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Table 2 Analysis of characteristics of Klinefelter patients with ICPP

From: Idiopathic central precocious puberty in a Klinefelter patient: highlights on gonadotropin levels and pathophysiology

Characteristics during precocious puberty Final puberty-adulthood
Studies Karyotype Age at PP LH LH
post LHRH
T TV Height (cm) LH FSH T TV
Leon et al. [9] Mosaic XY/
XXY/XXXY
8 173
Mühlendahl et al. [10] 47,XXY 8.3 6.3 42 3 3.4 181 3
Mühlendahl et al. [10] 47,XXY 8 1.1 5 189 15 39 0.1 8
Bertelloni et al. [11] 47,XXY 5 4.2 37 2.8 4 176 16 13 2.9 4
Bertelloni et al. [12] 48,XXYY 7 31 130 4 176 45 130 4.2
Fryns et al. [13] 47,XXY
Gonzales-Ellis et al. [14] 47,XXY 8.5 1.9 0.86 164 3.5 2.7 4
Reported case 47,XXY 8 3.5 24 4.35 6 178 19 22 1.16 4
All (Mean ± SD)   7.5 ± 1.3 9 ± 12 58.2 ± 48 2.7 ± 1 4.6 ± 1 177 ± 7 20 ± 17 51 ± 61 2.2 ± 1.4 4.6 ± 1.7
  1. FSH Follicle stimulating hormone, LH Luteinizing hormone, LHRH Luteinizing hormone-releasing hormone, PP Precocious puberty, T Testosterone levels, TV Testicular volume. Testosterone levels (T) are in ng/ml. TV corresponds to testicular volume in ml. LH and FSH are in UI/l.