Table 3 Comparison of allele and genotype frequencies of the rare variants between patients with OZ or AZ and controls with NZ
Rs | Allele/Genotype | Patients | Controls | P-values | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total (n = 315) | OZ (n = 173) | AZ1 + AZ2 (n = 142) | AZ1 (n = 52) | AZ2 (n = 90) | NZ (n = 995) | [1] | [2] | [3] | [4] | [5] | ||
rs116422109 | T | 625 (99.2) | 343 (99.1) | 282 (99.3) | 102 (98.1) | 180 (100) | 1977 (99.3) | 0.782 | 0.720 | 1.000 | 0.169 | 0.617 |
Ca | 5 (0.8) | 3 (0.9) | 2 (0.7) | 2 (1.9) | 0 (0.0) | 13 (0.7) | ||||||
TT | 310 (98.4) | 170 (98.3) | 140 (98.6) | 50 (96.2) | 90 (100) | 982 (98.7) | 0.781 | 0.719 | 1.000 | 0.168 | 0.616 | |
TC | 5 (1.6) | 3 (1.7) | 2 (1.4) | 2 (3.8) | 0 (0.0) | 13 (1.3) | ||||||
rs202057136 | A | 627 (99.5) | 344 (99.4) | 283 (99.6) | 104 (100) | 179 (99.4) | 1981 (99.5) | 1.000 | 0.672 | 1.000 | 1.000 | 0.580 |
Ga | 3 (0.5) | 2 (0.6) | 1 (0.4) | 0 (0.0) | 1 (0.6) | 9(0.5) | ||||||
AA | 312 (99.0) | 171 (98.8) | 141 (99.3) | 52 (100) | 89 (98.9) | 986 (99.1) | 1.000 | 0.671 | 1.000 | 1.000 | 0.581 | |
AG | 3 (1.0) | 2 (1.2) | 1 (0.7) | 0 (0.0) | 1 (1.1) | 9 (0.9) | ||||||
rs115302634 | A | 627 (99.5) | 345 (99.7) | 282 (99.3) | 103 (99.0) | 179 (99.4) | 1982 (99.6) | 0.732 | 1.000 | 0.361 | 0.368 | 0.542 |
Ga | 3 (0.5) | 1 (0.3) | 2 (0.7) | 1 (1.0) | 1 (0.6) | 8 (0.4) | ||||||
AA | 312 (99.0) | 172 (99.4) | 140 (98.6) | 51 (98.1) | 89 (98.9) | 987 (99.2) | 0.732 | 1.000 | 0.361 | 0.369 | 0.543 | |
AG | 3 (1.0) | 1 (0.6) | 2 (1.4) | 1 (1.9) | 1 (1.1) | 8 (0.8) | ||||||
rs188183810 | C | 628 (99.7) | 345 (99.7) | 283 (99.6) | 104 (100) | 179 (99.4) | 1988 (99.9) | 0.246 | 0.382 | 0.330 | 1.000 | 0.229 |
Ta | 2 (0.3) | 1 (0.3) | 1 (0.4) | 0 (0.0) | 1 (0.6) | 2 (0.1) | ||||||
CC | 313 (99.4) | 172 (99.4) | 141 (99.3) | 52 (100) | 89 (98.9) | 993 (99.8) | 0.246 | 0.382 | 0.330 | 1.000 | 0.229 | |
CT | 2 (0.6) | 1 (0.6) | 1 (0.7) | 0 (0.0) | 1 (1.1) | 2 (0.2) | ||||||