sperm concentration: 0.216 total motility(grade a+b+c): 0.680 progressive motility(grade a+b): 0.789 2.Semen parameters after two months sperm concentration: 0.042* total motility(grade a+b+c): 0.490 progressive motility(grade a+b): 0.415 3.Semen parameters after three months sperm concentration: 0.001* total motility(grade a+b+c): 0.288 progressive motility(grade a+b): 0.303 abnormal sperm forms: 0.128 |
Haghighian et al. [21] 2015 Iran | semen volume(ml): 3.5 ± 0.3 total sperm number(106/ejaculate): 90.4 ± 6.2 sperm concentration(106/ml): 26.3 ± 3.1 progressive motility(grade a+b) (%): 33.4 ± 2.9 fast progressively motility(grade a) (%): 6.5 ± 2.2 slow progressively motility(grade b) (%): 26.9 ± 2.4 non-progressively motility(grade c) (%): 7.1 ± 3.8 immotile spermatozoa(grade d) (%): 59.3 ± 4.5 total motility(grade a+b+c) (%): 40.6 ± 4.9 normal forms(%): 15.3 ± 3.6 vitality(%): 71.4 ± 3.5 | semen volume(ml): 3.5 ± 0.3 total sperm number(106/ejaculate): 77.5 ± 4.5 sperm concentration(106/ml): 22.8 ± 2.7 progressive motility(grade a+b) (%): 27.1 ± 2.3 fast progressively motility(grade a) (%): 2.7 ± 1.3 slow progressively motility(grade b) (%): 24.3 ± 2.2 non-progressively motility(grade c) (%): 8.8 ± 3.2 immotile spermatozoa(grade d) (%): 63.9 ± 2.9 total motility(grade a+b+c) (%): 36.0 ± 3.1 normal forms(%): 13.8 ± 3.7 vitality(%): 72.8 ± 4 | semen volume: 0.991 total sperm number: < 0.001* sperm concentration: < 0.001* progressive motility(grade a+b): < 0.001* fast progressively motility(grade a): < 0.001* slow progressively motility(grade b): 0.011* non-progressively motility(grade c): 0.122 immotile spermatozoa(grade d): 0.005* total motility(grade a+b+c): 0.004* normal forms: 0.153 vitality: 0.255 |
Abbasi et al. [20] 2020 Iran | 1.before microsurgical repair of varicocele/no-medication sperm concentration (106/ml): 52.3 ± 12.5 semen volume (ml): 1.9 ± 0.2 abnormal sperm forms (%): 97.2 ± 0.3 total motility(grade a+b+c) (%): 36.4 ± 5.6 progressive motility(grade a+b) (%): 23.7 ± 3.4 sperm lipid peroxidation(%): 40.7 ± 3.3 spermlipid peroxidation(intensity): 25.2 ± 3.0 DNA fragmentation(%): 11.2 ± 0.6 DNA damage index(%): 23.2 ± 1.5 sperm protamine deficiency(%): 35.3 ± 3.2 2. post-varicocelectomy/post-medication semen parameters sperm concentration (106/ml): 81.6 ± 16.1 semen volume (ml): 3.1 ± 0.4 abnormal sperm forms (%): 93.4 ± 0.7 total motility(grade a+b+c) (%): 50.3 ± 5.2 progressive motility(grade a+b) (%): 35.7 ± 3.9 sperm lipid peroxidation(%): 22.6 ± 1.6 spermlipid peroxidation(intensity): 21.7 ± 1.8 DNA fragmentation(%): 12.2 ± 1.0 DNA damage index(%): 18.3 ± 1.4 sperm protamine deficiency(%): 33.5 ± 3.2 | 1.before microsurgical repair of varicocele/no-medication sperm concentration (106/ml): 47.9 ± 12.1 semen volume (ml): 2.3 ± 0.3 abnormal sperm forms (%): 98.2 ± 0.3 total motility(grade a+b+c) (%): 38.3 ± 5.7 progressive motility(grade a+b) (%): 24.8 ± 4.0 sperm lipid peroxidation(%): 36.2 ± 3.3 spermlipid peroxidation(intensity): 24.1 ± 1.7 DNA fragmentation(%): 13.6 ± 2.4 DNA damage index(%): 20.4 ± 2.3 sperm protamine deficiency(%): 41.7 ± 4.1 2. post-varicocelectomy/post-medication semen parameters sperm concentration (106/ml): 74.4 ± 12.7 semen volume (ml): 3.6 ± 0.3 abnormal sperm forms (%): 95.4 ± 0.7 total motility(grade a+b+c) (%): 39.7 ± 4.4 progressive motility(grade a+b) (%): 26.7 ± 3.8 sperm lipid peroxidation(%): 24.0 ± 1.8 spermlipid peroxidation(intensity): 21.3 ± 1.5 DNA fragmentation(%): 10.3 ± 0.9 DNA damage index(%): 16.4 ± 1.2 sperm protamine deficiency(%): 37.4 ± 3.6 | 1.before microsurgical repair of varicocele sperm concentration: 0.8 semen volume: 0.45 abnormal sperm forms: 0.04* total motility(grade a+b+c): 0.8 progressive motility(grade a+b): 0.83 sperm lipid peroxidation: 0.34 spermlipid peroxidation(intensity): 0.72 DNA fragmentation: 0.39 DNA damage index: 0.32 sperm protamine deficiency: 0.24 2. post-varicocelectomy/post-medication semen parameters sperm concentration: 0.72 semen volume: 0.42 abnormal sperm forms: 0.056 total motility(grade a+b+c): 0.12 progressive motility(grade a+b): 0.11 sperm lipid peroxidation: 0.56 spermlipid peroxidation(intensity): 0.84 DNA fragmentation: 0.2 DNA damage index: 0.32 sperm protamine deficiency: 0.42 |