Table 1 The 100 most cited manuscripts in Andrology

1

Feldman HA. Impotence and its medical and psychosocial correlates - results of the Massachusetts male aging study. Journal of Urology 1994.

2

Rosen RC. The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997.

3

Goldstein I. Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine 1998.

4

Rosen RC. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. International Journal of Impotence Research 1999.

5

Droller MJ. Impotence: NIH consensus development panel on impotence. Journal of the American Medical Association 1993.

6

de Roux N. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proceedings of the National Academy of Sciences of the United States of America 2003.

7

Walsh PC. Impotence following radical prostatectomy - insight into etiology and prevention. Journal of Urology 1982.

8

Lue TF. Drug therapy: Erectile dysfunction. New England Journal of Medicine 2000.

9

Rosen R. Lower urinary tract symptoms and male sexual dysfunction: The multinational survey of the aging male (MSAM-7). European Urology 2003.

10

Evenson DP. Sperm chromatin structure assay: Its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. Journal of Andrology 2002.

11

Eddy EM. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 1996.

12

Johannes CB. Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study. Journal of Urology 2000.

13

Aytac IA. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. British Journal of Urology International 1999.

14

Muscatelli F. Mutations in the dax-1 gene give rise to both x-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature 1994.

15

Wu FCW. Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men. New England Journal of Medicine 2010.

16

Katznelson L. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. Journal of Clinical Endocrinology & Metabolism 1996.

17

Sharma RK. Role of reactive oxygen species in male infertility. Urology 1996.

18

Braun M. Epidemiology of erectile dysfunction: results of the ‘Cologne Male Survey’. International Journal of Impotence Research 2000.

19

Mason AJ. A deletion truncating the gonadotropin-releasing-hormone gene is responsible for hypogonadism in the hpg mouse. Science 1986.

20

Krane RJ. Impotence. New England Journal of Medicine 1989.

21

Thompson IM. Erectile dysfunction and subsequent cardiovascular disease. Journal of the American Medical Association 2005.

22

Tremellen K. Oxidative stress and male infertility-a clinical perspective. Human Reproduction Update 2008.

23

Lue TF. Physiology of erection and pharmacological management of impotence. Journal of Urology 1987.

24

Cattanach BM. Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 1977.

25

de Tejada IS. Impaired neurogenic and endothelium-mediated relaxation of penile smooth-muscle from diabetic men with impotence. New England Journal of Medicine 1989.

26

Esposito K. Effect of lifestyle changes on erectile dysfunction in obese men - A randomized controlled trial. Journal of the American Medical Association 2004.

27

Feldman HA. Erectile dysfunction and coronary risk factors: Prospective results from the Massachusetts Male Aging Study. Preventive Medicine 2000.

28

Boolell M. Sildenafil, a novel effective oral therapy for male erectile dysfunction. British Journal of Urology 1996.

29

Terrett NK. Sildenafil (VIAGRA), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction. Bioorganic & Medicinal Chemistry Letters 1996.

30

Thorner MO. Long-term treatment of galactorrhea and hypogonadism with bromocriptine. British Medical Journal 1974.

31

Hatzimouratidis K. Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation. European Urology 2010.

32

Dubin L. Etiologic factors in 1294 consecutive cases of male infertility. Fertility and Sterility 1971.

33

Rendell MS. Sildenafil for treatment of erectile dysfunction in men with diabetes - A randomized controlled trial. Journal of the American Medical Association 1999.

34

Tut TG. Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. Journal of Clinical Endocrinology & Metabolism 1997.

35

Carter JN. Prolactin-secreting tumors and hypogonadism in 22 men. New England Journal of Medicine 1978.

36

Whorton D. Infertility in male pesticide workers. Lancet 1977.

37

Topaloglu AK. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nature Genetics 2009.

38

Dix DJ. Targeted gene disruption of Hsp70–2 results in failed meiosis, germ cell apoptosis, and male infertility. Proceedings of the National Academy of Sciences of the United States of America 1996.

39

Agarwal A. Role of sperm chromatin abnormalities and DNA damage in male infertility. Human Reproduction Update 2003.

40

Brindley GS. Cavernosal alpha-blockade - a new technique for investigating and treating erectile impotence. British Journal of Psychiatry 1983.

41

Padma-Nathan H. Treatment of men with erectile dysfunction with transurethral alprostadil. New England Journal of Medicine 1997.

42

Morales A. Clinical safety of oral sildenafil citrate (VIAGRA) in the treatment of erectile dysfunction. International Journal of Impotence Research 1998.

43

Virag R. Is impotence an arterial disorder - a study of arterial risk-factors in 440 impotent men. Lancet 1985.

44

Araujo AB. The relationship between depressive symptoms and male erectile dysfunction: Cross-sectional results from the Massachusetts Male Aging Study. Psychosomatic Medicine 1998.

45

Montorsi F. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. European Urology 2003.

46

Mulligan T. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. International Journal of Clinical Practice 2006.

47

Oliva R. Protamines and male infertility. Human Reproduction Update 2006.

48

Brock GB. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: Results of integrated analyses. Journal of Urology 2002.

49

Dhindsa S. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. Journal of Clinical Endocrinology & Metabolism 2004.

50

Roth JC. FSH and LH response to luteinizing hormone-releasing factor in prepubertal and pubertal children, adult males and patients with hypogonadotropic and hypergonadotropic hypogonadism. Journal of Clinical Endocrinology & Metabolism 1972.

51

Zorgniotti AW. Auto-injection of the corpus cavernosum with a vasoactive drug-combination for vasculogenic impotence. Journal of Urology 1985.

52

de Roux N. A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. New England Journal of Medicine 1997.

53

Martin-Morales A. Prevalence and independent risk factors for erectile dysfunction in Spain: Results of the Epidemiologia de la Disfuncion Erectil Masculina study. Journal of Urology 2001.

54

Saleh RA. Oxidative stress and male infertility: From research bench to clinical practice. Journal of Andrology 2002.

55

Derby CA. Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk? Urology 2000.

56

Linet OI. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. New England Journal of Medicine 1996.

57

Agarwal A. Clinical relevance of oxidative stress in male factor infertility: An update. American Journal of Reproductive Immunology 2008.

58

Lue TF. Vasculogenic impotence evaluated by high-resolution ultrasonography and pulsed doppler spectrum analysis. Radiology 1985.

59

Rosen RC. The multinational Men’s Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Current Medical Research and Opinion 2004.

60

Finkelstein JS. Osteoporosis in men with idiopathic hypogonadotropic hypogonadism. Annals of Internal Medicine 1987.

61

Kodama H. Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients. Fertility and Sterility 1997.

62

Lapatto R. Kiss1(−/−) mice exhibit more variable hypogonadism than Gpr54(−/−) mice. Endocrinology 2007.

63

Smith JC. The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer. Journal of Clinical Endocrinology & Metabolism 2001.

64

McCulloch DK. The prevalence of diabetic impotence. Diabetologia 1980.

65

Debraekeleer M. Cytogenetic studies in male-infertility - a review. Human Reproduction 1991.

66

Selvin E. Prevalence and risk factors for erectile dysfunction in the US. American Journal of Medicine 2007.

67

Mulryan K. Reduced vas deferens contraction and male infertility in mice lacking P2X(1) receptors. Nature 2000.

68

Solomon H. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003.

69

Hendren SK. Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Annals of Surgery 2005.

70

Finkelstein JS. Increases in bone-density during treatment of men with idiopathic hypogonadotropic hypogonadism. Journal of Clinical Endocrinology & Metabolism 1989.

71

Chang CS. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proceedings of the National Academy of Sciences of the United States of America 2004.

72

Wang C. Investigation, treatment and monitoring of late-onset hypogonadism in males. European Journal of Endocrinology 2008.

73

Weiss J. Hypogonadism caused by a single amino-acid substitution in the beta subunit of luteinizing-hormone. New England Journal of Medicine 1992.

74

Kaiser DR. Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. Journal of the American College of Cardiology 2004.

75

Ellenber M. Impotence in diabetes - neurologic factor. Annals of Internal Medicine 1971.

76

Althof SE. EDITS: Development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology 1999.

77

Slag MF. Impotence in medical clinic outpatients. Journal of the American Medical Association 1983.

78

Kapoor D. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: Correlations with bioavailable testosterone and visceral adiposity. Diabetes Care 2007.

79

Maden C. History of circumcision, medical conditions, and sexual-activity and risk of penile cancer. Journal of the National Cancer Institute 1993.

80

Palermo GD. Intracytoplasmic sperm injection - a novel treatment for all forms of male factor infertility. Fertility and Sterility 1995.

81

Woolf PD. Transient hypogonadotropic hypogonadism caused by critical illness. Journal of Clinical Endocrinology & Metabolism 1985.

82

Ghofrani HA. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nature Reviews Drug Discovery 2006.

83

Nicolosi A. Epidemiology of erectile dysfunction in four countries: Cross-national study of the prevalence and correlates of erectile dysfunction. Urology 2003.

84

Bivalacqua TJ. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction. Proceedings of the National Academy of Sciences of the United States of America 2004.

85

de Kretser DM. Male infertility. Lancet 1997.

86

Macleod J. The male factor in fertility and infertility .2. Spermatozoon counts in 1000 men of known fertility and in 1000 cases of infertile marriage. Journal of Urology 1951.

87

Sharma RK. The reactive oxygen species - total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Human Reproduction 1999.

88

McVary KT. Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: A randomized, double-blind trial. Journal of Urology 2007.

89

User HM. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. Journal of Urology 2003.

90

Seminara SB. Gonadotropin-releasing hormone deficiency in the human Idiopathic hypogonadotropic hypogonadism and Kallmann’s syndrome: Pathophysiological and genetic considerations. Endocrine Reviews 1998.

91

Korenman SG. Secondary hypogonadism in older men - its relation to impotence. Journal of Clinical Endocrinology & Metabolism 1990.

92

Talcott JA. Patient-reported impotence and incontinence after nerve-sparing radical prostatectomy. Journal of the National Cancer Institute 1997.

93

Montague DK. American Urological Association guideline on the management of priapism. Journal of Urology 2003.

94

Marks LS. Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism - A randomized controlled trial. Journal of the American Medical Association 2006.

95

Benet AE. The epidemiology of erectile dysfunction. Urologic Clinics of North America 1995.

96

Sikka SC. Role of oxidative stress and antioxidants in male infertility. Journal of Andrology 1995.

97

Balhorn R. Aberrant protamine-1 protamine-2 ratios in sperm of infertile human males. Experientia 1988.

98

Daling JR. Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. International Journal of Cancer 2005.

99

Cummins JM. Molecular-biology of human male-infertility - links with aging, mitochondrial genetics, and oxidative stress. Molecular Reproduction and Development 1994.

100

Saleh RA. Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Fertility and Sterility 2003.