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Table 1 Parameters analysed in ten patients at baseline and after 1-month treatment

From: d-Chiro-Inositol improves testosterone levels in older hypogonadal men with low-normal testosterone: a pilot study

Patients characteristics

Baseline values

T1 values

p-values

Holm-Bonferroni method

Age (years)

69.30 ± 3.62

   

Height (cm)

175.80 ± 5.51

   

Weight (Kg)

86.04 ± 6.91

84.69 ± 6.56

0.002

0.004

BMI (kg/m2)

27.81 ± 1.32

27.38 ± 1.33

0.001

0.003

Waist Circumference (cm)

115.80 ± 4.64

110.80 ± 4.85

0.003

0.004

HOMA-IR Index

5.41 ± 1.71

3.52 ± 1.02

0.001

0.003

Glycaemia (mg/dL)

103.10 ± 11.14

91.10 ± 6.89

0.001

0.004

Insulin (µIU/L)

21.34 ± 6.27

15.64 ± 4.29

0.004

0.006

Testosterone (ng/dL)

222.80 ± 5.59

262.80 ± 32.11

0.009

0.007

Androstenedione (ng/mL)

0.43 ± 0.12

0.88 ± 0.23

0.002

0.004

Oestradiol (pg/mL)

42.24 ± 4.32

34.15 ± 5.36

0.018

0.007

Oestrone (pg/mL)

128.59 ± 5.60

93.59 ± 13.67

0.001

0.003

T/E2 Ratio

5.31 ± 1.11

7.83 ± 2.04

0.019

0.031

LH (mIU/mL)

12.61 ± 2.67

9.76 ± 1.64

0.005

0.007

Strength Test (Kg)

24.98 ± 1.74

27.10 ± 2.07

0.004

0.005

IIEF Questionnaire

11.50 ± 1.96

13.60 ± 1.96

0.001

0.003

  1. Characteristics of patients involved in the study at baseline and after one-month treatment. Data are shown as mean ± SD. The statistical analysis are performed via Student’s paired T-Test and fixed via Holm-Bonferroni method
  2. T1 after 30 days of treatment; BMI Body-mass Index, HOMA-IR Homeostatic Model Assessment for Insulin Resistance, T/E2 Testosterone/Oestradiol ratio, LH Luteinizing Hormone, IIEF International Index of Erectile Function