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Table 2 Results of histological data for the 7 ages control, Complete Androgen Insentivity Syndrom (CAIS) and Leydig Cell Tumor (LCT) groups

From: Effect of androgens on Sertoli cell maturation in human testis from birth to puberty

Groups Groups 1–7 Group 1 Group 2 Group 3 Group 4 Group 5 Group 6 Group 7 CAIS LCT
Age range 0–16 y. 0–30 d. 1–3 m. 3–6 m. 6 m. - 3 y. 3–6 y. 6–12 y. 12–16 y. 3 m.- 20y. 6-10y.
Mean tubular diameter (μm)
 n 84 12 12 12 12 12 11 13 4 4
 median 75.0 75.0 75.0 80.0 75.0 65.0 65.0 170.0 57.5 137.5
 [min-max] [50–275] [60–80] [70–90] [70–90] [60–90] [55–75] [50–140] [75–275] [55–70] [105–175]
 Kruskal-Wallis/Mann-Whitney p < 0.001 b bc c bc a ab d a d
S/T score
 n 79 12 12 12 9 12 10 12 4 4
 median 1.96 2.77 1.42 1,41 1.46 1,27 2.16 12.07 ** 2.60
 [min-max] [0.4–28.2] [0.88–6.42] [0.68–4.58] [0.4–3.06] [0.88–2.2] [0.86–3.88] [0.66–5.08] [2.84–28.2] [0–2.1]** [2,2–3.34]
 Kruskal-Wallis/Mann-Whitney p < 0.001 ab ab ab a ab ab c ** b
Testicular Fertility Index
 n 79 12 12 12 9 12 10 12 4 4
 median 84.0 85.0 82.0 74.0 76.0 72.0 85.5 100.0 ** 100.0
 [min-max] [34–100] [50–99] [40–100] [34–90] [58–94] [42–100] [42–100] [88–100] [0–95]** [98–100]
 Kruskal-Wallis/Mann-Whitney p < 0.001 a a a a a a b ** b
Most advanced germ cell
 Spermatogonia (n) 73 12 12 12 12 12 10 3 1** 0
 Spermatocyte (n) 2 0 0 0 0 0 0 2 0 0
 Round spermatid (n) 2 0 0 0 0 0 1 1 0 2
 Elongated spermatid (n) 4 0 0 0 0 0 0 4 0 1
 Spermatozoa (n) 3 0 0 0 0 0 0 3 0 1
 Fisher’s exact test p < 0.001          
Lumen
 Absent (n) 71 12 12 12 12 12 9 2 4 0
 Present in only some tubes (n) 4 0 0 0 0 0 2 2 0 3
 Present (n) 9 0 0 0 0 0 0 9 0 1
 Fisher’s exact test p < 0.001          
No Leydig cells
 rare (n) 35 2 0 1 10 12 9 1 0 4 *
 numerous (n) 49 10 12 11 2 0 2 12 4 0 *
 Fisher’s exact test p < 0.001          
  1. The Table gives the histological characteristics of the samples in each group for the following parameters:
  2. - median tubular diameter (cord/tubular diameter)
  3. -S/T score: number of spermatogonia per seminiferous cord/tubule transverse section,
  4. - TFI: Tubular Fertility Index (percentage of the seminiferous cord/tubule cross-section containing at least onegerm cell),
  5. - most advanced germ cell :it were significantly different in group 7 (12-16 y.o.) compared to the other age groups. CAIS samples exhibited a prepubertal pattern with mean tubular diameter lower than in 0-12 y.o. control boys and no lumen within the seminiferous cords.
  6. Groups labeled with the same letters were not significatively different on pairwise comparison. P<0.05 wasconsidered as significant. (Kruskal-Wallis/Mann-Whitney)
  7. n= number in the sample
  8. min-max = minimum-maximum