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Fig. 5 | Basic and Clinical Andrology

Fig. 5

From: Is ferroptosis involved in ROS-induced testicular lesions in a varicocele rat model?

Fig. 5

Comparison of relative mRNA expression. Legend: Comparison of relative expression of P53, Nrf2 and Slc7a11 mRNA in different groups at 2 (a) and 4 months (b) post induction varicocele. The relative expression of Nrf2 showed a significant increase in the varicocele group compared to the 2 M control group. At 4 months, the relative expression of Slc7a11 was significantly increased in the treated group (V.I-ALA+) compared to the 4 M varicocele group (V.I-ALA). M: month post-surgery or varicocele induction, Nrf2: Nuclear factor erythroid 2–related factor 2, V.I-ALA+: varicocele rats treated with ALA for 2 to 4 months post induction of varicocele, V.I-ALA: varicocele rats treated with water as solvent of ALA for 2 to 4 months post induction of varicocele. Statistical analyses (independent sample T-test) for 2 months, (one way ANOVA) for 4 M samples, for each parameter were carried out between groups and p-value is provided for the groups which showed significant difference

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