Fig. 3

Circulating AMH serum levels were predictive of negative sperm retrieval outcomes in individuals with Klinefelter syndrome-related spermatogenic failure undergoing testicular sperm extraction (TESE). a Dot plots depict values from the 6 positive sperm retrievals and 13 negative sperm retrievals in Klinefelter syndrome NOA; horizontal bars detail median values and interquartile ranges. Dashed lines represent the cut-off chosen for AMH. ♰ (p=0.01) positive versus negative TESE in individuals with Klinefelter syndrome NOA. Statistical analysis was performed by the two-tailed Mann Whitney U test. b ROC-derived curve showing the AUC, 95% CI (confidence intervals) and P-value. Red dot plots depict optimal AMH cut-off (2.5 pmol/l). Area under the ROC curve (AUC) = 0.84; (95% CI = 0.66 to 1; p= 0.01). For the AMH cut-off: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy: 100%, 76.9%, 66.6%, 100% and 84.2%, respectively (p=0.003). AUC Area Under the Curve,95% CI95% confidence interval,NOA Nonobstructive azoospermia, ROC Receiver operating characteristic, TESE Testicular sperm extrac