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Table 1 Up-regulation of hypoxia pathway genes after 3 and 6 h of LPS-induced inflammation

From: Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis

Gene Name Unigene, GenBank

Fold Change

3 h (n = 7)

6 h (n = 6)

Angiopoietin-like 4 (Angptl4)Rn.119611, NM_199115

20.38 (p = 0.007)

14.12 (p = 0.005)

Basic helix-loop-helix family, member (Bhlhe40)

Rn.81055, NM_053328

No change

3.31

(p = 0.000)

Early growth response 1 (Egr1)

Rn.9096, NM_012551

29.16

(p = 0.006)

6.67

(p = 0.046)

Immediate early response 3 (Ier3)

Rn.23638, NM_212505

9.85

(p = 0.001)

No change

Plasminogen activator inhibitor type 1 (Pai1)

Rn.29367, NM_012620

15.05

(p = 0.023)

No change

Solute carrier family 2 (facilitated glucose transporter), member 1 (Slc2a1, Glut1)

Rn.3205, NM_138827

3.41

(p = 0.002)

No change

  1. Only genes that showed at least a three-fold increase in expression with p < 0.05 were considered statistically significant