Table 3 Modeling the evolution of Sertoli cell AR ir (Immunoreactivity), AMH ir and Cx43 ir, onset of a lumen in seminiferous tubules, presence of maturing germ cells, seminiferous cord/tubule diameter and S/T score. This model could determmine ARir, AMH ir and CX ir kinetics during puberty. The age of transition from prepubertal to pubertal was estimated by the point of inflexion of the sigmoid curve modeling the evolution of Sertoli cell AR ir, AMH ir and Cx43 ir
From: Effect of androgens on Sertoli cell maturation in human testis from birth to puberty
Age of the boy with the earliest pubertal value/feature | Age at the inflexion point of the sygmoid curve | Age of the boy with the latest prepubertal value/feature | |
|---|---|---|---|
(Years) | (Years) | (Years) | |
AR ir | 4.6 | 9.88 | 10.8 |
AMH ir | 9.2 | 9.93 | 10.2 |
Cx43 ir | 11.2 | 11.25 | 12.1 |
Lumen | 10.8 | 11.42 | 13.8 |
Maturing Germ Cells | 11.2 | 12 | 12.5 |
Cord/Tub. Diameter | 11.4 | 12.75 | 13.8 |
S/T Score | 12.1 | 13.5 | 13.8 |